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Reaction between Chalcones, 1,3-Dicarbonyl Compounds, and Elemental Sulfur: A One-Pot Three-Component Synthesis of Substituted Thiophenes
Synlett ( IF 2 ) Pub Date : 2018-06-05 , DOI: 10.1055/s-0037-1610147
Mehdi Adib 1 , Saideh Rajai-Daryasarei 1 , Rahim Pashazadeh 1 , Mehdi Jahani 1 , Massoud Amanlou 2
Affiliation  

A simple and atom-economic synthesis of highly substituted thiophenes is demonstrated. Heating a solution of a chalcone and a ­linear/cyclic 1,3-dicarbonyl compound with elemental sulfur in CH3CN in the presence of NEt3 at 80 °C afforded the corresponding substituted thiophenes in good to excellent yields.

中文翻译:

查耳酮、1,3-二羰基化合物和元素硫之间的反应:取代噻吩的一锅三组分合成

证明了高度取代的噻吩的简单且原子经济的合成。在 NEt3 存在下,在 80°C 下加热查耳酮和具有元素硫的线性/环状 1,3-二羰基化合物在 CH3CN 中的溶液,得到相应的取代噻吩,收率良好至极好。
更新日期:2018-06-05
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