Early life nutrition has long‐lasting influence in adults through key mediators that modulate epigenetic states, although the determinants involved that underlie this response remain controversial. Because of the similarities between metabolic, physiological, and endocrine changes and those occurring in human type 2 diabetes, we studied the interaction of diet during pregnancy regulating RNA adenosine methylation (N6‐methyladenosine [m6A]) and the transcriptome in Psammomys obesus.

中文翻译：

---

怀孕期间的饮食与后代下丘脑 RNA 甲基化和肥胖风险的调节有关

早期生命营养通过调节表观遗传状态的关键介质对成年人产生长期影响，尽管构成这种反应的决定因素仍然存在争议。由于代谢、生理和内分泌变化与人类 2 型糖尿病中发生的变化之间存在相似性，我们研究了妊娠期间饮食调节 RNA 腺苷甲基化（N6-甲基腺苷 [m6A]）和 Psammomys obesus转录组的相互作用。