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Association between Breslow thickness and dermoscopic findings in acral melanoma
Journal of the American Academy of Dermatology ( IF 13.8 ) Pub Date : 2018-06-13 , DOI: 10.1016/j.jaad.2018.06.004
Je-Ho Mun , Gwanghyun Jo , Claudia C. Darmawan , Jin Park , Jung Min Bae , HyunJu Jin , Woo-Il Kim , Hoon-Soo Kim , Hyun-Chang Ko , Byung-Soo Kim , Moon-Bum Kim

Background

Dermoscopy is a useful tool for the diagnosis of acral melanomas (AMs). However, little is known about the influence of tumor thickness on the dermoscopic findings of AM.

Objective

To investigate the affect Breslow thickness (BT) has on the dermoscopic patterns of AM.

Methods

Data on cases of AM on the glabrous skin were collected from 4 university hospitals. We investigated the frequency of each dermoscopic feature of AM according to the BT. Statistical analysis was performed to investigate the association between the specific dermoscopic patterns and BT.

Results

Multivariable analysis revealed that the colors red (odds ratio [OR] 16.482, 95% confidence interval [CI] 3.605-99.016); blue (OR 7.092; 95% CI 1.707-37.435); and white (OR 5.048, 95% CI 1.152-22.897) were more common in AM with BT >2 mm than those with BT ≤2 mm. Regarding patterns, atypical vascular (OR 34.589, 95% CI 6.458-305.852); blue-white veils (OR 9.605, 95% CI 1.971-72.062); and ulcers (OR 5.084, 95% CI 1.145-24.152) were more frequently detected in cases with BT >2 mm than those with BT ≤2 mm.

Limitations

A retrospective study design and small sample size.

Conclusion

This study showed an association between dermoscopic patterns and tumor thickness among patients with AM. Dermoscopy can be a useful adjuvant tool for predicting BT in AM.



中文翻译:

急性黑素瘤的Breslow厚度与皮肤镜检查结果之间的关联

背景

皮肤镜检查是诊断急性黑色素瘤(AMs)的有用工具。然而,关于肿瘤厚度对AM的皮肤镜检查结果的影响知之甚少。

客观的

要研究Breslow厚度(BT)对AM的皮肤镜模式的影响。

方法

从4所大学医院收集了无毛皮肤AM病例的数据。我们根据BT调查了AM的每个皮肤镜特征的频率。进行统计分析以研究特定皮肤镜模式与BT之间的关联。

结果

多变量分析显示颜色为红色(比值比[OR] 16.482,95%置信区间[CI] 3.605-99.016);蓝色(OR 7.092; 95%CI 1.707-37.435); 在BT> 2 mm的AM中,白色和白色(OR 5.048,95%CI 1.152-22.897)比BT≤2mm的更常见。关于模式,非典型血管(OR 34.589,95%CI 6.458-305.852); 蓝白色面纱(OR 9.605,95%CI 1.971-72.062); BT> 2 mm的患者比BT≤2mm的患者更容易发现溃疡和溃疡(OR 5.084,95%CI 1.145-24.152)。

局限性

回顾性研究设计和小样本量。

结论

这项研究表明,AM患者的皮肤镜检查模式与肿瘤厚度之间存在关联。皮肤镜检查可能是预测AM中BT的有用辅助工具。

更新日期:2018-06-13
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