There is debate in the literature as to whether inclusion of a placebo arm may alter characteristics of antidepressant trials. However, previous research has focused on response rates of various antidepressants on average only, ignoring potential differences among drugs or other aspects of trial findings. Little is known about the impact of a placebo arm on all-cause dropout and dropout due to adverse events.

中文翻译：

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安慰剂组对抗抑郁试验结果的影响：系统评价和Meta回归分析

关于是否包含安慰剂组可能会改变抗抑郁试验的特征，文献上存在争议。但是，先前的研究仅关注各种抗抑郁药的平均应答率，而忽略了药物之间或试验结果其他方面的潜在差异。关于安慰剂手臂对全因辍学和因不良事件而辍学的影响知之甚少。