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  • Probiotic attributes and prevention of LPS-induced pro-inflammatory stress in RAW264.7 macrophages and human intestinal epithelial cell line (Caco2) by newly isolated Weissella cibaria strains
    Food Funct. (IF 3.247) Pub Date : 2018-01-18
    Shashank Singh, Ruchika Bhatia, Ankit Singh, Paramdeep Singh, Ramandeep Kaur, Pragyanshu Khare, Ravi Kiran Purama, Ravneet Kaur Boparai, Praveen Rishi, Padma Ambalam, Sanjay Bhadada, Mahendra Bishnoi, Jaspreet Kaur, Kanthi Kiran Kondepudi

    Probiotic bacteria belonging to lactic acid bacteria are known to modulate gut associated immune responses. Not many studies are reported on the role of Weissella species in preventing lipopolysaccharide (LPS) induced proinflammatory stress in murine macrophages. Therefore, the present study was taken up to evaluate probiotic attributes of four newly isolated Weissella strains (two each from fermented dosa batter and human infant faecal sample), cholesterol reduction, adhesion to Caco2 cells and mucin and their ability to prevent LPS-induced nitric oxide and proinflammatory cytokine (IL-6, IL-1β and TNFα) production by the murine macrophages and IL-8 production by the human epithelial cells. Reduction in LPS induced pro-inflammatory stress was compared with a well studied probiotic bacterium, Lactobacillus rhamnosus GG.Results suggested that the strains were tolerant to gastric conditions (pH 3.0) and bile salts, showed moderate cell surface hydrophobicity, cholesterol reduction and adhesion to Caco2 cells and gastric mucin. All the strains could prevent LPS-induced nitric oxide and IL-6 production in murine macrophages whereas strain 28 alone prevented IL-1β production. All the strains could prevent IL-8 production by the human epithelial cells. Present study lead to the first line selection of W. cibaria 28 as a putative strain for future studies as it showed adhesion to Caco2 cells and gastric mucin and cholesterol reduction besides preventing LPS-induced pro-inflammatory stress in macrophages and in human colonic epithelial cells.

    更新日期:2018-01-18
  • Assessing the consumption of berries and associated factors in the United States using the National Health and Nutrition Examination Survey (NHANES), 2007–2012
    Food Funct. (IF 3.247) Pub Date : 2017-12-29
    Britt M. Burton-Freeman, Patricia M. Guenther, Miyoung Oh, David Stuart, Helen H. Jensen
    更新日期:2018-01-18
  • Ambient storage of microencapsulated Lactobacillus plantarum ST-III by complex coacervation of type-A gelatin and gum arabic
    Food Funct. (IF 3.247) Pub Date : 2017-12-26
    Meng Zhao, Ying Wang, Xue Huang, Michael Gaenzle, Zhengjun Wu, Katsuyoshi Nishinari, Nan Yang, Yapeng Fang
    更新日期:2018-01-18
  • An exploratory study of red raspberry (Rubus idaeus L.) (poly)phenols/metabolites in human biological samples
    Food Funct. (IF 3.247) Pub Date : 2017-12-21
    Xuhuiqun Zhang, Amandeep Sandhu, Indika Edirisinghe, Britt Burton-Freeman
    更新日期:2018-01-18
  • Dietary pectin and mango pulp effects on small intestinal enzyme activity levels and macronutrient digestion in grower pigs
    Food Funct. (IF 3.247) Pub Date : 2018-01-05
    Anton M. Pluschke, Barbara A. Williams, Dagong Zhang, Michael J. Gidley
    更新日期:2018-01-17
  • Zein-derived peptides as nanocarriers to increase the water solubility and stability of lutein
    Food Funct. (IF 3.247) Pub Date : 2018-01-16
    Yan Jiao, Xiqun Zheng, Ying Chang, Dajing Li, Xiaohong Sun, Xiaolan Liu
    更新日期:2018-01-16
  • The Seventh Biennial Berry Health Benefits Symposium
    Food Funct. (IF 3.247) Pub Date : 2018-01-16
    Navindra P. Seeram, Britt Burton-Freeman
    更新日期:2018-01-16
  • Coffee consumption promotes skeletal muscle hypertrophy and myoblast differentiation
    Food Funct. (IF 3.247) Pub Date : 2018-01-15
    Young Jin Jang, Hyo Jeong Son, Ji-sun Kim, Chang Hwa Jung, Jiyun Ahn , Jinyoung Hur, Taeyoul Ha

    Coffee is a widely consumed beverage worldwide and is believed to help prevent the occurrence of various chronic diseases. However, the effect of coffee on skeletal muscle hypertrophy, differentiation and the mechanisms of action responsible have remained unclear. To investigate the effect of coffee on skeletal muscle hypertrophy, mice were fed a normal diet or a normal diet supplemented with 0.3% coffee or 1% coffee. Coffee supplementation was observed to increase skeletal muscle hypertrophy, while simultaneously upregulating protein expression of total MHC, MHC2A, and MHC2B in quadricep muscle. Myostatin expression was also attenuated, and IGF1 was upregulated with subsequent phosphorylation of Akt and mTOR, while AMPK phosphorylation was attenuated. Coffee also increased the grip strength and PGC-1α protein expression, and decreased the expressions of TGF-β and myostatin in tricep muscle. Coffee activated the MKK3/6-p38 pathway and upregulated PGC-1α, which may play a role in promoting myogenic differentiation and myogenin expression in C2C12 cells. These results suggest that coffee increases skeletal muscle function and hypertrophy by regulating the TGF-β/myostatin-Akt-mTORC1.

    更新日期:2018-01-15
  • The Effects Of Whey And Soy Proteins On Growth Performance, Gastrointestinal Digestion, And Selected Physiological Responses In Rats
    Food Funct. (IF 3.247) Pub Date : 2018-01-15
    Barbara Wroblewska, Jerzy Juskiewicz, Bartosz Kroplewski, Adam Jurgonski, Ewa Wasilewska, Dagmara Złotkowska, Lidia Hanna Markiewicz

    The objective of this work was to identify the nutritional and physiological effects of commercial soy and whey protein preparations. Wistar rats were fed with soy (S), whey (W), or casein (C) preparations as the sole dietary protein source. Nitrogen balance, body composition, changes in caecal microbiota, mucosal and bacterial enzyme activity, and allergenic potential of the preparations were analysed. The whey diet elicited greater skeletal muscle anabolism than the soy diet. Rats from the S group had the lowest values of body weight, fat, and lean mass gain. Compared to casein, soy and whey preparations decreased the protein efficiency ratio, increased N in the urine, and triggered reduction of ammonia levels in the caecum. Changes in β-glucuronidase and β-galactosidase activity in the small intestine, caecum, and colon, between experimental groups were observed. Significant differences were noted in the total counts of anaerobic bacteria and sulphite reducing bacteria during soy and whey treatment. This probably affected short chain fatty acids level in caecal digesta resulting in the lowest propionic acid and total putrefactive short chain fatty acids levels during S treatment. Generally, whey preparations are a good choice for rapid bodybuilding (skeletal muscles), whereas soy preparations are more helpful during mass reduction.

    更新日期:2018-01-15
  • Formation of shelf stable Pickering high internal phase emulsions (HIPE) through the inclusion of whey protein microgels
    Food Funct. (IF 3.247) Pub Date : 2017-12-22
    Somayeh Zamani, Nicholas Malchione, Michael J. Selig, Alireza Abbaspourrad
    更新日期:2018-01-15
  • Association of fatty acids and lipids metabolism in placenta with early spontaneous pregnancy loss in Chinese
    Food Funct. (IF 3.247) Pub Date : 2018-01-12
    Kelei Li, Xiaotian Zhang, Gong Chen, Lijun Pei, Hailong Xiao, Jiajing Jiang, Jiaomei Li, X. Zheng, Duo Li

    The aim of the present study was to evaluate the association of fatty acids and lipids metabolism in placenta with early spontaneous pregnancy loss (ESPL) in Chinese. Seventy women with ESPL and 29 healthy pregnant women who asked for legal induced abortion were included in case and control groups, respectively. Gestational age of subjects in both case and control groups ranged from 4 to 10 weeks. Total fatty acids composition in decidual and villous tissues was detected by gas-liquid chromatography using standard method. Metabonomics analysis of decidual and villous tissues was conducted by ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-QTOFMS). Total C18:3n-3 in decidual and villous tissues, total n-3 polyunsaturated fatty acid (n-3 PUFA) in decidual tissue, and total C18:2n-6 in villous tissue were all significantly lower in cases than in controls. The ratio of C20:4n-6/C20:5n-3 in villous tissue was significantly higher, but prostaglandin I2 as well as hydroxyeicosapentaenoic acid, leukotriene B5 and thromboxane B3 in villous tissue were significantly lower in cases than in controls. In addition, the low content of lysophosphatide in decidual and villous tissues and the low content of diacylglycerol in villous tissue were also associated with the occurance of ESPL. In conclusion, lack of essential fatty acids, high ratio of C20:4n-6/C20:5n-3, abnormal eicosanoids metabolism and low content of lysophosphatide and diacylglycerol in placenta were potential risk factors for ESPL in Chinese.

    更新日期:2018-01-12
  • Anti-alzheimers activity and molecular mechanism of albumin-derived peptides against AChE and BChE
    Food Funct. (IF 3.247) Pub Date : 2018-01-12
    zhipeng Yu, sijia wu, wenzhu zhao, long ding, yue FAN, david shiuan , Jingbo Liu, Feng Chen

    Alzheimer’s disease (AD) is a global health issue affecting millions of elderly people worldwide. The aim of the present study was to identify novel anti-AD peptides isolated from the albumin. Anti-AD activities of the peptides were evaluated via inhibitory activities on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Furthermore, the potential molecular mechanisms of the KLPGF / AChE were investigated by CDOCKER of Discovery studio 2017. Results revealed that peptide KLPGF could effectively inhibit AChE with an inhibition rate of 61.23% at a concentration of 50 μg/mL. And the peptide KLPGF contacted with acylation sites and peripheral anion sites of AChE. The present study demonstrated that the peptide KLPGF could become potential functional food intervention in AD.

    更新日期:2018-01-12
  • Protective effect of rosmarinic acid and carnosic acid against streptozotocin-induced oxidation, glycation, inflammation and microbiota imbalance in diabetic rats
    Food Funct. (IF 3.247) Pub Date : 2018-01-12
    Juanying Ou, Junqing Huang, Danyue Zhao, Bin Du, Mingfu Wang

    This study evaluated the protective effects of two rosemary components, namely, rosmarinic acid and carnosic acid against hypoglycemia, hyperlipidemia, oxidative stress and an imbalanced architecture of gut microbiota in diabetic rats. The treatment with rosmarinic acid and carnosic acid (30 mg/Kg) decreased the levels of fasting plasma glucose (23.7%, 15.6%), total cholesterol (30.4%, 14.1%), and triglyceride (65.7%, 47.8%) at 15 weeks. Rosmarinic acid and carnosic acid also exhibited antioxidative and anti-glycative effect by lowering the formation of MDA and advanced glycation end-products. In addition, they showed protective effects against tissue damage and inflammation in the abdominal aorta based on microscopic observation and the analysis of protein expression. Finally, their prebiotic effects on gut microbiota were demonstrated by increasing the population of diabetes-resistant bacteria and decreasing the amount of diabetes-sensitive bacteria. Overall, rosmarinic acid showed stronger protective effect than carnosic acid in mitigating the diabetic symptoms in rats.

    更新日期:2018-01-12
  • In vitro digestion with bile acids enhances the bioaccessibility of kale polyphenols
    Food Funct. (IF 3.247) Pub Date : 2018-01-12
    Isabelle Yang, Guddadarangavvanahal Jayaprakasha, Bhimanagouda S. Patil

    Kale (Brassica oleracea) is a leafy green vegetable belonging to the Brassicaceae family, and kale leaves have large amounts of dietary fiber and polyphenolics. Dietary fiber can bind bile acids, thus potentially improving cholesterol levels; however, whether the polyphenols from kale contribute to in vitro bile acid binding capacity remains unclear. In the present study, kale was extracted with hexane, acetone, and MeOH:water and the extracts, as well as the fiber-rich residue, were tested for their bile acid binding capacity. The fiber-rich residue bound total bile acids in amounts equivalent to that bound by raw kale. The lyophilized acetone extract bound significantly more glycochenodeoxycholate and glycodeoxycholate and less of other bile acids. To test whether bile acid binding enhanced the bioaccessibility of polyphenolic compounds from kale, we used ultra-performance liquid chromatography coupled with electrospray ionization/quadrupole-time-of-flight mass spectrometry to identify kale polyphenolics and measure their bioaccessibility in an in vitro digestion reaction. This identified 36 phenolic compounds in kale, including 18 kaempferol derivatives, 13 quercetin derivatives, 4 sinapoyl derivatives, and one caffeoylquinic acid. The bioaccessibility of these phenolics was significantly higher (69.4%) in digestions with bile acids. Moreover, bile acids enhanced the bioaccessibility of quercetin by 25 times: only 2.7% of quercetin derivatives were bioaccessible in the digestion without bile acids, but with bile acids, their accessibility increased to 69.5%. Bile acids increased the bioaccessibility of kaempferol from 37.7% to 69.2%. The extractability and biostability of total phenolics in the digested residue increased 1.8 fold in the digestions with bile acids. These results demonstrated the potential use of kale to improve human health.

    更新日期:2018-01-12
  • Edible oleogels: an opportunity for fat replacement in foods
    Food Funct. (IF 3.247) Pub Date : 2018-01-12
    Artur J. Martins, A. A. Vicente, Rosiane L. Cunha, Miguel A. Cerqueira

    The scientific and industrial communities have been giving great attention to the development of new bio-based materials with potential use in innovative technological applications. Among these materials are the structures with gel-like behavior that can be used in cosmetic, pharmaceutical and food industries, aiming at controlling the physical properties of final products. In the past ten years, words like oleogel and organogel have been increasingly used, being the existent number of manuscripts and patents a proof of this tendency. In the food industry, oleogels can be used to control phase separation, decrease mobility and migration of the oil phase, providing solid-like properties without using high levels of saturated fatty acids as well as to be a carrier of bioactive compounds. In most cases, their main features are related to the reorganization process of gelators after an increase of the temperature, above the melting or glass transition temperature of the materials, known as the direct method, but it is also possible to develop oleogels by indirect methods, such as emulsification and solvent exchange technique. In the direct methods, the reorganization is able to physically entrap oil leading to different physicochemical properties, being the rheological behavior and texture properties the frequently most studied ones. This review overviews the use of food grade and bio-based structurants to produce edible oleogels, aiming at fat replacement and structure-tailoring. Gelation mechanisms and oil phases used during oleogel production are discussed, as well as the current food applications and future trends for this kind of structures.

    更新日期:2018-01-12
  • Isoenergic modification of whey protein structure by denaturation and crosslinking using transglutaminase
    Food Funct. (IF 3.247) Pub Date : 2018-01-05
    Emil G. P. Stender, Glykeria Koutina, Kristoffer Almdal, Tue Hassenkam, Alan Mackie, Richard Ipsen, Birte Svensson
    更新日期:2018-01-12
  • Anti-fibrotic activity of polyphenol-enriched sugarcane extract in rats via inhibition of p38 and JNK phosphorylation
    Food Funct. (IF 3.247) Pub Date : 2017-12-21
    Liwen Wang, Min-Hsiung Pan, Chih-Yu Lo, Hui Zhao, Shiming Li, Chi-Tang Ho, Guliang Yang
    更新日期:2018-01-11
  • 更新日期:2018-01-11
  • Structure, gelation, and antioxidant properties of curcumin-doped casein micelle powder produced by spray-drying
    Food Funct. (IF 3.247) Pub Date : 2017-12-18
    Aya N. Khanji, Florentin Michaux, Jeremy Petit, Dominique Salameh, Toufic Rizk, Jordane Jasniewski, Sylvie Banon
    更新日期:2018-01-11
  • Effects of polysaccharides from purple sweet potatoes on immune response and gut microbiota composition in normal and cyclophosphamide treated mice
    Food Funct. (IF 3.247) Pub Date : 2017-12-13
    Chao Tang, Jian Sun, Bo Zhou, Changhai Jin, Jun Liu, Juan Kan, Chunlu Qian, Nianfeng Zhang
    更新日期:2018-01-11
  • Fortification of dark chocolate with microencapsulated phytosterols: chemical and sensory evaluation
    Food Funct. (IF 3.247) Pub Date : 2018-01-10
    Roberta Tolve, NICOLA CONDELLI, Marisa Carmela Carmela Caruso, Fabio Favati, Diego Barletta, Fernanda Galgano

    Chocolate is one of the most consumed delicacies in the world. Nowadays high-cocoa polyphenol-rich chocolate, probiotic chocolate, and prebiotic chocolate are getting more attention. In light of this, dark chocolate containing microencapsulated phytosterols (MP) was developed to reduce cholesterol in individuals. In particular, different dark chocolates containing 64, 72 and 85% of cocoa, fortified with 0, 5, 10 and 15% MP have been produced. The obtained chocolates were characterized by a particle size distribution lower than 30 µm and were stable from a chemical point of view. Specifically, peroxide values were always lower than 2 meq O2/kg of fat, also after three months of storage. Bioaccessibility of phytosterols was comparable with literature values and the antioxidant activity reached a value of 92 µg trolox/g chocolate for samples obtained from 85% of cocoa. Moreover, sensory evaluation demonstrated a positive effect on the acceptability of the functional chocolate produced and a significant effect of the information on the final samples acceptability.

    更新日期:2018-01-10
  • Metabolic fate of strawberry polyphenols after chronic intake in healthy older adults
    Food Funct. (IF 3.247) Pub Date : 2017-12-19
    Amandeep K. Sandhu, Marshall G. Miller, Nopporn Thangthaeng, Tammy M. Scott, Barbara Shukitt-Hale, Indika Edirisinghe, Britt Burton-Freeman
    更新日期:2018-01-10
  • 更新日期:2018-01-10
  • Milk-derived bioactive peptides protect against oxidative stress in a Caco-2 cell model
    Food Funct. (IF 3.247) Pub Date : 2018-01-10
    Federica Tonolo, Michele Sandre, Stefania Ferro, Alessandra Folda, Valeria Scalcon, Guido Scutari, Emiliano Feller, Oriano Marin, Alberto Bindoli, Maria Pia Rigobello

    Milk and milk-derived products are a relevant source of bioactive peptides which are also potential components of functional food. Bioactive peptides exert multiple actions including an antioxidant role. In the present paper, four synthetic peptides, (NPYVPR, AVPYPQR, KVLPVPEK, ARHPHPHLSFM) corresponding to milk-derived peptides, were studied. Although with different features, as revealed by RP-HPLC chromatography and MS analysis, the obtained peptides were shown to be taken up by Caco-2 cells arranged in an epithelial monolayer formation. The four peptides were all able to preserve cell viability against induced oxidative stress indicating that they might have a role on the control of oxidative stress. Therefore, estimation of total thiols and glutathione content were performed after cell treatment with oxidants like hydrogen peroxide (H2O2) or tert-butyl hydroperoxide (TbOOH). Peptides were able to prevent the decrease of both total thiols and glutathione induced by H2O2 or TbOOH and, in addition, they showed a protective effect on the thiol-related antioxidant enzymes thioredoxin reductase and glutathione reductase. Finally, they determined a decrease of ROS production induced by TbOOH in Caco-2 cells. The reported results highlight the relevant antioxidant role played by bioactive peptides in cells, which adds to other previously known properties.

    更新日期:2018-01-10
  • The effect of fucoidan on intestinal flora and intestinal barrier function in rats bearing breast cancer
    Food Funct. (IF 3.247) Pub Date : 2018-01-10
    Meilan Xue, Xinqiang Ji, Hui Liang, Ying Liu, Bing Wang, Lingling Sun, Weiwei Li

    Recent research have showed that the intestinal flora are related to the occurrence and progress of breast cancer. This study was to investigate the effect of fucoidan on intestinal flora and intestinal barrier function in rats with 7, 12-Dimethyl Benz[a]anthracene(DMBA)-induced breast cancers. Sixty female Sprague-Dawley rats were randomly assigned to control group, model group, and the F1 and F2 groups, which were fed fucoidan at concentrations of 200 and 400 mg/kg•bw (body weight), respectively. Intestinal histopathological analysis was performed and 16S rDNA high-throughput sequencing was used to provide an overview of the intestinal flora composition. The contents of D-lactic acid (D-LA), diamine oxidase (DAO) and endotoxin in plasma were detected by ELISA. Expression levels of the tight junction (TJ) proteins, phosphorylated p38 MAPK and ERK1/2 were measured using western blotting. Our results suggested the intestinal wall of model group were damaged. However, after fucoidan intervention, the villi were gradually restored. ELISA showed the levels of plasma endotoxin, D-LA and DAO decreased in F1 and F2 groups compared to those in model group. Fucoidan treatment also increased the expressions of ZO-1, Occludin, Claudin-1 and Claudin-8. Furthermore, the expression levels of phosphorylated p38 MAPK and ERK1/2 were upregulated in fucoidan treatment groups. The results of 16S rDNA high-throughput sequencing indicated that fucoidan increased diversity of intestinal microbiota and induced changes in microbial composition.with increased Bacteroidetes/Firmicutes phylum ratio. In conclusion, the supplement of fucoidan could improve the fecal microbiota composition and repair the intestinal barrier function. The study suggested the use of fucoidan as an intestinal flora modulator for potential prevention of breast cancer.

    更新日期:2018-01-10
  • Comparative studies on the hypolipidemic, antioxidant and hepatoprotective activities of catechins enriched Green and Oolong tea in a double-blind clinical trial
    Food Funct. (IF 3.247) Pub Date : 2018-01-10
    Kamesh Venkatakrishnan, Hui-fang Chiu, Ju-Chun Cheng, Ya-Hui Chang, Yan-Ying Lu, Yi-Chun Han, You-Cheng Shen, Kun-Shun Tsai, Chin Kun Wang

    This study was aimed to compare the beneficial effect of catechin-enriched green tea and Oolong tea on mildly hypercholesterolemic subjects. Sixty mild hypercholesterolemic subjects (180-220 mg/dL) were enrolled and divided into three groups as catechin-enriched green tea (CEGT), catechin-enriched oolong tea (CEOT) or placebo. Subjects were instructed to drink (2 x 300 mL) of CEGT (780.6 mg of catechin), CEOT (640.4 mg of catechin) or placebo beverage for 12 weeks. Drinking CEGT and CEOT significantly decreased (p < 0.05) the body weight, fat, and BMI, lipid peroxidation as well as lipid profile (TC, LDL-c, HDL-c, and TG). Also, intervention with CEGT and CEOT significantly improved (p < 0.05) the oxidative indices (TEAC, GSH) and antioxidant enzymes (SOD, CAT, GPx, GR). Moreover, ultrasound examination endorsed the hepatoprotective activity of CEGT and CEOT by reverting mild fatty liver to the normal hepatic condition because of antioxidant and hypolipidemic activities. To summarize, both CEGT and CEOT showed similar antioxidant and hepatoprotective activities. However, CEOT displayed superior lipid-lowering activity than CEGT or placebo, and hence it could be urged to amend the wellness condition of mildly hypercholesterolemic subjects.

    更新日期:2018-01-10
  • Oral declines and mastication deficiencies cause alteration of food bolus properties
    Food Funct. (IF 3.247) Pub Date : 2018-01-10
    Marie-Agnès PEYRON, Véronique Sante-Lhoutellier, Olivier François, Martine Hennequin

    In the elderly, masticatory function often presents failure in certain oral tasks due to impairment such as decline in muscular force, jaw or tongue motility, neuro-muscular coordination, tooth damage, malocclusion and saliva production. Great disparity is observed in the various and potentially cumulative oral declines that occur with ageing. Such difficulties may have an impact on food consumption and nutritional status. To obtain better understanding of the consequences of several oral deficiencies, a series of swallowable boluses were prepared in vitro with the AM2 masticator apparatus with normal and deficient programming. Physiological normal mastication (NM) was simulated using in vivo data from healthy subjects. Chewing deficiencies were reproduced by alteration of NM programming to perform different levels and combinations of force loss, lack of saliva and decrease in the motility of oral elements. Poultry meatballs were used as test-food. Particle size distribution in the food bolus was measured by sieving and rheological features (hardness, cohesiveness and elasticity) were assessed with a TPA test. Compared to the NM outcome, significant and gradual deterioration of the food bolus was observed and associated with alteration in force, saliva and motility. Combinations of several failures led to greater or cumulative deficiencies in swallowable bolus properties. For the elderly presenting a high prevalence of various oral injuries, tailoring textured food cannot be ignored as a solution for remedying deficiencies and favoring the formation of a safe-swallowable bolus, which is an essential vector of nutrients. Knowing the impacts of oral injuries on the food bolus is obviously a requisite for developing diet strategies, including nutritional items for specific populations.

    更新日期:2018-01-10
  • Purification, characterization and anti-fatigue activity of polysaccharide fractions from okra (Abelmoschus esculentus (L.) Moench)
    Food Funct. (IF 3.247) Pub Date : 2018-01-09
    Han Gao, Wencheng Zhang, Bingsong Wang, Ailing Hui, Biao Du, Tingting Wang, Ling Meng, Huixi Bian, Zeyu Wu

    The aim of this study was to investigate the anti-fatigue activity of polysaccharide fractions from Abelmoschus esculentus (L.) Moench (AE) in mice. After crude polysaccharide (CAEP) extracted from AE and purified by DEAE cellulose-52 column, two polysaccharide fractions (AEP-1 and AEP-2) were obtained. The structural analysis suggested that AEP-1 and AEP-2 were a RG-I polysaccharide and an AG-II polysaccharide, respectively. According to the results of weight-loaded swimming test, compared with negative control group, the CAEP, AEP-1 and AEP-2 treatment groups could prolong the swimming time, decrease serum urea nitrogen (SUN) and blood lactic acid (BLA), and increase hepatic glycogen (HG) and muscle glycogen (MG), which indicated that okra polysaccharides have an effective anti-fatigue activity. Furthermore, our study exhibited the anti-fatigue mechanism of okra polysaccharide was correlated with retarding the accumulation of creatine kinase (CK) and lactate dehydrogenase (LDH) in serum, and enhancing succinate dehydrogenase (SDH), adenosine triphosphate (ATP) and adenosine triphosphatase (ATPase) levels. In addition, the anti-fatigue activity of AEP-1 was stronger than that of AEP-2, significantly better than that of CAEP. Therefore, AEP-1 and AEP-2 may be the main active anti-fatigue functional substance of AE.

    更新日期:2018-01-09
  • Lactobacillus plantarum CCFM10 alleviating oxidative stress and restoring the gut microbiota in D-galactose-induced aging mice
    Food Funct. (IF 3.247) Pub Date : 2017-12-13
    Jichun Zhao, Fengwei Tian, Shuang Yan, Qixiao Zhai, Hao Zhang, Wei Chen
    更新日期:2018-01-09
  • Dietary supplementation of defatted kenaf (Hibiscus cannabinus L.) seed meal and its phenolics–saponins rich extract effectively attenuates diet-induced hypercholesterolemia in rats
    Food Funct. (IF 3.247) Pub Date : 2017-12-04
    Kim Wei Chan, Maznah Ismail, Norhaizan Mohd Esa, Mustapha Umar Imam, Der Jiun Ooi, Nicholas M. H. Khong
    更新日期:2018-01-09
  • Niga-ichigoside F1 ameliorates high-fat diet-induced hepatic steatosis in male mice by Nrf2 activation
    Food Funct. (IF 3.247) Pub Date : 2017-12-21
    Shu-Fang Xia, Jing Shao, Shu-Ying Zhao, Yu-Yu Qiu, Li-Ping Teng, Wei Huang, Shan-Shan Wang, Xiang-Rong Cheng, Yu-Yu Jiang
    更新日期:2018-01-08
  • 更新日期:2018-01-08
  • Effects of volatile oil from ginger on the murine B16 melanoma cells and its mechanism
    Food Funct. (IF 3.247) Pub Date : 2018-01-05
    Lixia Wang, Jia Qian, Linan Zhao, Shaohua Zhao

    In this study, the inhibitory effects of volatile oil from ginger on melanogenesis and its antioxidant characteristics were investigated. The effects of volatile oil from ginger on cell proliferation, melanin content and tyrosinase activity were determined to use microplate reader. And the expression of melanogenesis- related protein was determined by Western blotting. The results indicated that the tested concentrates of volatile oil from ginger showed inhibitory effects on cell proliferation and melanogenesis. It revealed that volatile oil from ginger exhibited the apparent capacities of scavenging ROS and lipid peroxidation. Furthermore, volatile oil from ginger improved the activities of GSH, SOD and CAT in B16 melanoma cells. These results demonstrated that volatile oil from ginger suppressed melanin synthesis through its antioxidant properties and the inhibitory effects on tyrosinase activity and melanogensis-related proteins. Hence, volatile oil from ginger could be used as an effective skin-whitening agent applied in food industry.

    更新日期:2018-01-05
  • In vitro fermentation gas kinetics and end-products of soluble and insoluble cereal flour dietary fibres are similar
    Food Funct. (IF 3.247) Pub Date : 2017-12-20
    Penny Comino, Barbara A. Williams, Michael J. Gidley
    更新日期:2018-01-05
  • Effects of a combined intervention with lentil protein hydrolysate and a mixed training protocol on lipid metabolism and hepatic markers of NAFLD in Zucker rats.
    Food Funct. (IF 3.247) Pub Date : 2018-01-04
    Rosario Martínez, Garifallia Kapravelou, Ana Donaire, Carlos López Chaves, Francisco Arrebola, Milagros Galisteo, Samuel Cantarero-Malagón, Pilar Aranda, Jesus Maria M Porres Foulquie, M. Lopez-Jurado

    Metabolic syndrome is a cluster of metabolic alterations characterized by central obesity, dyslipidemia, elevated plasma glucose, insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD). In this study, a combined intervention of lentil protein hydrolysate and a mixed training protocol was assessed in an animal experimental model of genetic obesity and metabolic syndrome. Thirty-two male obese and 32 lean Zucker rats were allocated to eight different experimental groups. Rats performed a mixed exercise protocol or had a sedentary lifestyle and were administrated a lentil protein hydrolysate or placebo. Daily food intake, weekly body weight gain, plasma parameters of glucose and lipid metabolism, body composition, hepatic weight, total fat content and fatty acid profile, as well as gene expression of lipogenic and lipolytic nuclear transcription factors and their target genes were measured. Obese Zucker rats exhibited higher body and liver weight and fat content compared to their lean counterparts. Such alterations were related to modifications in aerobic capacity, plasma biochemical parameters of glucose and lipid metabolism, hepatic fatty acid profile and gene expression of nuclear transcription factors SREBP1c, PPAR, LXR and associated lipogenic and lipolytic enzymes. The interventions tested did not affect body weight gain but improved the aerobic capacity, reduced hepatomegalia and steatosis associated to NAFLD and relieved the adverse effects produced by this condition in the glucose and lipid metabolism through the modulation in expression of different genes involved in diverse metabolic pathways.

    更新日期:2018-01-04
  • 更新日期:2018-01-04
  • Phenolic profiles of eight olive cultivars from Algeria: effect of Bactrocera oleae attack
    Food Funct. (IF 3.247) Pub Date : 2017-12-12
    Lynda Medjkouh, Abderezak Tamendjari, Rita C. Alves, Rahima Laribi, M. Beatriz P. P. Oliveira
    更新日期:2018-01-04
  • Hypolipidemic effect and protection ability of liver-kidney functions of melanin from Lachnum YM226 in high-fat diet fed mice
    Food Funct. (IF 3.247) Pub Date : 2017-12-01
    Fang Shi, Jinglei Li, Liuqing Yang, Guohua Hou, Ming Ye
    更新日期:2018-01-04
  • Metagenomics approach to the intestinal microbiome structure and function in high fat diet-induced obesity mice fed with oolong tea polyphenols
    Food Funct. (IF 3.247) Pub Date : 2018-01-03
    Mei Cheng, Xin Zhang, Jieyu Zhu, Lu Cheng, Jinxuan Cao, Zufang Wu, Peifang Weng, Xiaojie Zheng

    To investigate the modulatory effect of oolong tea polyphenols (OTP) on intestinal microbiota, OTP was prepared by column chromatography and its influence on gut flora structure was analyzed by high-throughput sequencing with a human flora-associated high fat diet (HFD) induced obesity mouse model. We observed a robust increase in bacterial biodiversity and the abundance of genera known to be butyrate- and acetate-producing bacteria. A large increase in Bacteroidetes with a decrease in Firmicutes was observed after the administration of OTP for 4 weeks, and the corresponding decrease in the Firmicutes/Bacteroidetes ratio reflected the positive modulatory effect of OTP on the intestinal microbiota. In addition, KEGG pathways for the biosynthesis of amino acids, carbon metabolism, and the ribosome were among the most differentially expressed genes after OTP intervention. The current study revealed that OTP rich in tea catechins, especially O-methylated derivatives, may have prebiotic-like activity and can be used as a functional food component with potential therapeutic utility to prevent obesity-related metabolic disorders by manipulating the intestinal microbiota.

    更新日期:2018-01-03
  • Structural characterization of two endopolysaccharides from Phellinus sp. and their immunologic effects by intragastric administration in a healthy mammalian model
    Food Funct. (IF 3.247) Pub Date : 2018-01-03
    Xiao-kui Ma, Yao Ma, Eric Charles Peterson, Wenying Guo, Zhongyu Li, Yu Li

    Two purified endopolysaccharides derived from cultured Phellinus sp., individually named as SHIP-1 and 2, were structurally characterized, along with an evaluation of their in vivo influential immunomodulatory activity in a healthy mammalian model. The structure of SHIP-1 was mainly composed of →4)-α-D-Fucp-(1→, →3,6)-α-D-Araf-(1→ and →2,4)-β-D-Galp-(→, with four residuals of α-D-Manp-(1→ and one α-D-Glcp-(1→ as sidegroups, while the planar structure and the heteronuclear multiple-bond correlation of SHIP-2 was not able to be analyzed. Biochemical analysis in the healthy mice model demonstrated that SHIP-1 increased concentrations of the detected cytokines in a dosage-dependent manner but not in a time dependent way. SHIP-2 exerted a positive effect in a dose-dependent manner over time for interferon gamma (IFN-γ) and interleukins (IL)-2 cytokine production at elevated dosages of 200, or 350 mg kg−1 d−1, while IFN-alpha(α) and IL-4 production was observed only in a dosage dependent manner even at high dosages. Thus, SHIP-1 and 2 significantly improved the immune response through intragastric administration of the tested high dosages by increasing the production of cytokines in the healthy mice, and these polysaccharides could be possibly used as an immunopotentiator in healthy foods or dietary supplement.

    更新日期:2018-01-03
  • Ameliorative role of camel whey protein and rosuvastatin on induced dyslipidemia in mice
    Food Funct. (IF 3.247) Pub Date : 2018-01-02
    nashwa Ahmed Ahmed Elshinnawy, sahar Sobhy sobhy abd el-halem, nawal Zakaria haggag, Gamal Badr

    The incidence of overweight is rapidly increasing throughout the world. Dyslipidemia is a major risk factor for a number of chronic diseases, including diabetes and cardiovascular diseases.This work presents a novel approach to study the activity of camel whey protein (WP) as a cheap dietary protein substance extracted from camel milk producing satiety, helping in building muscles with antioxidant and anti-inflammatory properties. Mice model suffering from dyslipidemia as a result of feeding on high fat-cholesterol diet for 8 weeks administrated either camel WP and/or rosuvastatin for 4 weeks. Dyslipidemia revealed significant increase in anthropometrical measurements, levels of glucose, insulin, cholesterol, triglycerides, low-density lipoprotein, total leucocyte count, inflammatory cytokines and reactive oxygen species accompanied by a significant elevation in activating transcription factor-3 and inducible nitric oxide synthase expressions. These alterations were correlated with a profound reduction in high-density lipoprotein, peroxisome proliferator-activated receptor alpha and adiponectin along with a decrease in liver and muscle mitochondrial proteins. Rosuvastatin treatment to mice suffering from dyslipidemia in combination with camel WP for 4 weeks ameliorated these parameters. Notably, animals treated with both camel WP and rosuvastatin exhibited a remarkable decrease in the incidence of dyslipidemia. Also, camel WP succeeded to overcome the therapeutic drawback posed from rosuvastatin therapy alone with minimal side effects.

    更新日期:2018-01-02
  • Quercetin enhances the antitumor effect of trichostatin A and suppresses muscle wasting in tumor-bearing mice
    Food Funct. (IF 3.247) Pub Date : 2017-12-18
    Shu-Ting Chan, Cheng-Hung Chuang, Yi-Chin Lin, Jiunn-Wang Liao, Chong-Kuei Lii, Shu-Lan Yeh
    更新日期:2018-01-02
  • An altered tissue distribution of flaxseed lignans and their metabolites in Abcg2 knockout mice
    Food Funct. (IF 3.247) Pub Date : 2017-12-11
    Dafne García-Mateos, Rocío García-Villalba, Jon A. Otero, José A. Marañón, Juan C. Espín, Ana I. Álvarez, Gracia Merino
    更新日期:2018-01-02
  • Sea cucumber saponin liposomes ameliorate obesity-induced inflammation and insulin resistance in high-fat-diet-fed mice
    Food Funct. (IF 3.247) Pub Date : 2017-12-11
    Cheng Chen, Xiuqing Han, Ping Dong, Zhaojie Li, Teruyoshi Yanagita, Changhu Xue, Tiantian Zhang, Yuming Wang
    更新日期:2018-01-02
  • 更新日期:2018-01-02
  • Comparative study of the effects of phosphatidylcholine rich in DHA and EPA on Alzheimer's disease and the possible mechanisms in CHO-APP/PS1 cells and SAMP8 mice
    Food Funct. (IF 3.247) Pub Date : 2017-12-06
    Hongxia Che, Miaomiao Zhou, Tiantian Zhang, Lingyu Zhang, Lin Ding, Teruyoshi Yanagita, Jie Xu, Changhu Xue, Yuming Wang
    更新日期:2018-01-02
  • Interactions of flavonoids with α-amylase and starch slowing down its digestion
    Food Funct. (IF 3.247) Pub Date : 2017-12-05
    Umeo Takahama, Sachiko Hirota
    更新日期:2018-01-02
  • Epidermal growth factor and transforming growth factor-α in human milk of different lactation stages and different regions and relationship with maternal diet
    Food Funct. (IF 3.247) Pub Date : 2018-01-02
    Mengqing Lu, Jiajing Jiang, Kejian Wu, D. Li

    The aim of the present study was to investigate the concentration of EGF and TGF-α in breast milk among different lactations and different regions, and further analyze their association with maternal dietary intake. Breast milk samples and 24-hour food records were obtained from lactating mothers on day 1 (colostrum), day 14 (transitional milk) and day 42 (mature milk) from Hangzhou (n = 76), Lanzhou (n = 76) and Beijing (n = 76), China. Concentrations of EGF and TGF-α in breast milk were determined by enzyme-linked immunosorbent assay (ELISA). Breast milk concentration of EGF was significantly decreased over lactation periods (p < 0.001), while TGF-α was significantly increased over lactation periods (p < 0.001). EGF concentration in breast milk was significantly higher in Lanzhou than Beijing and Hangzhou (p < 0.001), while TGF-α concentration was significantly higher in Beijing than Lanzhou and Hangzhou (p < 0.001). The concentration of EGF in breast milk was significantly negatively associated with dietary intake of protein (p = 0.042), total energy (p = 0.031), vegetables (p = 0.002), fruits (p < 0.001), soy products (p = 0.001) and dairy foods (p < 0.001), while TGF-α was significantly positively associated with dietary intake of carbohydrate (p = 0.023) and dairy products (p = 0.011), and significantly negatively associated with dietary intake of protein (p = 0.008) and meat (p = 0.016). In conclusion, EGF and TGF-α concentrations in breast milk were greatly varied by regions and lactation periods, and significantly influenced by maternal dietary intake.

    更新日期:2018-01-02
  • Probiotic/prebiotic correction for adverse effects of iron fortification on intestinal resistance to Salmonella infection in weaning mice
    Food Funct. (IF 3.247) Pub Date : 2018-01-02
    Feifei Lin, Haohao Wu, Mingyong Zeng, Guangli Yu, shiyuan dong, Huicheng Yang

    Iron fortification has been associated to modestly increase diarrhea risk among children. Here, we investigate the correction for this unwanted side effect with probiotic/prebiotic supplementation in weaning mice. Iron fortification with 250 ppm and 500 ppm ferrous sulfate for 30 days significantly increased species richness of mouse gut microbiota compared to controls. The 500 ppm-FeSO4 diet caused a significantly decreased abundance of potentially beneficial Lactobacillus. During infection with the foodborne pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium), mice on the 500 ppm-FeSO4 diet showed earlier appearance of poisoning symptoms, higher rates of weight and appetite loss, and lower survival rates, all of which were effectively reversed by the supplementation with a probiotic (Lactobacillus acidophilus) or a prebiotic (inulin) for 7 days before infection. Iron fortification with 500 ppm ferrous sulfate also increased fecal shedding and spleen and liver load of viable S. Typhimurium, suggesting its promoting effect on pathogen colonization and translocation, and this negative effect was found to be well corrected by the supplementation with Lactobacillus acidophilus or inulin. Light and transmission electron microscopic observation on ileal villus structure revealed histopathological impairment of intestine by iron fortification with both 250 ppm and 500 ppm ferrous sulfate, and the intestinal lesions were markedly alleviated by the supplementation with Lactobacillus acidophilus or inulin. These results provide experimental evidence for the increased diarrhea risk upon iron fortification with high pathogen load, and demonstrate that probiotic or prebiotic supplementation can be used to eliminate the potential harm of iron fortification on gut health.

    更新日期:2018-01-02
  • A comparison of the sensory and rheological properties of different cellulosic fibres for food
    Food Funct. (IF 3.247) Pub Date : 2017-12-29
    Deepa Agarwal, Tim Foster, Louise Hewson

    The impact of different cellulosic microstructures formed by highly entangled fibre networks were studied for food applications as dietary fibre. This paper reports the impact of microstructure on the rheological and sensory behaviour of the aqueous suspensions of particulate and fibrillated forms of softwood cellulosic fibres, and were compared with citrus fibre. An aqueous suspension of cellulosic fibres shows stable viscoelastic gel-like behaviour as a function of frequency. The particulate form of cellulosic fibres showed lowest shear viscosity as compared to the entangled network system at comparable concentrations. To provide further insight into the relationship between the structure of cellulosic fibre systems and perception of salt taste in aqueous suspensions of softwood cellulosic fibres (fibrillated and particulate form) and citrus fibres with matched shear viscosities were studied. A hypothesis to explain why softwood cellulosic fibre (CTE) with entangled network structure prolongs the taste perception is presented.

    更新日期:2017-12-31
  • Quantitative N-glycoproteomics of milk fat globule membrane in human colostrum and mature milk reveals changes in protein glycosylation during lactation
    Food Funct. (IF 3.247) Pub Date : 2017-12-29
    Xueyan Cao, Shimo Kang, Mei Yang, Weixuan Li, Shangyi Wu, Hongjiao Han, Lingshuai Meng, Rina Wu, Xiqing Yue

    Milk fat globule membrane (MFGM) proteins have recently gained increasing attention, due to their significant biological function. However, the glycosylation of proteins in human MFGM during lactation has not been studied in detail. In this study, through mass spectroscopy-based N-glycoproteomics, we analyzed protein glycosylation of human MFGMs. A total of 912 N-glycosylation sites on 506 N-glycoproteins were identified in human colostrum and mature milk MFGM. Among them, 220 N-glycoproteins with 304 N-glycosylation sites were differentially expressed in colostrum and mature milk MFGM. Gene Ontology (GO) analysis revealed various biological processes, cellular components, and molecular functions of the differentially expressed N-glycoproteins. Specifically, these glycoproteins were involved in biological processes such as single-organism process, biological regulation, regulation of biological process, response to stimulus and localization; were cellular components in organelles, membranes, and the extracellular region; and had different molecular functions such as protein binding, receptor activity, and hydrolase activity. KEGG pathway analysis suggested that the majority of the differentially expressed N-glycoproteins were associated with phagosome, cell adhesion molecules and some disease-related pathways. Our results provide an in-depth understanding of the quantitative changes in N-glycosylation of proteins in human colostrum and mature MFGMs, and extend our knowledge of the N-glycoproteome and of the distribution of N-glycosylation sites in human MFGM during lactation, providing insight into the biological functions of the highlighted glycoproteins.

    更新日期:2017-12-31
  • Protective effects of Ganoderma atrum polysaccharide against acrylamide Induced oxidative damage via a mitochondria mediated intrinsic apoptotic pathway in IEC-6 cells
    Food Funct. (IF 3.247) Pub Date : 2017-12-27
    Guoyong Jiang, Lulu Zhang, Hui Wang, Qian Chen, Xiaolin Wu, Xiaoli Yan, Yi Chen, Ming-Yong Xie

    The preventive role of a purified Ganoderma atrum polysaccharide PSG-1-F2 as a new dietary antioxidant against the intestinal toxicity of acrylamide (ACR) were investigated in vitro. Our results showed that ACR could induce oxidative stress in IEC-6 cells by overproduction of the reactive oxygen species (ROS) and malondialdehyde (MDA), and as well as reduction in activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). In addition, induction of mitochondria-mediated intrinsic apoptotic pathway by ACR was evidenced by the events of loss of mitochondrial membrane potential, bax/bcl-2 dysregulation, cytochrome c release, and activation of caspases 3. Interestingly, PSG-1-F2 was able to suppress ACR toxicity by improving the redox status of IEC-6 cells and by attenuating mitochondria-mediated apoptosis. Its protective effect was even superior to the clinically used antioxidant N-acetylcysteine (NAC). This study uniquely introduces PSG-1-F2 as a potential inhibitor of ACR -induced stress and toxicities.

    更新日期:2017-12-27
  • Asiatic acid suppresses neuroinflammation in BV2 microglia via modulation of Sirt1/NF-κB signaling pathway
    Food Funct. (IF 3.247) Pub Date : 2017-12-27
    Yisong Qian, Zhaochen Xin, Yan-Ni Lv, Ziwei Wang, Li Zuo, Xiang Huang, Yunman Li, Hongbo Xin

    Asiatic acid, a triterpenoid derived from Centella asiatica, has been found to exhibit multiple bioactivities. In this study, we investigated the effects of asiatic acid on lipopolysaccharide (LPS)-induced neuroinflammation and explored the mechanism of its action in BV2 microglia. We found that asiatic acid (0.1 to 100 μM) treatment significantly attenuated nitric oxide (NO) production and inhibited inducible nitric oxide synthase (iNOS) expression in a concentration-dependent manner following LPS exposure. Asiatic acid reduced LPS-induced expression and secretion of inflammatory cytokines, including tumor necrosis factor factor-α (TNF-α), interleukin -1β (IL-1β) and interleukin-6 (IL-6) in BV2 cells. In addition, asiatic acid enhanced Sirt1 expression, reduced NF-κB p65 acetylation, and suppressed NF-κB activation after LPS stimulation. However, EX-527, an inhibitor of Sirt1, abolished the inhibitory effects of asiatic acid on LPS-stimulated microglia activation. These findings suggest that asiatic acid prevents LPS-induced neuroinflammation via regulating Sirt1/NF-κB signaling pathway.

    更新日期:2017-12-27
  • Stability and digestibility of one- or bi-layered medium chain triglyceride emulsions with gum Arabic and whey proteins isolates by pancreatic lipase in vitro
    Food Funct. (IF 3.247) Pub Date : 2017-12-22
    Xiaolin Yao, Yu Chen, Meng Shu, Kun Zhang, Zhiming Gao, Ying Kuang, Yapeng Fang, Katsuyoshi Nishinari, Glyn O. Phillips, Fatang Jiang

    The interfacial engineering approaches have been used to design functional foods so as to control lipase-induced digestion of emulsified lipids and release of bioactive lipophilic components in gastrointestinal tract. In this study, the emulsion droplets interface stabilized with gum arabic (GA) and whey protein isolate (WPI) were prepared with mixing or sequential adsorption. WPI/GA intramolecular soluble complexes (ISCs) have superior emulsifying properties in stabilizing oil-in-water emulsions. The impact of the interfaces for WPI/GA ISCs-layered (one layered) and double-layered by sequential deposition of WPI or GA on the lipolysis of emulsions was investigated using in vitro simulated gastrointestinal model. The transglutaminase and dithiothreitol were introduced to crosslink the interfacial protein and improved the interfacial stability. The ISCs-layered emulsion was less stable to aggregation than the double-layered ones in simulated gastric fluid due to dissociation of ISCs caused by the electrostatic screening of ions and proteolysis of interfacial protein driven by pepsin. The ISCs-layered emulsion conferred a significant slower rate and extent of lipids digestion compared to the double-layered emulsions post gastric proteolysis (P < 0.05). It is presumable for ISCs-layered emulsion that the destabilization to aggregation and coalescence within the simulated gastrointestinal fluids, and the sterically hindrance of the robust and thick interfacial layer might contribute to delaying FFA release. It suggests that both the initial interfacial properties and the stability of the emulsified lipid droplets within the simulated gastrointestinal fluids played an important role in determining the rate and extent of lipid digestion. It is predictable that directed destabilization of emulsified lipids using interfacial engineering approaches has potential for modifying lipid digestibility or bioactive release at specific sites within the gastrointestinal tract.

    更新日期:2017-12-22
  • 更新日期:2017-12-22
  • Production, optimisation and characterisation of angiotensin converting enzyme inhibitory peptides from sea cucumber (Stichopus japonicus) gonad
    Food Funct. (IF 3.247) Pub Date : 2017-12-11
    Chan Zhong, Le-Chang Sun, Long-Jie Yan, Yi-Chen Lin, Guang-Ming Liu, Min-Jie Cao
    更新日期:2017-12-22
  • Anti-diabetic activity of a polyphenol-rich extract from Phellinus igniarius in KK-Ay mice with spontaneous type 2 diabetes mellitus
    Food Funct. (IF 3.247) Pub Date : 2017-12-06
    Sijian Zheng, Shihao Deng, Yun Huang, Mi Huang, Ping Zhao, Xinhua Ma, Yanzhang Wen, Qiang Wang, Xinzhou Yang
    更新日期:2017-12-22
  • Home food preparation techniques impacted the availability of natural antioxidants and bioactivities in kale and broccoli
    Food Funct. (IF 3.247) Pub Date : 2017-12-01
    Lu Yu, Boyan Gao, Yanfang Li, Thomas T. Y. Wang, Yinghua Luo, Jing Wang, Liangli (Lucy) Yu
    更新日期:2017-12-22
  • 更新日期:2017-12-21
  • Evaluation of protective effect of different dietary fibers on polyphenolic profile stability of maqui berry (Aristotelia chilensis (Molina) Stuntz) during in vitro gastrointestinal digestion
    Food Funct. (IF 3.247) Pub Date : 2017-12-18
    Manuel Viuda-Martos, Raquel Lucas-Gonzalez, Carmen Ballester-Costa, José A. Pérez-Álvarez, Loreto A. Muñoz, Juana Fernández-López
    更新日期:2017-12-21
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
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