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Characterizing the risk related to the exposure to methylmercury over a lifetime: A global approach using population internal exposure Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-15 Thomas Gastellu, Anna Mondou, Marie Bellouard, Jean-Claude Alvarez, Bruno Le Bizec, Gilles Rivière
Seafood products accumulate methylmercury throughout the food chain and are the main source of methylmercury exposure. Methylmercury may trigger a number of adverse health effects, such as neurodevelopmental or nephrotoxic effects, the risk of which cannot be ruled out for the French high consumers of seafood. The characterisation of methylmercury-related risks is generally based on short-term dietary
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Strategy proposal using QSAR models to approach mutagenicity assessment of non intentionally added substances in recycled plastic resins Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-15 Ishan Djelassi, Pauline Lancia, Isabelle Thuillier, José Ginestar, Elena Fioravanzo, Aurélie Baleydier
Transition to the use of recycled plastics raises an issue concerning safety assessment of Non Intentionally Added Substances (NIAS). To assess the mutagenic potential of the recycled polyethylene impurities and to evaluate the need to perform assays on recycled resins, this study lies in identifying existing NIAS associated with recycled Low/High Density Polyethylene and assessing the mutagenicity
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RIFM fragrance ingredient safety assessment, 3-phenyl-3-buten-1-yl acetate, CAS Registry Number 7306-12-9 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-15 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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A 21-day safety evaluation of biotechnologically produced 3-fucosyllactose (3-FL) in neonatal farm piglets to support use in infant formulas Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-15 Jeffrey Pitt, Jennifer Bond, Jason Roper, Paul Tenning, Ratna Mukherjea, Kara Evans, Markku T. Saarinen, Heli Anglenius, Johanna Hirvonen, Oliver Hasselwander, Angela Lim
3-Fucosyllactose (3-FL) is one of the most abundant fucosylated oligosaccharides in human breast milk and is an approved infant formula ingredient world-wide. 3-FL functions as a prebiotic to promote early microbial colonization of the gut, increase pathogen resistance and modulate immune responses. To investigate safety and potential gut microbiota effects, 3-FL was fed for 21-days to farm piglets
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In vitro and in vivo genome-based safety evaluation of Lacticaseibacillus rhamnosus LRa05 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-13 Ting Chen, Yawen Shao, Yinan Zhang, Yunjiao Zhao, Mei Han, Zhonghui Gai
The aim of this study was to comprehensively evaluate the safety of LRa05 (hereinafter “LRa05”) to determine its suitability for use as a probiotic in the food industry. First, we sequenced the genome of LRa05 and then determined whether it contained genes associated with antibiotic resistance, virulence, or pathogenicity. Second, we evaluated the safety of LRa05 in vitro by performing a hemolysis
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Transgenerational toxicity induced by maternal AFB1 exposure in Caenorhabditis elegans associated with underlying epigenetic regulations Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-13 Hongyuan Zhou, Sirui Ren, Yulian Yang, Yuxian Qin, Ting Guo, Ying Zhou, Yuhao Zhang, Liang Ma
Aflatoxin B (AFB), usually seriously contaminates in grain and oil foods or feed, displayed significant acute and chronic toxic effects in human and animal populations. However, little is known about the transgenerational toxic effects induced by a maternal AFB intake at a lower dose on offspring. In our study, only parental wild-type was exposed to AFB (0–8 μg/ml) and the following three filial generations
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Unveiling the mechanisms of trichloroethylene hypersensitivity syndrome: Exploring the role of connexin 43 gap junctions in severe skin damage Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-13 Bo Jiao, Haiqin Jiang, Shuai Liu, Yican Wang, Yuanyuan Chen, Huawei Duan, Yong Niu, Meili Shen, Hongsheng Wang, Yufei Dai
Trichloroethylene (TCE), extensively used as an organic solvent in various industrial applications, has been identified as a causative factor in inducing hypersensitivity syndrome (THS). Currently, there is no specific treatment for THS, and most patients experience serious adverse outcomes due to extensive skin damage leading to severe infection. However, the pathogenesis of THS-associated skin damage
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Sunset Yellow dye effects on gut microbiota, intestinal integrity, and the induction of inflammasomopathy with pyroptotic signaling in male Wistar rats Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-13 Sara Ahmed Zahran, Suzan Mohamed Mansour, Amal Emad Ali, Shady Mansour Kamal, Ute Römling, Hanan Salah El-Abhar, Marwa Ali-Tammam
Although concern persists regarding possible adverse effects of consumption of synthetic azo food dyes, the mechanisms of any such effects remain unclear. We have tested the hypothesis that chronic consumption of the food dye Sunset Yellow (SY) perturbs the composition of the gut microbiota and alters gut integrity. Male rats were administered SY orally for 12 weeks. Analysis of fecal samples before
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Utilization of a novel human hepatocyte-endothelial cell coculture model to determine differential toxicities of pyrrolizidine alkaloid food contaminants Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-13 Joseph W. Zagorski, Norbert E. Kaminski
Pyrrolizidine alkaloids (PA) are comprised of a family of hundreds of metabolites, produced by plants as a mechanism to protect against herbivory. Upon ingestion and metabolism, dehydropyrrolizidine alkaloids are formed, which are known to generate DNA adducts and subsequently double-strand DNA breaks. Within the liver, the most sensitive cell type to PA exposure is the sinusoidal endothelial cell
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RIFM fragrance ingredient safety assessment, spiro[1,3-dioxolane-2,8′(5′H)-[2H-2,4a]methanonaphthalene],hexahydro-1′,1′,5′,5′-tetramethyl-, [2′S-(2′α,4′aα,8′aα)]-, CAS Registry Number 154171-77-4 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-13 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Update to RIFM fragrance ingredient safety assessment, p-tolyl alcohol, CAS Registry Number 589-18-4 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-13 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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RIFM fragrance ingredient safety assessment, 3-(p-isopropylphenyl)propionaldehyde, CAS registry number 7775-00-0 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-13 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Update to RIFM fragrance ingredient safety assessment, 4-methylpentanoic acid, CAS Registry Number 646-07-1 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-12 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Trace elements in commercially available infant formulas in Iran: Determination and estimation of health risks Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-11 Roya Peirovi-Minaee, Mahmoud Taghavi, Marzieh Harimi, Ahmad Zarei
Infants are significantly more vulnerable to trace elements from their foods. The objective of the present study was to ascertain the concentrations of some trace elements namely; arsenic, cadmium, chromium, copper, nickel and lead in infant formulas sold in Iran and to estimate the potential health risks to the infants through consumption of these products. The mean concentrations of As, Cd, Cr, Cu
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Trace metals translocation from soil to plants: Health risk assessment via consumption of vegetables in the urban sprawl of a developing country Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-11 KM Shamsul Haque, Md Saiful Islam, Sujat Ahmed, Md Zillur Rahman, Debolina Halder Hemy, Md Towhidul Islam, Md Kamal Hossain, Md Rafiq Uddin, Abu Reza Md Towfiqul Islam, Md Yousuf Mia, Zulhilmi Ismail, Abdullah Al Bakky, Khalid A. Ibrahim, Abubakr M. Idris
The study was conducted at 15 locations around the thermal power plant of Patuakhali district at the coastal area of Bangladesh to determine trace elements in vegetable and assess risk of toxicity. Eight vegetables, namely, tomato ( L.), radish ( L.), bean ( L.), brinjal ( L.), bottle gourd ( L.), red amaranth ( L.), arum ( L.) and lady's finger ( L.) were analyzed for nine trace metals (Cr, Ni, Cu
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RIFM fragrance ingredient safety assessment, dihydromyrcenol, CAS registry number 18479-58-8 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-11 A.M. Api, D. Belsito, D. Botelho, M. Bruze, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, M. Date, W. Dekant, C. Deodhar, A.D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I. Lee, D.C. Liebler, H. Moustakas, M. Na, T.M. Penning, G. Ritacco, J. Romine, N. Sadekar, T.W. Schultz, D. Selechnik, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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RIFM fragrance ingredient safety assessment, 5-ethyl-2,3,4,5-tetramethylcyclohexen-1-one, CAS Registry Number 17369-60-7 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-11 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Update to RIFM fragrance ingredient safety assessment, ethyl 10-undecenoate, CAS Registry Number 692-86-4 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-11 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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RIFM fragrance ingredient safety assessment, cyclohexanol, 2-methoxy-4-propyl-, CAS Registry Number 23950-98-3 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-11 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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hOGG1: A novel mediator in nitrosamine-induced esophageal tumorigenesis Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-11 De-Rong Tang, Cheng-Lin Li, Zhi-Yun Xu, Zhen-Zhong Zhang, Qian-Wei Wang, Jian-Qiang Zhao
The effect of human 8-Oxoguanine DNA Glycosylase () on exogenous chemicals in esophageal squamous cell carcinoma (ESCC) remain unclear. The study plans to determine expression levels in ESCC and possible interactions with known environmental risk factors in ESCC. We analyzed levels of exposure to urinary nitrosamines in volunteers from high and low prevalence areas by GC-MS. And we performed the interaction
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Occurrence and health risk assessment of tropane alkaloids in cereal foods consumed in Korea Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-11 Songyi Han, Sukyeong Jang, Sujin Oh, Jian Lee, Hwa-Jeong Lee, Yong Eui Koo, Byung Hee Kim
Tropane alkaloids (TA) are natural toxins found in certain plants, including cereals, of which atropine and scopolamine are the main species of concern due to their acute toxicity. This study aimed to determine the occurrence of TA in cereal foods and assess the potential health risks associated with their consumption in Korea. TA levels were analyzed in 80 raw and 71 processed cereal samples, which
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Toxicological safety evaluation of an aqueous lemon balm (Melissa officinalis) extract Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-09 Alexandra R. Lobach, Florian Schmidt, Davide Fedrizzi, Severin Müller
(lemon balm) has a long history of safe use as an aromatic herb, flavoring, tea, food supplement, and traditional medicine. An aqueous extract of the leaves of is intended for use as a food ingredient, however the existing safety database does not contain any high quality toxicological studies to support safe consumer exposure. Therefore, a standard tier 1 genotoxicity battery (bacterial reverse mutation
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RIFM fragrance ingredient safety assessment, 3,3,5-trimethylcyclohexyl ethyl ether, CAS Registry Number 67583-77-1 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-09 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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RIFM fragrance ingredient safety assessment, triethyltrimethyl-2-cyclohexen-1-one, CAS Registry Number 68845-35-2 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-09 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Ginsenoside Rk1 induces autophagy-dependent apoptosis in hepatocellular carcinoma by AMPK/mTOR signaling pathway Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-08 Huanyan Wu, Linlin Qu, Xue Bai, Chenhui Zhu, Yuan Liu, Zhiguang Duan, Hongyan Liu, Rongzhan Fu, Daidi Fan
Hepatocellular carcinoma (HCC) is the third most lethal cancer in the world. Recent studies have shown that suppression of autophagy plays an important role in the development of HCC. Ginsenoside Rk1 is a protopanaxadiol saponin isolated from ginseng and has a significant anti-tumor effect, but its role and mechanism in HCC are still unclear. In this study, a mouse liver cancer model induced by diethylnitrosamine
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Disruption of intestinal epithelial permeability in the Co-culture system of Caco-2/HT29-MTX cells exposed individually or simultaneously to acrylamide and ochratoxin A Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-07 Jiawen Lu, Dan Su, Ying Yang, Mengni Shu, Yuting Wang, Xingtao Zhou, Qiang Yu, Chang Li, Jianhua Xie, Yi Chen
Mycotoxins and thermal processing hazards are common contaminants in various foods and cause severe problems in terms of food safety and health. Combined use of acrylamide (AA) and ochratoxin A (OTA) would result in more significant intestinal toxicity than either toxin alone, but the underlying mechanisms behind this poor outcome remain unclear. Herein, we established the co-culture system of Caco-2/HT29-MTX
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Resistance mechanisms of Saccharomyces cerevisiae against silver nanoparticles with different sizes and coatings Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-07 Yue Yang, Jing Hou, Jian Luan
To investigate the underlying resistance mechanisms of against Ag-NPs with different particle sizes and coatings, transcriptome sequencing (RNA-seq) technology was used to characterize the transcriptomes from exposed to 20-PVP-Ag, 100-PVP-Ag, 20-CIT-Ag and 100-CIT-Ag, respectively. The steroid biosynthesis was found as a general pathway for Ag-NPs stress responding, in which and were inhibited and
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Systemic and immunotoxicity induced by topical application of perfluorohexane sulfonic acid (PFHxS) in a murine model Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-06 Lisa M. Weatherly, Hillary L. Shane, Laurel G. Jackson, Ewa Lukomska, Rachel Baur, Madison P. Cooper, Stacey E. Anderson
Per- and polyfluoroalkyl substances (PFAS) are a large group of stable synthetic surfactants that are incorporated into numerous products for their water and oil resistance and have been associated with adverse health effects. The present study evaluated the systemic and immunotoxicity of sub-chronic 28- or 10-day dermal exposure of PFHxS (0.625–5% or 15.63–125 mg/kg/dose) in a murine model. Elevated
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Silver nanoparticles induced synaptic degeneration via Ca2+/CaMKII signal and Drp1-dependent mitochondrial disorder in HT22 cells Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-06 Xiaoru Chang, Shuyan Niu, Menghao Guo, Mengting Shang, Shunyuan Guo, Xiaozhou Mou, Tianshu Wu, Meng Tang, Yuying Xue
Silver nanoparticles (AgNPs) have been widely used in biomedicine and cosmetics, increasing their potential risks in neurotoxicity. But the involved molecular mechanism remains unclear. This study aims to explore molecular events related to AgNPs-induced neuronal damage by RNA-seq, and elucidate the role of Ca/CaMKII signal and Drp1-dependent mitochondrial disorder in HT22 cells synaptic degeneration
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Mercuric sulfide nanoparticles suppress the neurobehavioral functions of Caenorhabditis elegans through a Skp1-dependent mechanism Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-06 Ludi Li, Yingzi Li, Kewu Zeng, Qi Wang
Cinnabar is the naturally occurring mercuric sulfide (HgS) and concerns about its safety have been grown. However, the molecular mechanism of HgS-related neurotoxicity remains unclear. S-phase kinase-associated protein 1 (Skp1), identified as the target protein of HgS, plays a crucial role in the development of neurological diseases. This study aims to investigate the neurotoxic effects and molecular
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The preventive effect of heat-killed Lactobacillus plantarum on male reproductive toxicity induced by cholestasis in rats Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-06 Hajar Hajian, Mitra Motallebi, Maryam Akhavan Taheri, Nejat Kheiripour, Esmat Aghadavod, Mohammad Esmaeil Shahaboddin
This study investigated the preventive effect of heat-killed () on cholestasis-induced male reproductive toxicity in rats. Rats were divided into control normal, sham control, bile duct ligation (BDL) control, and BDL with heat-killed supplementation groups. The effects on sexual hormones, testicular and epididymal histology, sperm parameters, oxidative stress markers, and inflammatory gene expression
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Update to RIFM fragrance ingredient safety assessment, menthyl acetate (isomer unspecified), CAS registry number 16409-45-3 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-06 A.M. Api, D. Belsito, D. Botelho, M. Bruze, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, A.D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I. Lee, D.C. Liebler, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, J. Romine, N. Sadekar, T.W. Schultz, D. Selechnik, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Broccoli extracellular vesicles enhance the therapeutic effects and restore the chemosensitivity of 5-fluorouracil on colon cancer Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-03 Yaqi Cao, Linhai Hou, Meiqi Li, Jing Zhang, Lei Wang, Changhong Liu, Tianyu Luo, Ling Yan, Lei Zheng
Broccoli contains an amount of biologically active substances, which bring beneficial effects on human health. Plant extracellular vesicles have been shown to be novel key factors in cancer diagnosis and tumor therapy. To date, the challenge of overcoming chemoresistance to 5-fluorouracil (5-FU) to facilitate the clinical management of colorectal cancer (CRC) has not been successful. Nevertheless,
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Mitigation effect of hesperidin on X-ray radiation-induced intestinal barrier dysfunction in Caco-2 cell monolayers Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-03 Ha-Young Park, Jin-Hee Yu
The tight junctions (TJs) and barrier function of the intestinal epithelium are highly sensitive to radiation. However, polyphenols can be used to reverse the effects of radiation. Here, we investigated the effects of hesperidin (hesperetin-7-rhamnoglucoside) on X-ray-induced intestinal barrier dysfunction in human epithelial Caco-2 monolayers. To examine whether hesperidin mitigated the effects of
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Gut microbiota deficiency aggravates arsenic-induced toxicity by affecting bioaccumulation and biotransformation in C57BL/6J mice Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-02 Qianying Liu, Yuenan Liu, Jiazhen Zhang, Youbing Guan, Qihang Zhou, Yan Yan, Weiya Li, Jun An, Meian He
Gut microbiome can influence the arsenic metabolism in mammals. Confusingly, gut microbiome was found to both mitigate and exacerbate arsenic toxicity. In this study, the role of gut microbiota in arsenic bioaccumulation, biotransformation, and organ toxicity in C57BL/6J mice was investigated. Gut microbiota deficiency model was established by antibiotics (Ab) cocktail AVNM. Conventional and gut microbiota
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L-theanine attenuates H2O2-induced inflammation and apoptosis in IPEC-J2 cells via inhibiting p38 MAPK signaling pathway Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-02 Zhongqing Li, Zhiqing Huang, Gang Jia, Hua Zhao, Guangmang Liu, Xiaoling Chen
This study investigated the protective effects of L-theanine on hydrogen peroxide (HO)-induced intestinal barrier dysfunction in IPEC-J2 cells. Results showed that L-theanine reduced HO-induced IPEC-J2 cells inflammation and apoptosis, and decreased protein phosphorylation levels of p38 mitogen-activated protein kinase (p38 MAPK) and nuclear factor kappa-B (NF-κB). The p38 MAPK inhibitor (SB203580)
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Norflurazon causes cell death and inhibits implantation-related genes in porcine trophectoderm and uterine luminal epithelial cells Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-02 Taeyeon Hong, Sunwoo Park, Garam An, Fuller W. Bazer, Gwonhwa Song, Whasun Lim
Norflurazon, an inhibitor of carotenoid synthesis, is a pre-emergent herbicide that prevents growth of weeds. The norflurazon is known to hamper embryo development in non-mammals. However, specific toxic effects of norflurazon on mammalian maternal and fetal cells have not been elucidated. Thus, the hypothesis of this study is that norflurazon may influence the toxic effects between maternal and fetal
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Comparing the effects of developmental exposure to alpha lipoic acid (ALA) and perfluorooctanesulfonic acid (PFOS) in zebrafish (Danio rerio) Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-01 Madeline C. Tompach, Charlotte K. Gridley, Sida Li, John M. Clark, Yeonhwa Park, Alicia R. Timme-Laragy
Alpha lipoic acid (ALA) is a dietary supplement that has been used to treat a wide range of diseases including obesity and diabetes and have lipid-lowering effects, making it a potential candidate for mitigating dyslipidemia resulting from exposures to the per- and polyfluoroalkyl substance (PFAS) family member perfluorooctanesulfonic acid (PFOS). ALA can be considered a non-fluorinated structural
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Effects of rutin against deltamethrin-induced testicular toxicity in rats: Biochemical, molecular, and pathological studies Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-01 Sefa Küçükler, Orhan Çelik, Selçuk Özdemir, Şeyma Aydın, Selim Çomaklı, Elif Dalkılınç
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Evaluation of biotoxins and toxic metal risks in mussels from the Sea of Marmara following marine mucilage Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-01 Hande Doğruyol, Şafak Ulusoy, Nuray Erkan, Sühendan Mol, Özkan Özden, İdil Can Tunçelli, Şehnaz Yasemin Tosun, Didem Üçok, Eda Dağsuyu, Refiye Yanardağ
The mucilage phenomenon observed in the Sea of Marmara in 2021, has raised public concern about seafood safety. Mediterranean mussels serve as a vehicle in food chain, enabling the transfer of pollutants. Farmed and wild mussels were collected from 4 different stations throughout the fishing season. Biotoxins causing amnesic, paralytic, or diarrhetic shellfish poisonings (ASP, PSP, or DSP) were examined
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The role of JAK2/STAT3 pathway in non-cytotoxic concentrations of DON-induced aggravation of inflammatory response in IL-10 deficient RAW264.7 cells Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-01 Junya Zeng, Ziman Lin, Jiangyu Tang, Xingxiang Chen, Kehe Huang, Fang Gan
Deoxynivalenol (DON) as a mycotoxin was commonly found in food and cereals which can affect immune function and inflammatory response. The majority of foods contain DON at levels below the official limit. This study aimed to evaluate the effects of non-cytotoxic concentration of DON on inflammation and its mechanisms using the IL-10 gene-silenced RAW264.7 cell model. The results showed that a non-cytotoxic
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Study of cytotoxicity in neuroblastoma cell line exposed to patulin and citrinin Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-03-01 Cassandra T. Mitchell, Luna Bridgeman, Claudia Moyano-López, Raquel Penalva-Olcina, Cristina Juan, Ana Juan-García
Mycotoxins can be found in food and feed storage as well as in several kinds of foodstuff and are capable of harming mammals and some of them even in small doses. This study investigated on the undifferentiated neuronal cell line SH-SY5Y the effects of two mycotoxins: patulin (PAT) and citrinin (CTN), which are predominantly produced by fungi species and . Here, the individual and combined cytotoxicity
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RIFM fragrance ingredient safety assessment, methyl vanillate, CAS Registry Number 3943-74-6 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-28 A.M. Api, D. Belsito, D. Botelho, M. Bruze, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, A.D. Fryer, L. Jones, K. Joshi, M. Kumar, A. Lapczynski, M. Lavelle, I. Lee, D.C. Liebler, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, J. Romine, N. Sadekar, T.W. Schultz, D. Selechnik, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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RIFM fragrance ingredient safety assessment, germacrene D, CAS Registry Number 23986-74-5 Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-28 A.M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Freidrich, G.A. Burton Jr., M.A. Cancellieri, H. Chon, M.L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A.D. Fryer, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T.M. Penning, G. Ritacco, N. Sadekar, I. Schember, T.W. Schultz, F. Siddiqi, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura
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Pathologists’ perspective on the study design, analysis, and interpretation of proliferative lesions in a lifetime rodent carcinogenicity bioassay of sucralose Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-28 Susan A. Elmore, Jerold E. Rehg, Trenton R. Schoeb, Jeffrey I. Everitt, Brad Bolon
Sucralose, a sugar substitute first approved for use in 1991, is a non-caloric sweetener regulated globally as a food additive. Based on numerous experimental animal studies (dating to the 1980s) and human epidemiology studies, international health agencies have determined that sucralose is safe when consumed as intended. A single lifetime rodent carcinogenicity bioassay conducted by the Ramazzini
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LCP1-mediated cytoskeleton alterations involve in arsenite-triggered malignant phenotype of human immortalized prostate stromal cells Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-28 Yiping Yang, Menghan Zhou, Yurun Huang, Xiaotong Ye, Yingxi Mo, Yi Huang, Shan Wang
The connection between continuous arsenic exposure and prostate cancer is already established. However, the exact mechanisms of arsenic tumorigenesis are far from clear. Here, we employed human prostate stromal immortalized cells (WPMY-1) continuous exposure to 1 and 2 μM arsenite for 29 weeks to identify the malignant phenotype and explore the underlying molecular mechanism. As expected, continuous
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Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-27 Suramya Waidyanatha, Bradley J. Collins, Tim Cristy, Michelle Embry, Stefan Gafner, Holly Johnson, Josh Kellogg, Julie Krzykwa, Siheng Li, Constance A. Mitchell, Esra Mutlu, Sarah Pickett, Hong You, Richard Van Breemen, Timothy R. Baker
Increases in botanical use, encompassing herbal medicines and dietary supplements, have underlined a critical need for an advancement in safety assessment methodologies. However, botanicals present unique challenges for safety assessment due to their complex and variable composition arising from diverse growing conditions, processing methods, and plant varieties. Historically, botanicals have been
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Antimicrobial cetylpyridinium chloride causes functional inhibition of mitochondria as potently as canonical mitotoxicants, nanostructural disruption of mitochondria, and mitochondrial Ca2+ efflux in living rodent and primary human cells Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-24 Sasha R. Weller, John E. Burnell, Brandon M. Aho, Bright Obeng, Emily L. Ledue, Juyoung K. Shim, Samuel T. Hess, Julie A. Gosse
People are exposed to high concentrations of antibacterial agent cetylpyridinium chloride (CPC) via food and personal care products, despite little published information regarding CPC effects on eukaryotes. Here, we show that low-micromolar CPC exposure, which does not cause cell death, inhibits mitochondrial ATP production in primary human keratinocytes, mouse NIH-3T3 fibroblasts, and rat RBL-2H3
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Indole-3-carboxaldehyde alleviates cisplatin-induced acute kidney injury in mice by improving mitochondrial dysfunction via PKA activation Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-24 Peipei Yuan, Aozi Feng, Yaxin Wei, Saifei Li, Yang Fu, Xiao Wang, Menghuan Guo, Weisheng Feng, Xiaoke Zheng
Cisplatin (DDP) is widely used in the treatment of cancer as a chemotherapeutic drug. However, its severe nephrotoxicity limits the extensive application of cisplatin, which is characterized by injury and apoptosis of renal tubular epithelial cells. This study aimed to reveal the protective effect and its underlying mechanism of Indole-3-carboxaldehyde (IC) against DDP-induced AKI in mice and NRK-52E
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3-Monochloropropane-1,2-diol esters induce HepG2 cells necroptosis via CTSB/TFAM/ROS pathway Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-24 Shuang Guan, Xiao Qu, Jianfeng Wang, Duoduo Zhang, Jing Lu
3-monochloropropane-1,2-diol esters (3-MCPDE) are toxic substances that form in food thermal processing and have a diverse range of toxicities. In this study, we found that 3-MCPDE triggered necroptosis by RIPK1/RIPK3/MLKL pathway in HepG2 cells. Previous studies have shown that ROS is an important activator of RIPK1 and RIPK3. The data showed that 3-MCPDE induced excessive ROS production through mitochondrial
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Complementary transcriptomic and proteomic analyses elucidate the toxicological molecular mechanisms of deoxynivalenol-induced contractile dysfunction in enteric smooth muscle cells Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-23 Yu Qiao, Xu Ji, Huiduo Guo, Weijiang Zheng, Wen Yao
Deoxynivalenol (DON) is one of the frequent Fusarium mycotoxins and poses a serious threat to public health worldwide. DON-induced weight loss is tightly connected with its ability to decrease feed intake by influencing gastrointestinal tract (GIT) motility. Our previous reports indicated that DON interfered with intestinal motility by injuring the contractility of enteric smooth muscle cells (SMC)
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Isoliquiritin counteracts cadmium-induced intestinal damage in mice through enhancing intestinal barrier function and inhibiting apoptosis Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-23 Linxian Zhao, Haina Zhang, Peng Jiang, Guangmeng Xu
Cadmium (Cd), a crucial toxic environmental pollutant, can induce damage to many organs, especially the gastrointestinal tract. Isoliquiritin (ISO), a critical flavonoid glycoside compound isolated from , has anti-inflammatory, anticancer, antioxidant and other pharmaceutical value. However, the potential roles of ISO in Cd-induced intestinal damage have not been reported yet. This study aimed to research
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Toll-like receptor stimulants in processed meats promote lipid accumulation in macrophages and atherosclerosis in Apoe−/− mice Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-21 Tola A. Faraj, Giovanna Edroos, Clett Erridge
Dietary intake of processed meat is a risk factor for cardiovascular disease. However, the effects of processed meats on lipid metabolism in macrophages, a key regulator of cardiovascular risk, have remained largely unexplored.
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Cumulative risk assessment of dietary exposure of the adult population in Serbia to pesticides that have chronic effects on the thyroid gland through fresh fruits and vegetables Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-21 Bozidar Udovicki, Nikola Tomic, Dragica Brkic, Ana Sredojevic, Milica Kaludjerovic, Bojana Spirovic Trifunovic, Nada Smigic, Ilija Djekic
In contrast to the traditional approach to risk assessment, which focuses on a single chemical, cumulative exposure and risk assessment considers the consequences of exposure to multiple chemical combinations. A cumulative risk assessment of dietary exposure of adult females and adult males to pesticides with chronic effects on the thyroid was conducted by estimation of the Total Margin of Exposure
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Benzophenone-3 alters expression of genes encoding vascularization and epithelial-mesenchymal transition functions during Trp53-null mammary tumorigenesis Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-20 Elena Morozova, Anastasia Kariagina, Calista Busch, Richard C. Schwartz
Benzophenone-3 (also referred to as oxybenzone) is a putative endocrine disrupting chemical and common ingredient in sunscreens and other personal care products. We previously showed that benzophenone-3 was promotional for epithelial tumorigenesis in mice fed adult high-fat diet, while protective against the incidence of more aggressive spindle cell tumors in the same treatment group. In this study
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Arsenic disturbs neural tube closure involving AMPK/PKB-mTORC1-mediated autophagy in mice Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-20 Xiujuan Li, Gexuan Li, Shuo Cui, Yue Hou, Zelin Li, Ziyi Yan, Tingjuan Huang, Taoran Zhao, Hongkai Su, Bingrui Zhou, Juan Zhang, Ruifang Ao, Hong Zhao, Yulan Qiu, Zhizhen Liu, Jun Xie
Arsenic exposure is a significant risk factor for folate-resistant neural tube defects (NTDs), but the potential mechanism is unclear. In this study, a mouse model of arsenic-induced NTDs was established to investigate how arsenic affects early neurogenesis leading to malformations. The results showed that exposure to arsenic caused a decline in the normal embryos, an elevated embryo resorption, and
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Toxicological evaluation of a fish oil concentrate containing Very Long Chain Fatty Acids Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-20 Derek Tobin, Harald Svensen, Devanand Shanmugasundaram, Bente Ruyter, Iren Stoknes, Michael Dornish
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Caspase-8 dependent apoptosis contributes to dyskinesia caused by muscle defects and neurotoxicity in zebrafish exposed to zearalenone Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-19 Yunpeng Wang, Shuaiting Li, Zhi Cheng, Ziyuan Zhang, Yu Xu, Huan Zhang, Ting Xu, Jianqiang Chen, Danyang Yin, Wenhua Yan, Huizhe Huang
Zearalenone (ZEA), one of the usual mycotoxins, has been recognized in many areas and crops, posing a significant threat to the living organisms even to human beings. However, the mechanisms of locomotive defects remain unknown. Herein, zebrafish larvae was employed to investigate ZEA effects on developmental indexes, muscle and neural toxicity, apoptosis, transcriptome and motor behaviors of zebrafish
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Differential effect of the duration of exposure on the carcinogenicity of cadmium in MCF10A mammary epithelial cells Food Chem. Toxicol. (IF 4.3) Pub Date : 2024-02-19 Alina-Andreea Zimta, Diana Cenariu, Adrian Bogdan Tigu, Cristian Moldovan, Ancuta Jurj, Radu Pirlog, Cristian Pop, Eugen S. Gurzau, Eva Fischer-Fodor, Laura Pop, Cornelia Braicu, Ioana Berindan-Neagoe
The carcinogenic role of cadmium (Cd) in breast cancer is still debatable. Current data points to duration of exposure as the most important element. In our study, we designed an model to investigate the effects of 3 weeks versus 6 weeks of low-level CdCl exposure on MCF10A cells. Our results demonstrated that after 3 weeks of CdCl exposure the cells displayed significant changes in the DNA integrity