Polymer nanoparticles based on molecular polymer brushes allow precise and independent tailoring of nanoparticle characteristics. This enables the synthesis of soft hydrophilic polymer particles with matching composition and surface chemistry where only the aspect-ratio is varied. PEGylated brush nanoparticles revealed that brush nanorods exhibit higher association and penetration into multicellular tumour spheroids compared to their spherical or filamentous counterparts.

中文翻译：

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分子聚合物刷和多细胞肿瘤球状体的纵横比依赖的相互作用†

基于分子聚合物刷的聚合物纳米颗粒可以精确且独立地定制纳米颗粒的特性。这使得能够合成具有匹配的组成和表面化学的柔软的亲水性聚合物颗粒，其中仅改变了长宽比。聚乙二醇化的刷子纳米颗粒显示，与球形或丝状对应物相比，刷子纳米棒具有更高的缔合性和对多细胞肿瘤球体的渗透性。