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  • Momordica charantia extracts protect against inhibition of endothelial angiogenesis by advanced glycation endproducts in vitro
    Food Funct. (IF 3.289) Pub Date : 2018-10-15
    Ali Aljohi, Sabine Matou-Nasri, Donghui Liu, Nadia Al-Khafaji, Mark Slevin, Nessar Ahmed
    更新日期:2018-10-15
  • Chlorogenic acid methyl ester exerts strong anti-inflammatory effects via inhibiting the COX-2/NLRP3/NF-κB pathway
    Food Funct. (IF 3.289) Pub Date : 2018-10-15
    Lang Zhang, han wen su, ya fan, li wu, yu ying huang, lei zhao, bing han, guang wen shu, Meixian Xiang, Jin-Ming Yang

    The objective of this study was to investigate the anti-inflammatory effect of chlorogenic acid methyl ester (CME) and the molecular mechanism involved, through using the non-infectious inflammation and infectious inflammation animal models as well as the lipopolysaccharide (LPS)-stimulated mouse macrophage RAW264.7 cell models. Our results demonstrated that CME markedly inhibited ear swelling, paw swelling and granuloma swelling, and decreased intraperitoneal capillary permeability in non-infectious inflammation. Moreover, CME significantly alleviated the pathological damage of the lung tissue, reduced the levels of PGE2 and IL-1β in the serum and the protein expression levels of related-inflammatory factors in the lung tissue of the LPS-induced mice with acute lung injury (ALI). In addition, CME affected RAW264.7 cells cycle and inhibited the protein expressions of COX-2 and NLRP3 and prevented the phosphorylation of NF-κB p65 in RAW264.7 cells treated with LPS. These observation not only validated the anti-inflammatory effects of CME, but also revealed the underlying molecular basis, which involves the down-regulation of the expression of inflammatory factors and blockade of the COX-2/NLRP3/NF-κB signaling pathway.

    更新日期:2018-10-15
  • Spice-derived phenolic, malabaricone B induces mitochondrial damage in lung cancer cells via a p53-independent pathway
    Food Funct. (IF 3.289) Pub Date : 2018-09-18
    Mrityunjay Tyagi, Biswanath Maity, Bhaskar Saha, Ajay Kumar Bauri, Mahesh Subramanian, Subrata Chattopadhyay, Birija Sankar Patro
    更新日期:2018-10-15
  • Bio-distribution and interaction with dopamine of fluorescence nanodots from roasted chicken
    Food Funct. (IF 3.289) Pub Date : 2018-10-12
    Xunyu Song, Haitao Wang, Run Zhang, Chenxu Yu, Mingqian Tan

    The potential health risks of food-borne nanoparticles are of great concerns to public health. In this work, the formation and physicochemical properties of a class of fluorescence nanodots (FNDs) in roasted chicken were investigated. It was found that as the roasting temperature increased from 200 to 300 °C the size of the FNDs decreased significantly, from 17.1 to 2.1 nm. The FNDs, which mainly contain carbon (65%), are strongly fluorescent under ultraviolet light, exhibiting an excitation-dependent emission behavior. The fluorescence quantum yields of the FNDs occurred at 200, 250, 300 °C, and were 6.71±0.21, 12.85±0.34 and 17.46±0.42%, respectively. These FNDs not only could be taken up by live cells and dispersed within the cytoplasm, but also could pass the blood-brain barrier (BBB) and accumulated in the brain of mice after oral feeding. The results of the fluorescence and Fourier transform infrared (FTIR) spectroscopy analysis clearly indicated that the FNDs can interact with the neurotransmitter dopamine in vitro through the formation of fluorescent conjugates. The relative cell viability was decreased by 33% corresponding to FND-300 at a concentration of 4 mg/mL. These results confirmed the presence of FNDs in roasted chicken and revealed their potential bioeffects on human health, which calls for more research and evaluation.

    更新日期:2018-10-12
  • Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models
    Food Funct. (IF 3.289) Pub Date : 2018-10-12
    Ran Wei, Limin Mao, Ping Xu, Xinghai Zheng, Robert M. Hackman, Gerardo G. Mackenzie, Yuefei Wang
    更新日期:2018-10-12
  • Effects of the intake of white wheat bread added with garlic and resistant starch: action on calcium bioavailability and metabolic parameters of growing Wistar rats
    Food Funct. (IF 3.289) Pub Date : 2018-09-27
    Adriana R. Weisstaub, María Victoria Salinas, María Jimena Correa, Magalí Barchuk, Gabriela Berg, Angela Zuleta
    更新日期:2018-10-12
  • The functional and organoleptic characterization of a dairy-free dessert containing a novel probiotic food ingredient
    Food Funct. (IF 3.289) Pub Date : 2018-09-27
    C. E. Genevois, A. P. Castellanos Fuentes, S. K. Flores, M. F. de Escalada Pla
    更新日期:2018-10-12
  • Explorative investigation of the anti-glycative effect of a rapeseed by-product extract
    Food Funct. (IF 3.289) Pub Date : 2018-10-04
    Marta Navarro, Bruna de Falco, Francisco J. Morales, Despoina Daliani, Alberto Fiore
    更新日期:2018-10-11
  • Emerging opportunities in exploring the nutritional/functional value of amaranth
    Food Funct. (IF 3.289) Pub Date : 2018-09-24
    Laylla Marques Coelho, Pedro Miguel Silva, Joana T. Martins, Ana C. Pinheiro, António A. Vicente
    更新日期:2018-10-11
  • Characterization of transglutaminase from Bacillus subtilis and its cross-linking function with a bovine serum albumin model
    Food Funct. (IF 3.289) Pub Date : 2018-09-21
    Yihan Liu, Lin Huang, Dong Zheng, Yu Fu, Mengying Shan, Yanzhen Li, Zehua Xu, Leibo Jia, Wenhang Wang, Fuping Lu
    更新日期:2018-10-11
  • Oleogel-structured composite for the stabilization of ω3 fatty acids in fish oil
    Food Funct. (IF 3.289) Pub Date : 2018-10-10
    Michelle Lee, Xiaofei Jiang, J. Thomas Brenna, Alireza Abbaspourrad

    This study examined the encapsulation and stabilization of ɷ3 in fish oil into a multi-compartment system consisting of β-cyclodextrins (β-CD) complexation within an oleogel structure, which was further coated with a layer of whey protein isolate (WPI). The formation of β-CD-fish oil complex was confirmed by TGA and FTIR. Particle size and ζ-potential of the oleogel-based O/W emulsion did not change significantly over a 28-day storage period under different pH conditions (pH 3.5-7) and NaCl concentrations (50-500 mg/L). The WPI-coated oleogel and β-CD-fish oil complex were subjected to UVC light exposure and quantified by their eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) contents. Results indicated that more than 50 wt% of both EPA and DHA were retained after a 4-h UV exposure period in the WPI-coated system. In addition, sensory evaluation results showed a decreased fish oil odor in the WPI-coated oleogel samples. Overall, the results from this study demonstrated that this oleogel-structured composite incorporating β-CD-fish oil complexes can be formed successfully to retain lipophilic components with decreased undesirable fish oil odor.

    更新日期:2018-10-11
  • Effect of Grifola frondosa 95% ethanol extract on lipid metabolism and gut microbiota composition in high-fat diet-fed rats
    Food Funct. (IF 3.289) Pub Date : 2018-10-10
    Yu-Yang Pan, Feng Zeng, Wei-Ling Guo, Tian-Tian Li, Rui-Bo Jia, Zi-Rui Huang, Xu-Cong Lv, Jia-Chao Zhang, Bin Liu

    This study aimed to investigate the effects of 95% ethanol extract of G. frondosa (GF95) on lipid metabolism and gut microbiota composition in high-fat diet (HFD) fed rats. UPLC/Q-TOF MS indicated that GF95 was enriched with flavone, fatty acid and so on. Meanwhile, we found that body weight, serum lipid or liver index (total cholesterol, triglyceride, and low density lipoprotein cholesterol) levels were significantly decreased in GF95-treated HFD-fed rats. Furthermore, GF95 treatment regulated mRNA expressions levels involved in lipid metabolism. GF95 consumption significantly enhanced the excretion of bile acids in the cecum. Besides, in this study, a higher abundance of Butyricimonas genus was revealed in GF95 group, which is highly related to the highest production of short-chain fatty acids in the caecum contents among the experimental groups. Interestingly, results’ from network analysis showed that Butyricimonas were negatively correlated with serum and liver lipid profiles.

    更新日期:2018-10-11
  • Protective effects of enhanced minor ginsenosides in Lactobacillus fermentum KP-3-fermented ginseng for mice fed a high fat diet
    Food Funct. (IF 3.289) Pub Date : 2018-10-10
    Bo Nan, Yan Long Liu, Ying You, Wan Cong Li, Jing Jing Fan, Yu Shan Wang, Chun Hong Piao, Dong Liang Hu, Gui Jiao Lu, Yuhua Wang

    Lactobacillus fermentum KP-3 was isolated from Korean pickle and used to ferment ginseng. The changes in the minor ginsenosides in the fermented ginseng were analyzed and the material was evaluated in high fat diet-induced mice. Total ginsenosides increased from 0.746 mg/g to 0.939 mg/g after fermentation, and the levels of minor ginsenosides (Rg2, Rg3, Rh1, Rh2, F2, and Ro) increased from 0.186 mg/g to 0.704 mg/g. In animal study, the serum TC and LDL levels in the HFD group were significantly higher than those of the control group. Compared with the HFD group, the probiotic-fermented ginseng significantly decreased serum TC and LDL levels. In addition, serum and liver ALT and AST levels were dramatically increased in the HFD group, but these increases were significantly inhibited by treatment with the probiotic-fermented ginseng. Furthermore, fermented ginseng reduced high fat diet-induced liver lipid accumulation. Overall, fermentation with L. fermentum KP-3 enhanced minor ginsenosides in ginseng and this probiotic-fermented ginseng ameliorated hyperlipidemia and liver injury induced by high fat diet.

    更新日期:2018-10-10
  • The Protective Effects of Selenium-Enriched Spirulina on the Reproductive System of Male Zebrafish (Danio rerio) Exposed to Beta-Cypermethrin
    Food Funct. (IF 3.289) Pub Date : 2018-10-10
    Yi Zhang, Yuhang Zhou, Qingyang Tang, Feng Hu, Lixue Feng, Jinglian Shen, Bei Huang

    Beta-cypermethrin (beta-CYP), which is widely used for the control of indoor and field pests, is a highly lipophilic insecticide with environmental estrogenic effects. Selenium-enriched Spirulina (Se-SP) is a novel natural antioxidant agent with high nutritive value. This study aimed to investigate the protective effects of Se-SP on the reproductive system of male zebrafish (Danio rerio) exposed to beta-CYP. We determined the protective effect of Se-SP on male zebrafish exposed to 7 nmol/L beta-CYP by measuring the activity of sperm and antioxidants, examining tissue sections, measuring hormone secretion levels, and analyzing the expression of related proteins and genes during spermatogenesis. We found that beta-CYP enhanced VTG synthesis and estrogen (E2) secretion, increased the number of spermatogonia and spermatocytes, and decreased the number of spermatids and Sertoli cells. However, treatment of 50 mg/L Se-SP (Se:25 μmol/g Se-SP) almost completely ameliorated the deleterious effects of beta-CYP. The protective mechanism of Se-SP in the testes of beta-CYP-treated fish involved enhanced of antioxidant enzyme activity and increased androgen secretion by downregulation of the expression of cyp19a, nanos2, piwil1, dazl and sycp3, and upregulation of the expression of odf3b, igf3 and dmrt1, which affected the testosterone production and spermatogenesis. Our study strongly indicates that treatment with Se-SP can effectively prevent the oxidative damage to the reproductive system during spermatocytes differentiation induced by beta-CYP exposure.

    更新日期:2018-10-10
  • Metabonomics analysis of quercetin against the nephrotoxicity of acrylamide in rat
    Food Funct. (IF 3.289) Pub Date : 2018-10-10
    Lu Bo, Yanli Liu, Siqi Jia, Yajing Liu, Meiyan zhang, Siqi Li, Xiujuan Zhao, Changhao Sun

    This research aimed to analyse the protective effect of quercetin against the nephrotoxicity of acrylamide (AA) using metabonomics technology. Rats were randomly divided into six groups, including the control group, AA-treated group (5 mg/kg.bw/d), two dosages of quercetin-treated groups (10 and 50 mg/kg.bw/d) and two dosages of quercetin plus AA-treated groups. Quercetin and AA were administered to rats daily via gavage and drinking water, respectively. After a 16 week treatment, kidneys were collected for metabonomics analysis. A total of 14 metabolites were identified in positive and negative modes via the metabonomics profiles of kidney tissues. Compared with the control group, the intensities of uric acid, 6,8-dihydroxypurine, hypoxanthine, guanosine, L-phenylalanine, succinyladenosine, tryptophan, lysophosphatidylcholines (LPC(16:0), LPC(18:1(9z)), LPC(18:2(9z,12z))) and inosine in the AA-treated group were significantly increased (p < 0.01); and the intensities of L-acetylcarnitine, 2-phenylacetamide and pantothenic acid in the AA-treated group were decreased (p < 0.01). However, the intensities of the previously mentioned metabolites had the opposite trends in the high-dose quercetin (50 mg/kg.bw/d) plus AA-treated group (p < 0.01 or p < 0.05). Results showed that quercetin exerted protective effects on AA-induced nephrotoxicity by enhancing the antioxidant defence system of the body and regulating phospholipid, energy and amino acid metabolism.

    更新日期:2018-10-10
  • In Vitro Fermentation of Raffinose by the Human Gut Bacteria
    Food Funct. (IF 3.289) Pub Date : 2018-10-10
    Bingyong Mao, Hongyu Tang, Jiayu Gu, Dongyao Li, Shumao Cui, Jianxin Zhao, Hao Zhang, Wei Chen

    Raffinose has become a major focus of research interest and recent studies have shown that besides beneficial bifidobacteria and lactobacilli, Escherichia coli, Enterococcus faecium and Streptococcus pneumoniae can also utilize raffinose and raffinose might lead to flatulence in some hosts. Therefore, it is required to find out the raffinose-metabolizing bacteria in the gut and the bacteria responsible for the flatulence. BLASTP search results showed that homologous proteins of glycosidases related to raffinose utilization are widely distributed in 196 of the 528 gut bacterial strains. Fifty-nine bacterial strains belonging to nine species of five genera were isolated from human feces and were found to be capable of utilizing raffinose; of these species, Enterococcus avium and Streptococcus salivarius were reported for the first time. High-performance liquid chromatography (HPLC) analysis of the supernatants of the nine species revealed that the bacteria could utilize raffinose in different manners. Glucose and melibiose were detected in the supernatants of Enterococcus avium E5 and Streptococcus salivarius B5, respectively. However, no resulting saccharides of raffinose degradation were detected in the supernatants of other seven strains, indicating that they had different raffinose utilization types from Enterococcus avium E5 and Streptococcus salivarius B5. Gas was produced with raffinose utilization by Escherichia coli, Enterococcus faecium, Streptococcus macedonicus, Streptococcus pasteurianus and Enterococcus avium. Thus, more attention should be paid to the raffinose-utilizing bacteria besides bifidobacteria and further studies are required to reveal the mechanisms of raffinose utilization to clarify the relationship between raffinose and gut bacteria.

    更新日期:2018-10-10
  • Preventive mechanism of bioactive dietary foods on obesity-related inflammation and diseases
    Food Funct. (IF 3.289) Pub Date : 2018-10-10
    Jeehye Sung, Chi-Tang Ho, Yu Wang

    Obesity is associated with low-grade chronic inflammation of adipose tissue, which leads to the development of metabolic disorders such as insulin resistance, type 2 diabetes, cardio vascular disease (CVD), and cancer. Obesity and a high calorie diet are associated with altered endocrine and metabolic functions of adipose tissue contributing to systemic inflammation as a result of the release of pro-inflammatory cytokines/adipokines into the circulation and metabolic endotoxemia. Furthermore, the accumulation of proinflammatory macrophages within the visceral adipose tissue also may be a major cause of chronic inflammation of adipocytes. Thus, it is important to understand factors that regulate the function of both adipocytes and macrophages to find attractive strategies that counteract the burden of obesity-induced health problems. Although the vast range of activities of dietary bioactive compounds on obesity and inflammation has been widely investigated, the mechanism underlying their beneficial effects on obesity-associated inflammatory response are still poorly understood. This review focuses on the molecular biological mechanism of obesity-induced inflammation and the reciprocal interactions between the major molecular mechanisms and a range of dietary bioactive compounds.

    更新日期:2018-10-10
  • Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men
    Food Funct. (IF 3.289) Pub Date : 2018-10-08
    Ying Zhang, Jin Liu, Xiao-qiang Chen, C.-Y. Oliver Chen
    更新日期:2018-10-10
  • Saponins from Boussingaultia gracilis prevent obesity and related metabolic impairments in diet-induced obese mice
    Food Funct. (IF 3.289) Pub Date : 2018-09-28
    Lei Liu, Ningning Wang, Yanan Ma, Yang Liu, Deliang Wen
    更新日期:2018-10-10
  • Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil
    Food Funct. (IF 3.289) Pub Date : 2018-09-18
    Renato André Zan, Ângela Fernandes, Stephanie Jedoz, Taofiq Oludemi, Ricardo C. Calhelha, Tânia C. S. P. Pires, Maria José Alves, Roberto Carlos Campos Martins, Lillian Barros, Isabel C. F. R. Ferreira
    更新日期:2018-10-10
  • Isofraxidin targets the TLR4/MD-2 axis to prevent osteoarthritis development
    Food Funct. (IF 3.289) Pub Date : 2018-09-24
    Jialei Jin, Xingfang Yu, Zhichao Hu, Shangkun Tang, Xinyang Zhong, Jianchen Xu, Ping Shang, Yixing Huang, Haixiao Liu
    更新日期:2018-10-10
  • Nutritional characterization and shelf-life of packaged microgreens
    Food Funct. (IF 3.289) Pub Date : 2018-10-09
    Vito Michele Paradiso, Maria Castellino, Massimiliano Renna, Concetta Eliana Gattullo, Maria Calasso, Roberto Terzano, Ignazio Allegretta, Beniamino Leoni, Francesco Caponio, Pietro Santamaria
    更新日期:2018-10-09
  • An additional data fusion strategy for the discrimination of porcini mushrooms from different species and origins in combination with four mathematical algorithms
    Food Funct. (IF 3.289) Pub Date : 2018-10-09
    LuMing Qi, Jieqing Li, Honggao Liu, Tao Li, Yuanzhong Wang

    Porcini are a source of popular food products with many beneficial functions and the internal quality of these mushrooms is largely determined by many factors. An additional data fusion strategy based on low-level data fusion for two portions (cap and stipe) and mid-level data fusion for two spectroscopic techniques (UV and FTIR) was developed to discriminate porcini mushrooms from different species and origins. Based on a finally obtained data array, four mathematical algorithms including PLS-DA, k-NN, SVM and RF were comparatively applied to build classification models. Each calibrated model was developed after selecting the best debug parameters and then a test set was used to validate the established model. Results showed that SVM algorithm based on a GA procedure searching for parameters had the best performance for discriminating different porcini samples with the highest cross-validation, specificity, sensitivity and accuracy of 100.00%. Our study proved the feasibility of two spectroscopic techniques for the discrimination of porcini mushrooms originated from different species and origins. This proposed method can be used as an alternative strategy for the quality detection of porcini mushrooms.

    更新日期:2018-10-09
  • Protection of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism
    Food Funct. (IF 3.289) Pub Date : 2018-10-08
    Xiaofei Liu, Xiuting Yu, Xiaofei Xu, Xiaojun Zhang, Xuewu Zhang

    In this study, the protective effects of a carboxymethyl polysaccharide CMP33 from Poria cocos against inflammatory bowel disease (IBD) were investigated using TNBS-induced colitis in mice. The results showed that CMP33 markedly ameliorated the colitis severity, including 2-fold decrease in the mortality rate, 50% decrease in disease activity index, 36%-44% decrease in macro- or microscopic histopathologic score, compared with TNBS administration. Moreover, CMP33 decreased the levels of pro-inflammatory cytokines and increased the levels of anti-inflammatory cytokines in colon tissue and serum of colitis mice. Using iTRAQ-coupled- nano-HPLC-MS/MS-based proteomics, the proteins profiles after TNBS, high-or low-dose CMP33 and drug Salazosulfapyridine (SASP) treatments were compared and many differentially expressed proteins were identified. Among them, 7 proteins (Hmgcs2, Fabp2, Hp, B4galnt2, B3gnt6, Sap and Ca1) were proposed to be the common targeting protein group (TPG) of CMP33 and drug SASP. Especially, some targeting proteins were CMP33-dose-specific: high-dose-specific TPG (Mtco3, Gal-6, Mptx, S100g and Hpx) and low-dose-specific TPG (Zg16, Hexb, Insl5, Cept1, Hspb6 and Ifi27l2b), suggesting the complex acting mechanism of CMP33. GC-TOF-MS-based metabolomics revealed that oleic acid and dihydrotestosterone could be the common targets of CMP33 and SASP. By integrative analysis of proteomics and metabolomics, key proteins-metabolites pathways (PMP) were identified, PMP for high-dose: 2-Hydroxybutyric acid – (GPT, GGH) – Glutathione – ALB –Testosterone –TTR–Dihydrotestosterone; PMP for low-dose: (PYY, FABP2, HMGCS2)–Oleic acid–TTR– Dihydrotestosterone. Totally, these results demonstrated the protective effect of CMP33 against IBD in mice through potential TPG and PMP.

    更新日期:2018-10-09
  • A 6-weeks supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome markers
    Food Funct. (IF 3.289) Pub Date : 2018-10-08
    Daniel Martínez-Maqueda, Belén Zapatera, Angélica Gallego-Narbón, Pilar Vaquero, Fulgencio Saura-Calixto, Jara Pérez-Jiménez

    Grape polyphenols have shown a promising role in the modulation of metabolic syndrome (MetS), mostly in animal models. However, clinical studies are scarce and they usually only consider a fraction of polyphenols, ignoring the non-extractable polyphenols (high molecular weight compounds or associated with macromolecules such as dietary fibre). This study aimed to evaluate the effect of grape pomace, rich in both extractable and non-extractable polyphenols, on markers of MetS. Fifty subjects (22 women) aged 20-65 with at least two MetS factors were randomly assigned to the product (daily dose of 8 g of dried grape pomace) or to the control group in a 6 weeks crossover design with a 4 weeks wash-out. Samples were collected at the beginning and at the end of both periods; half of the participants were subjected to an Oral Glucose Tolerance Test at the beginning and the end of the supplementation period. Grape pomace supplementation significantly improved fasting insulineamia (p<0.01), without affecting other cardiometabolic risk parameters. A tendency towards an improvement in postprandial insulineamia was observed, particularly in those subjects with higher fasting insulin levels. Therefore, supplementation with grape pomace may be a strategy for improving insulin sensitivity in subjects at high cardiometabolic risk.

    更新日期:2018-10-09
  • The solvation properties and effect of D-fructose on taste behavior of Citrus aurantium active components in aqueous solutions
    Food Funct. (IF 3.289) Pub Date : 2018-10-08
    Milan Vraneš, Jovana Panić, Aleksandar Tot, Snezana Papovic, S Ostojic , Slobodan Gadzuric

    The densities and viscosities of synephrine hydrochloride and octopamine hydrochloride aqueous solutions were determined. Apparent molar volumes, apparent molar volume at infinite dilution, viscosity B-coefficients and hydration number were calculated, and it was found that synephrine hydrochloride acts as better structure maker than octopamine hydrochloride in aqueous solutions. Densities of investigated salts were measured in aqueous D-fructose solutions, and corresponding apparent molar volumes of transfer at infinite dilution was determined. Its taste behavior was discussed based on calculated values for apparent specific volume and intrinsic viscosity. Molecular dynamics simulations and radial distribution functions were applied in order to understand nature of interactions and water structuring in studied systems. Change in taste behavior was observed with increasing concentration of cosolute, and it was found that addition of sugar increases the bitterness of solution. From molecular docking study on bitter receptor TAS2R38, strongest interactions for synephrine-HCl was noted causing most bitter taste.

    更新日期:2018-10-08
  • A colon-specific delivery system for quercetin with enhanced cancer prevention based on co-axial electrospinning
    Food Funct. (IF 3.289) Pub Date : 2018-10-08
    Peng Wen, Teng-Gen Hu, Lin Li, Min-Hua Zong, Hong Wu

    The antioxidant quercetin (Q) is a bioactive compound that can inhibit the colon cancer. However, the poor stability in the upper gastro-intestine tract and low bioavailability of Q compromised its benefits. In this study, a biopolymer-based colon-specific delivery system for Q was constructed by co-axial electrospinning. The quercetin-loaded chitosan nanoparticles (QCNP) were firstly prepared and characterized. Then, Q-loaded electrospun fiber mat (Q-loaded EFM) containing prebiotics (galactooligosaccharide, GOS)) were fabricated using sodium alginate as shell layer and the above QCNP and prebiotics as core layer. DPPH assay showed that the antioxidant activity of Q was maintained in the obtained film. Owing to the addition of prebiotics GOS, the obtained fiber mat possessed good prebiotic effects. In vitro release kinetics showed a sustained and targeted colon-specific release of Q from the Q-loaded EFM containing GOS, and the release rate of Q was enhanced by the presence of GOS. The obtained film also exhibited inhibition effects on Caco-2 cells in a dose- and time-dependent manner. Flow cytometry and fluorescence microscopy analysis indicated that Q-loaded EFM containing GOS exerted its activity on colonic cancer cells by arresting cell cycle on G0/G1 phase and triggering apoptotic cell death. This study demonstrates the potential of obtained film as oral delivery system for encapsulation, protection, and release of Q at colon for the oral therapy of colon disorders.

    更新日期:2018-10-08
  • Bioactive compounds, pharmacological and food application of Syzygium cumini- a review
    Food Funct. (IF 3.289) Pub Date : 2018-10-08
    Navnidhi Chhikara, Ravinder Kaur, Sundeep Jaglan, Paras Sharma, Yogesh Gat, Anil Panghal

    The present review explores the nutritional, phytochemical and pharmacological potential as well as diverse food usage of Syzygium cumini. S. cumini is a traditional medicinal plant with various bioactive compounds distributed in all parts of the plant. The major bioactive compounds present in the edible part are myricetin, oxalic acid, gallic acid, citronellol, cyaniding diglycoside, hotrienol, phytosterols, flavonoids, carotenoids and polyphenols as well as micronutrients accounting for numerous health benefits. The potential benefits of these bioactive compounds are to prevent/reduce metabolic abnormalities and various diseases. The health protective effects and functional properties of the plant are proven by different in-vitro and vivo pharmacological studies. All parts of the plant have good health benefits like hypoglycemic, anti-inflammatory, antianemic, antibacterial, antioxidant, antiallergic, hepatoprotective, hypolipidemic and antipyretic properties. The fruit of S. cumini can be consumed raw or processed in the form of jam, jellies, wine, fermented beverages and many other value added food products.

    更新日期:2018-10-08
  • 更新日期:2018-10-08
  • High Dietary Inflammatory Index scores are associated with elevated risk of hepatocellular carcinoma in a Case-Control Study
    Food Funct. (IF 3.289) Pub Date : 2018-10-05
    Xiao-Yan Wang, Ai-ping Fang, Pei-Yan Chen, Gong-Cheng Liao, Yao-Jun Zhang, Nitin Shivappa, James R. Hébert, Yu M. Chen, H. L. Zhu

    Chronic inflammation and diet play crucial roles in the development of hepatocellular carcinoma (HCC); yet the association between dietary inflammatory potential and risk of HCC has rarely been investigated. This study aimed to examine whether a higher dietary inflammatory index (DII®) score (indicating a pro-inflammatory diet) is associated with an increased risk of HCC in a matched case-control study conducted between September 2013 and October 2017 in South China. A total of 659 cases with newly diagnosed, previously untreated HCC and 659 controls individually matched on age (±3 years) and sex were included in this study. DII scores were computed based on dietary intake collected via a validated 79-item food frequency questionnaire (FFQ) during the one year prior to diagnosis (for cases) or interview (for controls). Logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (CI) between DII score and risk of HCC, adjusted for age, energy intake, body mass index, physical activity, marital status, education, household income, smoking status, and hepatitis B virus (HBV) infection status. Compared with subjects in the lowest DII tertile, subjects in the highest tertile had an elevated risk of HCC (fully adjusted OR: 3.22, 95% CI: 1.30-7.98, P-trend=0.009). In stratified analyses, a significantly positive association was observed only in men, individuals with lower education level, smokers and non-alcohol drinkers. In conclusion, a higher DII score, representing a more inflammatory diet, was associated with an increased risk of HCC, in men, individuals with lower education level, smokers and non-alcohol drinkers.

    更新日期:2018-10-05
  • Characterization of pepsin from rabbit gastric extract, its action on β-casein and the effects of lipids on proteolysis
    Food Funct. (IF 3.289) Pub Date : 2018-10-04
    Laura Sams, Sawsan Amara, Pascal Mansuelle, Remy Puppo, Régine Lebrun, Julie Paume, Jacqueline Giallo, Frédéric Carrière

    Rabbit gastric extracts (RGE) is a source of gastric enzymes for in vitro digestion studies. While its gastric lipase activity has been characterized and compared to other lipases, its pepsin activity has not been studied. We measured pepsin activity in RGE using both hemoglobin and azocoll a substrates, and identified the protein separated by SDS-PAGE as a type II-4 mature pepsin of 328 amino acid residues using Edman sequencing, LC-MS/MS analysis and intact mass measurement. As a proof of concept that RGE was suitable for in vitro digestion of both proteins and lipids, it was used for studying the proteolysis of β-casein under conditions mimicking the early stages of intragastric digestion. β-casein was presented either in solution or at the surface of a β-casein-stabilized rapeseed oil emulsion to investigate the impact of lipids and lipolysis on proteolysis. Proteolysis of β-casein was quantified based on the kinetics of β-casein disappearance, the identification of various peptides generated upon digestion and their variation with time. The results obtained with RGE were highly similar to those obtained with equivalent amounts of porcine pepsin used a reference standard. Digestion of β-casein was slower when it was presented at the oil-water interface and some degradation peptides were transiently observed at higher levels and for a longer time than with β-casein in solution, or accumulated upon digestion. N-terminal sequencing of the main isolated peptides revealed a sequential action of pepsin starting from the hydrophobic C-terminal end of β-casein and which was impaired by β-casein interaction with lipids.

    更新日期:2018-10-05
  • Inhibition by microbial metabolites of Chinese dark tea of age-related neurodegenerative disorders in senescence-accelerated mouse prone 8 (SAMP8) mice
    Food Funct. (IF 3.289) Pub Date : 2018-09-26
    Shuxian Cai, Heng Yang, Beibei Wen, Kun Zhu, Xin Zheng, Jianan Huang, Yingzi Wang, Zhonghua Liu, Pengfei Tu
    更新日期:2018-10-04
  • Impact of composition and texture of protein-added yogurts on oral activity
    Food Funct. (IF 3.289) Pub Date : 2018-09-24
    Pere Morell, Amparo Tárrega, Edward Allen Foegeding, Susana Fiszman
    更新日期:2018-10-04
  • Effects of different methionine level on offspring piglets during late gestation and lactation
    Food Funct. (IF 3.289) Pub Date : 2018-10-04
    Md. Abul Kalam Azad, Peng Bin, Gang Liu, Jun Fang, Tiejun Li, Yulong Yin

    Maternal dietary supplementation during gestation and lactation improves the health of piglets. The purpose of this study was to determine the effect on piglets of different levels of methionine (Met) supplementation in the sows’ diet during late gestation and lactation. Thirty sows were randomly divided into three groups and fed the following diets from day 90 of gestation to day 21 of lactation: (a) control group (basal diet containing 0.36% Met), (b) 0.48% Met group (basal diet with additional 0.12% Met), and (c) 0.60% Met group (basal diet with additional 0.24% Met). On day 21 after farrowing, piglets of average body weight (n = 10 per group) were selected for sample collection. The results showed that the 0.48% Met and 0.60% Met diets significantly lowered the malondialdehyde content in the piglets’ serum (P < 0.05). In addition, glutathione peroxidase content was significantly increased in the 0.48% Met group (P < 0.05) and the total glutathione content was significantly reduced in the 0.60% Met group (P < 0.05) compared to the control group. Furthermore, Met supplementation of the sows’ diet was associated with alterations in 37 plasma metabolites in the piglets. In the piglets’ intestinal microbiota, the relative abundances of Phascolarctobacterium and Bacteroidetes in the 0.48% Met group were higher than in the other two groups (P < 0.05). Our results suggest that a diet including 0.48% Met during late gestation and lactation can maintain the health of piglets by increasing antioxidant capacity and changing the intestinal microbiota composition, but a higher level of Met supplementation may increase the potential risk to piglets.

    更新日期:2018-10-04
  • Transcriptome analysis reveals the mechanism of the effect of flower tea Coreopsis tinctoria on hepatic insulin resistance
    Food Funct. (IF 3.289) Pub Date : 2018-10-04
    Baoping Jiang, Qiuyue Lv, Wenting Wan, Keping Hu, Liang Le, Li-jia Xu, Pei-Gen Xiao

    Non-Camellia tea and herbal medicine help prevent the development of diabetes and other metabolic diseases. Previous studies found that Coreopsis tinctoria (CT) flower tea increases insulin sensitivity and, in some high-fat diet (HFD)-fed rats, even prevents hepatic metabolic disorders. However, the molecular mechanisms by which CT improves insulin resistance are unknown. In this study, six-week-old rats were fed a normal diet (ND), HFD or HFD supplemented with CT for 8 weeks. Serum samples were collected, and the liver was extracted for RNA-seq gene expression analysis. Real-time PCR and Western blotting further verified the RNA-seq results. In our results, dietary CT ameliorated HFD-induced hepatosteatosis, glucose intolerance, and insulin resistance. In the HFD group, 1667 differentially expressed genes (DEGs) were identified compared with the ND group. In the CT group, 327 DEGs were identified compared with the HFD group. Some of these DEGs were related to insulin signalling, hepatic lipogenesis and glucose homeostasis. This study suggested that insulin resistance with hyperinsulinaemia, not insulin insufficiency, is an early problem in HFD-fed rats, and CT downregulates insulin secretion genes (e.g., Rasd1, Stxbp1 and Sfxn1). Hepatic gene and protein expression analyses indicated that the regulatory effects of CT on glucose and lipid homeostasis are likely mediated via the Akt/FoxO1 signalling pathway and regulated by the transcription factors HES1 and SHP. Our study provides transcriptomic evidence of the complex pathogenic mechanism involved in hepatic insulin resistance and that supplementation with CT improves insulin resistance at a global scale.

    更新日期:2018-10-04
  • 更新日期:2018-10-03
  • Screening of ordinary commercial varieties of apple fruits under different storage conditions for their potential vascular and metabolic protective properties
    Food Funct. (IF 3.289) Pub Date : 2018-10-03
    RAFFAELLA SOLETI, Gregory Hilairet, Patricia Mallegol, Catherine Dourgia, Mehdi Frifra, Marie Charlotte Guillou, Agnes Gacel, Sylvain Guyot, Pascale Pignon, Laetitia Basset, Yves Cadot, Jean Pierre Renou, Mathilde Orsel, Ramaroson Andriantsitohaina

    Epidemiological studies reported that apple consumption was associated to a decrease of cardiovascular and metabolic dysfunction, probably due to the polyphenols and fibers contained in this fruit. Storage conditions and genetic origin of apples have been reported to influence their content and, as a consequence, their pharmacological properties. Present study evaluated the influence of varieties and storage conditions of traditional and highly appreciated apples including Gala, Golden Delicious, Granny Smith and Pink Lady varieties after harvest and stored in classic cold conditions, under controlled atmosphere, or extreme ultra-low oxygen conditions. Thus, a multi-parametric screening on cell models associated to vascular and metabolic dysfunctions - such as endothelial and smooth muscle cells, hepatocytes, adipocytes and macrophages - in relation to apple polyphenol content has been developed. This strategy demonstrated that, over all, peeled apple samples exhibited a vascular tropism and acted mainly on proliferation and oxidative stress on endothelial and smooth muscle cells. Apple extracts appeared to be less effective on adipocytes and macrophages, but they exhibited antioxidant properties in hepatocytes. Among the varieties, Gala and Golden Delicious were the most efficient against the processes involved in the development of atherosclerosis. Concerning storage condition, most of the apple varieties were more efficient under harvest condition; while they could not can be discriminated neither under all other cold conditions nor the concentration used except for the Gala samples. Interestingly, pharmacological properties were associated with polyphenol profiles of freeze dried flesh apple powder. The present report revealed the potential use of some apple extracts as effective food supplements or nutraceuticals for the prevention and/or management of cardiovascular and metabolic diseases.

    更新日期:2018-10-03
  • Leveraging plant exine capsules as pH-responsive delivery vehicles for hydrophobic nutraceutical encapsulation
    Food Funct. (IF 3.289) Pub Date : 2018-09-21
    Di Wu, Youyan Liang, Kai Huang, Xinyi Jing, Bin Li, Hongshan Liang
    更新日期:2018-10-03
  • Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash
    Food Funct. (IF 3.289) Pub Date : 2018-09-18
    Marija Smiljković, Maria Inês Dias, Dejan Stojković, Lillian Barros, Danka Bukvički, Isabel C. F. R. Ferreira, Marina Soković
    更新日期:2018-10-03
  • Microbiota-accessible pectic poly- and oligosaccharides in gut health
    Food Funct. (IF 3.289) Pub Date : 2018-09-18
    Jagan Mohan Rao Tingirikari
    更新日期:2018-10-03
  • Total and sn-2 fatty acids profile of breast milk from women delivering preterm infants under the influence of maternal characteristics
    Food Funct. (IF 3.289) Pub Date : 2018-10-02
    Yahua Xu, Ce Qi, renqiang yu, Xiangyu Wang, qin zhou, Jin Sun, Qingzhe Jin, Xingguo Wang

    Breast milk is the gold standard for infant formula. However, in current formulas, the fatty acids (FAs) composition differs from that in breast milk from mothers giving birth to preterm infants. The aim of this study was to determine the composition and positional distribution of FAs in milk triacylglycerol, and futher to investigate the effect of maternal backgrounds on FAs composition. Breast milk samples (4, 11, 30, 60, and 90 (all ± 3) days post-partum) were collected from 59 healthy women delivering preterm infants. Total and sn-2 milk FAs composition was determined using gas chromatography. Multivariate statistical analysis showed significant differences in FAs profiles of milk with different lactation time, gestational age, pre-pregnancy body mass index (BMI), and maternal age. Linoleic and linolenic acid were much higher whereas docosahexaenoic (DHA) and arachidonic acid were lower in preterm milk from Wuxi district than that from America and Europe. Higher pre-pregnancy BMI resulted in lower sn-2 DHA and linoleic acid (LA) in colostrum. Finally, sn-2 polyunsaturated FAs was lower in preterm colostrum from women aged over 30 years. Overall, these results suggest that European and American standards of preterm formula may be not suitable for Chinese preterm infants, maternal pre-pregnancy BMI should be maintained below 24 to ensure optimal DHA and LA content in colostrum, and polyunsaturated FAs fortification in the maternal diet or preterm formula is needed for women with advanced age.

    更新日期:2018-10-03
  • Understanding the role of extracts from sea buckthorn seed residues in anti-melanogenesis properties on B16F10 melanoma cells
    Food Funct. (IF 3.289) Pub Date : 2018-09-24
    Jiachan Zhang, Changtao Wang, Chengtao Wang, Baoguo Sun, Cai Qi
    更新日期:2018-10-02
  • Peracetylation as strategy to improve oleuropein stability and affinity to fatty foods.
    Food Funct. (IF 3.289) Pub Date : 2018-10-01
    Sonia Bonacci, Rosina Paonessa, Paola Costanzo, Raffaele Salerno, Jessica Maiuolo, Monica Nardi, Antonio Procopio, Oliverio Manuela

    The biological activities of oleuropein (Ole) and its metabolites have extensively been documented and shown a spectrum of highly interesting bioactivities which prove the potential of oleuropein for inclusion into food and beverages. In the present work, acetylated oleuropein (OleAc), a safe, biologically active semi-synthetic stable derivative of oleuropein, has been proposed as an easy alternative to make oleuropein more bioavailable and suitable to be added to fatty foods. . Extra virgin olive oil (EVOO) has been proposed as a model of perishable food to evaluate the potential application of OleAc for the preparation of functional food and the impact of the formulation factors on fragile nutritive components of EVOO. Both classical and ultrasounds (US) assisted enrichment procedures have been tested and the evaluation of the effects on oil stability across time has been presented. Moreover, LC-MS analyses of hydrophilic extract of target oils have been used to verify the stability of acetylation of oleuropein across time after enrichment. Finally, a preliminary sensorial analysis has been performed in order to understand if such enrichment could origin some oil taste modification. The present results are intended as a preliminary support to a possible requirement of Novel Food status of OleAc.

    更新日期:2018-10-01
  • Dual action of vitamin C in iron supplement therapeutics for iron deficiency anemia: prevention of liver damage induced by iron overload
    Food Funct. (IF 3.289) Pub Date : 2018-09-18
    Huan He, Yang Qiao, Zeyu Zhang, Zelong Wu, Dan Liu, Zhangping Liao, Dong Yin, Ming He
    更新日期:2018-10-01
  • In vitro human bioavailability of major, trace and ultra-trace elements in Chilean ‘natural’ wines from Itata Valley
    Food Funct. (IF 3.289) Pub Date : 2018-09-10
    Mónica Latorre, Carlos Peña-Farfal, Yamil Neira, Paloma Herbello-Hermelo, Raquel Domínguez-González, Pilar Bermejo-Barrera, Antonio Moreda-Piñeiro
    更新日期:2018-10-01
  • Impact of short-term flavanol supplementation on fasting plasma trimethylamine N-oxide concentrations in obese adults
    Food Funct. (IF 3.289) Pub Date : 2018-09-25
    Chris J. Angiletta, Laura E. Griffin, Cortney N. Steele, David J. Baer, Janet A. Novotny, Kevin P. Davy, Andrew P. Neilson
    更新日期:2018-09-28
  • 更新日期:2018-09-28
  • A fucoidan from sea cucumber Pearsonothuria graeffei with well-repeated structure alleviates gut microbiota dysbiosis and metabolic syndromes in HFD-fed mice
    Food Funct. (IF 3.289) Pub Date : 2018-09-04
    Shan Li, Junhui Li, Guizhu Mao, Tiantian Wu, Yaqin Hu, Xingqian Ye, Ding Tian, Robert J. Linhardt, Shiguo Chen
    更新日期:2018-09-28
  • Troxerutin subdues hepatic tumorigenesis via disrupting the MDM2–p53 interaction
    Food Funct. (IF 3.289) Pub Date : 2018-09-27
    Nisha Susan Thomas, Kiran George, Athavan Alias Anand Selvam
    更新日期:2018-09-27
  • Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation
    Food Funct. (IF 3.289) Pub Date : 2018-09-06
    Peng Yang, Guo-Bin Ding, Wen Liu, Rong Fu, Amin Sajid, Zhuoyu Li
    更新日期:2018-09-27
  • 更新日期:2018-09-27
  • The redox balance of healthy Brazilian adults is associated with GPX1 Pro198Leu and -602A/G polymorphisms, selenium status, and anthropometric and lifestyle parameters
    Food Funct. (IF 3.289) Pub Date : 2018-09-14
    Kaluce G. S. Almondes, Barbara R. Cardoso, Cristiane Cominetti, Nadir N. Nogueira, Dilina N. Marreiro, Tiago F. Oliveira, Ana P. M. Loureiro, Silvia M. F. Cozzolino
    更新日期:2018-09-27
  • Screening for active constituents in Turkish galls against ulcerative colitis by mass spectrometry guided preparative chromatography strategy: in silico, in vitro and in vivo study
    Food Funct. (IF 3.289) Pub Date : 2018-09-12
    Jie Zang, Shangzhi Ma, Cuizhe Wang, Gang Guo, Liangxue Zhou, Xing Tian, Mengying Lv, Jun Zhang, Bo Han
    更新日期:2018-09-27
  • Lacto-fermented sauerkraut improves symptoms in IBS patients independent of product pasteurisation – a pilot study
    Food Funct. (IF 3.289) Pub Date : 2018-09-03
    Elsa Sandberg Nielsen, Eirik Garnås, Kathrine Juul Jensen, Lars Hestbjerg Hansen, Peder Sandvold Olsen, Christian Ritz, Lukasz Krych, Dennis Sandris Nielsen
    更新日期:2018-09-27
  • Potential of iturin as functional agents: safe, prebiotic, and cytotoxic to cancer cells
    Food Funct. (IF 3.289) Pub Date : 2018-09-26
    Haobin Zhao, Junjun Li, Yawen Zhang, Shuzhen Lei, Xixi Zhao, Dongyan Shao, Chunmei Jiang, Jun ling Shi, Hui Sun

    Iturin produced by Bacillus subtilis was previously found to have significant antifungal activities, showing potential for application to food to protect from spoilage and decay. However, its safety must be evaluated before it can be used in foods consumed by mammals. Therefore, we carried out acute toxicity (7 days) and subacute toxicity (28 days) evaluations by intragastric administration of iturin at 5000 mg/kg (bw) and 2000 mg/kg (bw) to Kunming mice. At the end of the subacute toxicity evaluation, the blood parameters of the mice were evaluated, and the visceral organs and intestinal flora were examined. No acute toxicity was found for 5000 mg/kg (bw), and no significant negative effects were found for 2000mg/kg (bw) iturin for blood parameters or organ functions. A more important observation was that the application of iturin at the concentration of 2000 mg/kg (bw) showed great enhancement of the abundance of probiotics in the intestinal microflora. Iturin also showed inhibitory effects on cancer cells HepG2, Caco-2, MCF-7, A549, and BIU-87, at the level of 30 μM. The results indicate that B. subtilis iturin has the potential to be developed as a functional food additive with anticancer activity and the capability to enhance the abundance of probiotics in the intestinal microflora. This study indicates a new possible source of functional food additives.

    更新日期:2018-09-26
  • Coloured rice-derived polyphenols reduce lipid peroxidation and pro-inflammatory cytokines ex vivo
    Food Funct. (IF 3.289) Pub Date : 2018-09-20
    Esther T. Callcott, Kiara Thompson, Prakash Oli, Christopher L. Blanchard, Abishek B. Santhakumar
    更新日期:2018-09-26
  • 更新日期:2018-09-26
  • 更新日期:2018-09-26
  • Narrow-leafed lupin (Lupinus angustifolius L.) seed β-conglutins reverse the induced insulin resistance in pancreatic cells
    Food Funct. (IF 3.289) Pub Date : 2018-09-10
    Elena Lima-Cabello, Sonia Morales-Santana, Josefa León, Victor Alché, Alfonso Clemente, Juan D. Alché, Jose C. Jimenez-Lopez
    更新日期:2018-09-26
  • Interactions between acid and proteins under in vitro gastric condition – a theoretical and experimental quantification
    Food Funct. (IF 3.289) Pub Date : 2018-09-25
    Qi Luo, Wenting Zhan, Remko M. Boom, Anja E. M. Janssen
    更新日期:2018-09-25
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
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