Iron deficiency and iron-deficiency anemia are the main worldwide nutritional disorders. A good level of prenatal iron is essential for the correct child neurodevelopment but this association has been poorly investigated. To gather the scientific evidence on the relation between prenatal iron status and child neurodevelopment. To emphasize the importance of personalize the dose and type of supplementation. Wide search strategy was performed in electronic databases for English language articles with no limitations as regards the language or date of publication. Additional studies were selected by hand search. The inclusion criteria were pregnant women without high-risk pregnancy and their children as study population and neurodevelopment as the main outcome. Six RCTs and 13 observational studies were included. The majority concluded that deficit or excess iron during pregnancy injures the mental and psychomotor development of child. Other authors found no association of low iron level with troubles in neurodevelopment, recommended multi-micronutrients instead of iron alone and/or showed inconsistent results. Both iron deficiency as its excess are harmful for the child neurodevelopment. The prenatal iron supplementation should be adjusted for each woman, taking into account the iron stores, some genetic mutation and other health habits.

中文翻译：

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产前铁状态对儿童神经发育和行为的影响：系统评价

缺铁和缺铁性贫血是世界范围内主要的营养失调。良好的产前铁水平对于正确的儿童神经发育至关重要，但对此关联性的研究尚未深入。收集有关产前铁状态与儿童神经发育之间关系的科学证据。为了强调个性化补充剂的剂量和类型的重要性。在英语数据库的电子数据库中执行了广泛的搜索策略，而对语言或出版日期没有任何限制。通过手动搜索选择了其他研究。纳入标准为无高危妊娠的孕妇及其子女为研究人群，以神经发育为主要结果。包括六项RCT和13项观察性研究。大多数人得出结论，怀孕期间铁缺乏或过量会损害儿童的心理和精神运动发育。其他作者发现低铁水平与神经发育障碍没有关联，建议使用多种微量营养素代替单独使用铁和/或结果不一致。铁缺乏症和铁缺乏症都对儿童神经发育有害。应考虑到铁的储存量，一些基因突变和其他健康习惯，为每位女性调整产前补铁。铁缺乏症和铁缺乏症都对儿童神经发育有害。应考虑到铁的储存量，一些基因突变和其他健康习惯，为每位女性调整产前补铁。铁缺乏症和铁缺乏症都对儿童神经发育有害。应考虑到铁的储存量，一些基因突变和其他健康习惯，为每位女性调整产前补铁。