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Aloe arborescens juice prevents EMF-induced oxidative stress and thus protects from pathophysiology in the male reproductive system in vitro
Environmental Research ( IF 8.3 ) Pub Date : 2018-06-07 , DOI: 10.1016/j.envres.2018.05.035
Przemyslaw Solek , Lena Majchrowicz , Marek Koziorowski

More and more studies suggest that prolonged exposure to EMF may cause adverse biological effects and point directly to a significantly negative correlation between EMF and human health, especially men fertility. In our previous study, we reported that this could be related to the EMF-induced reactive oxygen species formation, followed by DNA damage, cell cycle arrest and apoptosis induction. In this study, we decided to expand our research by the search for substances which would prevent EMF-induced damage in spermatogenic cells. Such an agent seems to be Aloe arborescens Mill. juice, which was shown to possess a wide range of protective properties. The administration of aloe extract helps among others to prevent the formation of free radicals by various biochemical pathways. Therefore, the main aim of our study was to provide a significant knowledge concerning the mechanism involved in the multi-pathway cytoprotective response of aloe juice against EMF. The study was carried out in an in vitro mouse spermatogenesis pathway cell lines (GC-1 spg and GC-2 spd). Our results suggest that the aloe juice has many positive effects, especially for the cellular antioxidant systems by reducing the intracellular reactive oxygen species pool induced by EMF. In consequence, aloe juice prevents DNA damage, cell cycle arrest and therefore the viability and metabolic activity of both cell line tested are preserved. In conclusion, our study provides new insight into the underlying mechanisms through which aloe juice prevents spermatogenic cells from cytotoxic and genotoxic events.



中文翻译:

芦荟汁可防止EMF诱导的氧化应激,从而在体外保护雄性生殖系统免受病理生理的影响

越来越多的研究表明,长时间暴露于EMF可能会导致不利的生物学影响,并直接表明EMF与人类健康(尤其是男性生育能力)之间存在显着的负相关性。在我们以前的研究中,我们报道这可能与EMF诱导的活性氧形成有关,随后与DNA损伤,细胞周期停滞和凋亡诱导有关。在这项研究中,我们决定通过寻找可以防止EMF诱导的生精细胞损害的物质来扩展我们的研究。这样的代理人似乎是芦荟。果汁,被证明具有广泛的防护性能。芦荟的管理提取物尤其有助于防止通过各种生化途径形成自由基。因此,我们研究的主要目的是提供有关芦荟汁对EMF的多途径细胞保护反应所涉及的机制的重要知识。该研究是在体外小鼠精子发生途径细胞系(GC-1 spg和GC-2 spd)中进行的。我们的结果表明,芦荟汁具有许多积极的作用,特别是通过减少EMF诱导的细胞内活性氧物种库,对细胞抗氧化系统具有积极作用。结果,芦荟果汁可防止DNA损伤,阻止细胞周期停滞,因此可以保留两种测试细胞系的活力和代谢活性。总之,我们的研究为芦荟汁阻止生精细胞发生细胞毒性和遗传毒性事件提供了新的思路。

更新日期:2018-06-07
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