Five new prenylated indole alkaloids, 17-hydroxynotoamide D (1), 17-O-ethylnotoamide M (2), 10-O-acetylsclerotiamide (3), 10-O-ethylsclerotiamide (4), and 10-O-ethylnotoamide R (5) were isolated from a co-culture of marine-derived fungi Aspergillus sulphureus KMM 4640 and Isaria felina KMM 4639. The structures of 1-5 were determined by detailed analysis of spectroscopic data and by comparison with related known compounds. The absolute configurations of 1-5 were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Compound 2 is able to inhibit the colony formation of human prostate cancer cells 22Rv1 at non-cytotoxic concentration of 10 μM.

中文翻译：

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来自海洋真菌的硫曲霉和费里亚草的共培养物中的炔丙基化吲哚生物碱。

五个新的炔丙基吲哚生物碱，17-羟基诺酰胺D（1），17-O-乙基诺酰胺M（2），10-O-乙酰硬脂酰胺（3），10-O-乙基硬酰胺（4）和10-O-乙基诺酰胺R（ 5）是从海洋来源的真菌硫化曲霉KMM 4640和Isaria felina KMM 4639的共培养物中分离得到的。1-5的结构是通过对光谱数据的详细分析并与相关的已知化合物进行比较来确定的。1-5的绝对构型由ECD光谱的时变密度泛函理论（TD-DFT）计算确定。化合物2能够以10μM的非细胞毒性浓度抑制人前列腺癌细胞22Rv1的集落形成。