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Green and continuous route to assemble lateral nanodimensional graphitic oxide composites without process interruption
Green Chemistry ( IF 9.8 ) Pub Date : 2018-06-11 , DOI: 10.1039/c8gc01436a
Bijay Kumar Poudel 1, 2, 3, 4 , Kyung-Oh Doh 2, 4, 5, 6 , Jeong Hoon Byeon 1, 2, 3, 4
Affiliation  

A single-pass process was developed to continuously assemble lateral nanoscaled iron (pure iron and iron oxide-hydroxide)-decorated graphitic oxide conjugated with doxorubicin and polyethylene glycol (IDGO@DOX-PEG) flakes. The resulting flakes were employed for magneto- and photo-thermal therapies as well as magnetic resonance (MR) imaging as a theranostic nanosystem. The lateral nanoscaled GO flakes were primarily biocompatible and suitable to suppress burst DOX release because of abundant oxygenated plane and edges for DOX conjugation, and the fully nanoscale system was further feasible for near-infrared induced chemo-phototherapy to kill HeLa cells. The decorated iron nanoparticles exhibited a superparamagnetic behavior. IDGO@DOX-PEG flakes, thus, further demonstrated effective chemo-magnetotherapy under alternating magnetic field as well as contrasting activity for MR imaging. This study offers a new and generalizable concept to continuously assemble composite GO nanoflakes for theranostic nanomedicine which usually requires complicated hazardous chemistries and multiple posttreatments.

中文翻译:

绿色且连续的路线,可在不中断工艺的情况下组装横向纳米级氧化石墨复合材料

开发了一种单程方法,以连续组装与阿霉素和聚乙二醇(IDGO @ DOX-PEG)薄片共轭的横向纳米级铁(纯铁和氢氧化铁)装饰的氧化石墨。所得薄片用于磁热疗法和光热疗法,以及作为磁共振波谱学纳米系统的磁共振(MR)成像。侧面的纳米级GO片主要具有生物相容性,并且由于DOX的结合具有充氧的充氧平面和边缘,因此适合抑制突发DOX释放,并且完全纳米级的系统对于近红外诱导化学光疗杀死HeLa细胞更可行。装饰的铁纳米颗粒表现出超顺磁性行为。因此,IDGO @ DOX-PEG薄片 进一步证明了在交变磁场下有效的化学磁疗以及用于MR成像的对比活性。这项研究提供了一个新的和可推广的概念,以连续组装用于治疗性纳米药物的复合GO纳米薄片,这通常需要复杂的危险化学物质和多次后处理。
更新日期:2018-07-02
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