The eco-compatible, base- and waste-free, energy-efficient, low-environmental-impact, gram-scale, mechanochemical preparation of marketed drugs such as nitrofurantoin (Furantin^©), dantrolene (Dantrium^©) and their structurally related derivatives is herein reported. Not a drop of organic solvent was used for the entire process and high yields of pure compounds were obtained without post-reaction work-up. Hydrazones were stable in the presence of water and gaseous HCl, formed as by-products during the synthesis. Comparative mechanochemical experiments were performed using diverse milling devices and jar materials, the active pharmaceutical ingredients were analyzed by PXRD and green metrics are calculated.

中文翻译：

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机械化学用于“无溶剂，无碱”制备基于乙内酰脲的活性药物成分：呋喃妥因和丹特罗

对市场上出售的药物（如呋喃妥因（Furantin ^©），丹特罗（Dantrium ^©）及其与结构相关的衍生物）进行生态兼容，无碱，无废物，节能，低环境影响，克级，机械化学制备的方法是在这里报道。在整个过程中不使用一滴有机溶剂，无需进行后反应后处理即可获得高产率的纯净化合物。dra在水和气态HCl的存在下是稳定的，在合成过程中会生成副产物。使用各种研磨设备和广口瓶材料进行了比较机械化学实验，通过PXRD分析了活性药物成分并计算了绿色标准。