Kinetic target-guided synthesis (KTGS) is a powerful strategy in which the biological target selects its own inhibitors by assembling them from biocompatible reagents via an irreversible process. In this approach, the biological target accelerates the reaction between complementary building blocks by bringing them in close proximity and proper orientation. KTGS has found application on various targets. Herein, we performed a druggability assessment for each target family reported in KTGS, calculated the pocket properties, and used them to extract possible discriminating factors for successful KTGS studies. A trend for less enclosed pockets emerged, but overall we conclude that the KTGS approach is universal and could be used without restrictions regarding the physicochemical properties of the addressed pocket.

中文翻译：

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动力学目标导向合成中使用的目标的可药性评估

动力学目标导向的合成（KTGS）是一种强大的策略，其中生物学目标通过不可逆的过程从生物相容性试剂中组装它们来选择自己的抑制剂。在这种方法中，生物靶标通过使互补构件彼此靠近并正确定向来加快它们之间的反应。KTGS已经在各种目标上得到了应用。在本文中，我们对KTGS中报告的每个靶标家族进行了药物可及性评估，计算了口袋特性，并使用它们来提取成功的KTGS研究可能的判别因素。越来越少的封闭式口袋出现了趋势，但是总的来说，我们得出的结论是，KTGS方法是通用的，可以不受限制地使用该口袋的理化特性而使用。