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Pain, psychiatric comorbidities, and psychosocial stressors associated with Klippel-Trenaunay syndrome
Journal of the American Academy of Dermatology ( IF 13.8 ) Pub Date : 2018-06-05 , DOI: 10.1016/j.jaad.2018.05.1245
Jamison A. Harvey , Henry Nguyen , Katelyn R. Anderson , Jennifer J. Schoch , Emily C. Bendel , David J. Driscoll , Brian A. Palmer , Megha M. Tollefson

Background

Klippel-Trenaunay syndrome (KTS) is characterized by the triad of capillary malformation, venous malformation with or without lymphatic malformation, and limb overgrowth. Patients with KTS have lower scores in general in mental health, physical function, and quality of life than the general population.

Objective

To determine the prevalence of pain and psychiatric comorbidity in patients with KTS.

Methods

A retrospective review of 410 patients with KTS evaluated during 1976-2012 was conducted to identify the presence of pain, psychiatric comorbidities, and psychosocial stressors.

Results

Pain was reported by 260 patients (63.4%) and was associated with any KTS complication (P < .0001) and venous malformations of the lower extremities (P = .0008) and feet (P = .0007). Ninety-five patients had a diagnosed psychiatric condition (23.2%), most commonly depression (15.1%) and anxiety (5.1%). Pain (P = .0016), superficial thrombosis (P = .0269), deep embolic/thrombotic events (P = .0005), gastrointestinal complications (P = .0085), genitourinary complications (P = .0163), and capillary malformation of the hands (P = .0040) were associated with having a psychiatric diagnosis.

Limitations

This is a retrospective study that relied on physician detection and reporting of variables.

Conclusion

Pain and psychiatric conditions, particularly depression and anxiety, are common in patients with KTS. Awareness of the psychosocial impact of KTS and appropriate screening are important.



中文翻译:

与Klippel-Trenaunay综合征相关的疼痛,精神病合并症和心理社会压力源

背景

Klippel-Trenaunay综合征(KTS)的特征是毛细血管畸形,静脉畸形伴或不伴淋巴畸形以及肢体过度生长。与一般人群相比,KTS患者在心理健康,身体机能和生活质量方面总体得分较低。

客观的

确定KTS患者的疼痛和精神病合并症的患病率。

方法

回顾性分析了1976年至2012年期间评估的410例KTS患者,以确定是否存在疼痛,精神病合并症和社会心理压力源。

结果

260例患者报告疼痛(63.4%),并与任何KTS并发症(P  <.0001)和下肢静脉畸形(P  = .0008)和脚(P  = .0007)相关。九十五名患者被诊断出患有精神疾病(23.2%),最常见的是抑郁症(15.1%)和焦虑症(5.1%)。疼痛(P  = .0016),浅表血栓形成(P  = .0269),深部栓塞/血栓形成事件(P  = .0005),胃肠道并发症(P  = .0085),泌尿生殖系统并发症(P  = .0163)和毛细血管畸形(P  = .0040)的手与进行精神病学诊断有关。

局限性

这是一项回顾性研究,依赖于医师检测和报告变量。

结论

疼痛和精神疾病,特别是抑郁症和焦虑症,在KTS患者中很常见。认识KTS的社会心理影响和适当的筛查非常重要。

更新日期:2018-06-05
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