当前位置: X-MOL 学术J. Funct. Foods › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Effects of maternal serine supplementation on high-fat diet-induced oxidative stress and epigenetic changes in promoters of glutathione synthesis-related genes in offspring
Journal of Functional Foods ( IF 5.6 ) Pub Date : 2018-06-08 , DOI: 10.1016/j.jff.2018.05.067
Guangtian Cao , Fei Tao , Liu Xin , Zhanming Li , Xihong Zhou

To elucidate the effects of maternal serine supplementation during pregnancy on high-fat (HF) diet-induced oxidative stress in the offspring and the epigenetic mechanisms involved, a control diet, HF diet, or HF diet supplemented with different concentrations of serine dissolved in water was fed to C57BL/6J mouse dams during gestation. Eight male offspring from each dietary group were sacrificed at weaning, Consequently, the serum and hepatic oxidative stress markers and lipid levels in weanlings from dams fed the HF diet supplemented with 1% serine were lower than those of offspring from dams fed the HF diet. Maternal serine supplementation prevented promoter DNA hypermethylation of HF diet-induced glutathione synthesis-related genes, and increased the gene expression and resultant protein contents in the weanlings. Our results therefore suggest that maternal serine supplementation during pregnancy alleviates HF diet-induced oxidative stress by epigenetically regulating glutathione synthesis in the weanling.



中文翻译:

补充母亲丝氨酸对高脂饮食诱导的氧化应激及后代谷胱甘肽合成相关基因启动子表观遗传变化的影响

为了阐明孕妇在怀孕期间补充丝氨酸对高脂(HF)饮食引起的后代氧化应激及其涉及的表观遗传机制的影响,对照饮食,HF饮食或HF饮食中补充了不同浓度的溶解在水中的丝氨酸在妊娠期间将其喂食到C57BL / 6J小鼠水坝。每个断奶日粮中有8个雄性后代被处死,因此,饲喂HF日粮并添加1%丝氨酸的母猪的断奶中的血清和肝脏氧化应激标记物和脂质水平低于饲喂HF日粮的母鼠的后代。孕妇补充丝氨酸可防止HF饮食诱导的谷胱甘肽合成相关基因的启动子DNA甲基化过高,并增加了断奶仔鸡的基因表达和蛋白质含量。

更新日期:2018-06-08
down
wechat
bug