Ionizing radiation produces excessive reactive oxygen species (ROS) which impose detrimental effects on biological systems. Thus, it is important to explore clinically safe and efficacious radioprotection agents to scavenge ROS and reduce the risks of radiotherapy. Recently, emerging catalytic nanomaterials such as sulfide nanomaterials have shown capability of clearing ROS in vivo by unique electron transfers between atoms, but their catalytic activities are yet suboptimal. As such, there is an unmet need to improve catalytic properties for stronger antioxidant activities and radiation protection. Herein, we prepared ultrasmall Au-MoS₂ clusters (∼2.5 nm) and they showed enhanced catalytic properties via gold intercalation facilitating increased active sites and synergistic effects. Electrocatalysis results revealed that the catalytic activity of Au-MoS₂ towards H₂O₂ was superior to ultrasmall MoS₂ without Au. As a result, we found that improving the electrocatalytic property of Au-MoS₂ can effectively enhance corresponding antioxidant activities and radioprotection effects in vivo. In addition, Au-MoS₂ also showed significant radioprotection in vitro and dramatically reduced the excess of radiation-induced adverse ROS. It also rescued radiation-induced DNA damages and protected the bone marrow hematopoietic system from ionizing radiation.

电离辐射会产生过多的活性氧 (ROS)，这会对生物系统造成有害影响。因此，探索临床上安全有效的放射防护剂以清除ROS，降低放疗风险具有重要意义。最近，硫化物纳米材料等新兴催化纳米材料显示出通过原子间独特的电子转移清除体内活性氧的能力，但它们的催化活性仍不理想。因此，改善催化性能以获得更强的抗氧化活性和辐射防护的需求尚未得到满足。在此，我们制备了超小型 Au-MoS ₂簇（~2.5 nm），它们通过金嵌入显示出增强的催化性能，促进增加的活性位点和协同效应。电催化结果表明，Au-MoS ₂对H ₂ O ₂的催化活性优于不含Au的超小MoS _{2 。}结果，我们发现提高Au-MoS ₂的电催化性能可以有效增强相应的体内抗氧化活性和辐射防护作用。此外，Au-MoS ₂在体外也显示出显着的辐射防护作用，并显着降低了辐射引起的不良 ROS 的过量。它还可以挽救辐射引起的 DNA 损伤，并保护骨髓造血系统免受电离辐射。