Sargassum serratifolium has diverse health-promoting effects because of high levels of meroterpenoids with strong antioxidant and anti-inflammatory activities. Here, we investigated the effects of a meroterpenoid-rich fraction of an ethanolic extract of S. serratifolium (MES) on obesity and obesity-related hepatic steatosis in high fat (HF)-fed C57BL/6J mice. MES supplementation markedly reduced HF diet-induced obesity and hepatic steatosis without changes in food intake. MES improved blood lipid profile and elevated circulating adiponectin. Furthermore, MES notably increased uncoupling protein 1 (UCP-1)-positive cells and decreased macrophage infiltration in adipose tissue. MES exerted the anti-obesity and lipid-lowering effects by activating AMPK-related fatty acid oxidation signaling and inhibiting SREBP1c-related lipogenesis signaling in liver and adipose tissues. Our study indicates that MES prevents diet-induced obesity and related metabolic disorders at least partially by activating energy expenditure signaling and inhibiting lipogenesis. MES may be used as a pharmaceutical agent against obesity and related metabolic syndrome.

由于高含量的甲氧萜类化合物具有强大的抗氧化和抗炎活性，因此，羊栖藻具有多种促进健康的作用。在这里，我们调查了锯齿沙门氏菌乙醇提取物的富含甲蝶萜的馏分的作用。（MES）对高脂（HF）喂养的C57BL / 6J小鼠的肥胖及与肥胖相关的肝脂肪变性的研究。MES补充剂可显着减少HF饮食引起的肥胖症和肝脂肪变性，而无需改变食物摄入量。MES改善了血脂水平，升高了脂联素水平。此外，MES显着增加了解偶联蛋白1（UCP-1）阳性细胞，并减少了脂肪组织中巨噬细胞的浸润。MES通过激活AMPK相关的脂肪酸氧化信号并抑制SREBP1c相关的脂肪生成信号在肝脏和脂肪组织中发挥抗肥胖和降脂作用。我们的研究表明，MES至少可以通过激活能量消耗信号和抑制脂肪生成来预防饮食引起的肥胖症和相关的代谢紊乱。