Supramolecular hydrogels hold great promise for controlled drug delivery. Herein we report a supramolecular hydrogel based on a peptide bearing a terminal aldehyde. The hydrogel was prepared via an enzyme instructed self‐assembly (EISA) process, and the resulting hydrogels showed ultra‐stable properties in highly acidic or basic aqueous solutions. The hydrogelator could form Schiff bases with amine drugs. Owing to the pH‐responsive properties of Schiff bases, the hydrogels could be used for controlled release of encapsulated amine drugs. Our study provides a peptide‐based hydrogel that may be applied for controlled drug delivery.

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基于肽的超分子水凝胶可控制胺药物的递送

超分子水凝胶在控制药物输送方面具有广阔的前景。在本文中，我们报道了基于带有末端醛的肽的超分子水凝胶。水凝胶是通过酶指导自组装（EISA）过程制备的，所得水凝胶在高酸性或碱性水溶液中显示出超稳定的性能。水凝胶化剂可以与胺类药物形成席夫碱。由于席夫碱具有pH响应特性，因此水凝胶可用于控制释放的胶囊化胺类药物。我们的研究提供了一种可用于受控药物输送的基于肽的水凝胶。