Angiogenesis is a common pathological characteristic of many solid tumors and vulnerable atherosclerotic plaques. Photothermal therapy (PTT) is a promising method to reduce neovascularization. To increase the targeting ability and efficiency of PTT, a novel polymeric nanosystem that encapsulates phthalocyanine zinc (ZnPc) and perfluorohexane (PFH) was developed to target the new blood vessels of breast tumors. After being conjugated to the anti-VEGFR-2 antibody, the polymeric nanoparticles (NPs) targeted vascular endothelial cells efficiently. The photosensitizer (PS) in the NPs could convert laser energy into heat, generating local high temperatures to kill the surrounding cells under laser irradiation. In addition, the liquid–gas phase transition of PFH was induced, and an enhanced ultrasound (US) and photoacoustic (PA) image could be obtained. US/PA imaging enables visualization of the location of NPs, and laser irradiation position can be guided to the optimal location, resulting in fewer side effects than those from traditional treatments with a high targeting ability and an efficient synergistic effect from the PTT.

中文翻译：

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PA / US双模态成像可使用负载ZnPc / PFH的聚合物纳米颗粒指导VEGFR-2靶向光热疗法†

血管生成是许多实体瘤和脆弱的动脉粥样硬化斑块的常见病理特征。光热疗法（PTT）是减少新血管形成的一种有前途的方法。为了提高PTT的靶向能力和效率，开发了一种新型的封装了酞菁锌（ZnPc）和全氟己烷（PFH）的聚合物纳米系统，以靶向乳腺肿瘤的新血管。与抗VEGFR-2抗体偶联后，聚合物纳米颗粒（NPs）有效地靶向血管内皮细胞。NP中的光敏剂（PS）可以将激光能量转化为热量，从而产生局部高温，从而在激光照射下杀死周围的细胞。另外，引起了PFH的液相-气相转变，并且可以获得增强的超声（US）和光声（PA）图像。