Photothermal therapy (PTT) is an emerging modality for cancer treatment owing to its localized treatment of tumors and easy combination with other therapeutic approaches. An imaging guided tumor ablation will facilitate the implementation of the treatment to boost efficiency. A type of multifunctional hybrid liposome is synthesized by loading indocyanine green (ICG) into a hybrid liposome based on a mixture of hybrid lipid and 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine–diethylene triamine pentacetate acid–gadopentetate dimeglumine (DMPE-DTPA-Gd). The hybrid liposome exhibited high structure stability and narrow size distribution in aqueous media. According to magnetic resonance imaging (MRI), hybrid liposome after tail vein injection accumulated effectively in subcutaneous CT-26 tumor of mice. Moreover, photothermal therapy is able to ablate tumor effectively under MR imaging guidance. Thus, the MRI visible PTT agent-loaded theranostic nanoplatform is promising for effective cancer treatment.

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多功能杂化脂质体作为磁共振成像引导光热疗法的治疗学平台

由于对肿瘤的局部治疗以及与其他治疗方法的简便结合，光热疗法（PTT）是一种新兴的癌症治疗方法。影像引导的肿瘤消融将促进治疗的实施以提高效率。一种类型的多功能杂化脂质体是通过将吲哚菁绿（ICG）加载到杂化脂质体中而合成的，杂化脂质体是基于杂化脂质和1,2-二肉豆蔻酰基-sn的混合物-甘油-3-磷酸乙醇胺-二亚乙基三胺五乙酸-戊二酸二聚亮氨酸（DMPE-DTPA-Gd）。杂化脂质体在水性介质中显示出高的结构稳定性和窄的尺寸分布。根据磁共振成像（MRI），尾静脉注射后的混合脂质体在小鼠的皮下CT-26肿瘤中有效积聚。此外，光热疗法能够在MR成像指导下有效消融肿瘤。因此，MRI可见的PTT试剂装载的治疗治疗纳米平台有望用于有效的癌症治疗。