Alzheimer's disease (AD) is a complex, multifactorial neurodegenerative disease that exhibits multiple pathogeneses and heterogeneity. Selenium (Se) is an essential trace element for human and animal nutrition. It has been shown that supplementation with two organic forms of Se, Se-enriched yeast (Se-yeast) and selenomethionine (Se-Met), could improve cognitive impairment, reverse synaptic deficits and mitigate tau pathology in triple-transgenic (3× Tg) AD mice. Se-yeast is well known for its high Se-Met content, which may mediate its anti-AD effects. In addition, a large amount of the physiological and biochemical mechanisms of these two Se drugs in the amelioration AD pathology remains unknown. In this study, the content of Se-yeast aside from Se was analyzed, and the effects of Se-Met and Se-yeast on 3× Tg-AD mice were investigated and compared. The results showed that both Se-Met and Se-yeast not only significantly increased the Se levels, enhanced the antioxidant capacity and improved the cognitive decline in the model, but also decreased the Aβ and tau pathologies in the brain tissue of the AD mice. Moreover, the ability of Se-Met to increase the Se levels in different tissues of the AD mice was more significant than that of Se-yeast. However, the positive effect of Se-yeast on improving the cognitive ability of the AD mice was better than that of Se-Met, likely due to the various elements, vitamins and other nutrients in Se-yeast. Collectively, these results suggest that Se-yeast has potential as a clinical health product or drug for AD but that Se-Met, as a pure organic Se compound, is more suitable for studying the therapeutic mechanism of Se because of its comprehensive effects on AD.

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硒代蛋氨酸和富硒酵母在阿尔茨海默氏病三重转基因小鼠模型中的作用比较

阿尔茨海默氏病（AD）是一种复杂的多因素神经退行性疾病，表现出多种病原性和异质性。硒是人类和动物营养中必不可少的微量元素。研究表明，补充两种有机形式的硒，即富硒酵母（Se-酵母）和硒代蛋氨酸（Se-Met），可以改善三联转基因（3×Tg）的认知障碍，突触逆转并减轻tau病理。 ）AD小鼠。硒酵母以其高的硒蛋氨酸含量而闻名，这可能会介导其抗AD作用。另外，这两种硒药物在改善AD病理学中的大量生理和生化机制仍是未知的。在这项研究中，分析了除硒以外的硒酵母的含量，并比较了Se-Met和Se-酵母对3×Tg-AD小鼠的影响。结果表明，Se-Met和Se-Yeast不仅显着提高了模型中的Se水平，增强了抗氧化能力并改善了认知能力下降，而且还降低了AD小鼠脑组织中的Aβ和tau病理。而且，Se-Met增加AD小鼠不同组织中Se水平的能力比Se-酵母更显着。然而，硒酵母对提高AD小鼠认知能力的积极作用要好于硒蛋氨酸，这可能是由于硒酵母中的多种元素，维生素和其他营养素所致。总的来说，这些结果表明，硒酵母具有作为AD的临床保健产品或药物的潜力，但作为纯有机硒化合物的硒蛋氨酸，