The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery. In this report, we demonstrate that aromatic sulfonyl fluorides with a nitro group in their ortho position have remarkable antibacterial activity and are active against drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug resistant Acinetobacter baumannii, and Pseudomonas aeruginosa.

中文翻译：

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硝基磺酰氟是开发抗生素的新药效团†

开发针对革兰氏阴性菌的抗生素是药物发现的核心问题。在本报告中，我们证明在其邻位具有硝基的芳族磺酰氟具有显着的抗菌活性，并且对耐药病原体有活性，如耐甲氧西林金黄色葡萄球菌(MRSA)、多重耐药鲍曼不动杆菌和铜绿假单胞菌.