AbstractFor a long time, water has been speculated to play an essential role in the interactions of proteins and cells with artificial biocompatible materials. The current question is how water molecules at the interfaces affect the adsorption of proteins and the adhesion of cells. To answer this question, we introduce recent works that investigated the interfacial behavior of water near self-assembled monolayers (SAMs) by different types of analytical techniques. By combining these findings, we discuss how interfacial water affects the protein and cell resistance of various bioinert SAMs.Recent works revealed that protein and cell resistance of bioinert self-assembled monolayers originates in the physical barrier of the interfacial water. We review the history of the previous works that attempted to clarify the underlying mechanism and discuss prospects to apply the findings to design new biomaterials.

中文翻译：

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生物惰性自组装单层附近的水

摘要 长期以来，人们推测水在蛋白质和细胞与人工生物相容性材料的相互作用中起着至关重要的作用。目前的问题是界面处的水分子如何影响蛋白质的吸附和细胞的粘附。为了回答这个问题，我们介绍了最近的工作，这些工作通过不同类型的分析技术研究了自组装单层 (SAM) 附近水的界面行为。通过结合这些发现，我们讨论了界面水如何影响各种生物惰性 SAM 的蛋白质和细胞抵抗力。最近的工作表明，生物惰性自组装单层的蛋白质和细胞抵抗力起源于界面水的物理屏障。