当前位置:
X-MOL 学术
›
Chem. Commun.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
In vivo imaging of hepatocellular nitric oxide using a hepatocyte-targeting fluorescent sensor†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-06-05 00:00:00 , DOI: 10.1039/c8cc03240h Peisheng Zhang 1, 2, 3, 4, 5 , Yong Tian 1, 2, 3, 4, 5 , Hui Liu 1, 2, 3, 4, 5 , Junyu Ren 1, 2, 3, 4, 5 , Hong Wang 1, 2, 3, 4, 5 , Rongjin Zeng 1, 2, 3, 4, 5 , Yunfei Long 1, 2, 3, 4, 5 , Jian Chen 1, 2, 3, 4, 5
Chemical Communications ( IF 4.9 ) Pub Date : 2018-06-05 00:00:00 , DOI: 10.1039/c8cc03240h Peisheng Zhang 1, 2, 3, 4, 5 , Yong Tian 1, 2, 3, 4, 5 , Hui Liu 1, 2, 3, 4, 5 , Junyu Ren 1, 2, 3, 4, 5 , Hong Wang 1, 2, 3, 4, 5 , Rongjin Zeng 1, 2, 3, 4, 5 , Yunfei Long 1, 2, 3, 4, 5 , Jian Chen 1, 2, 3, 4, 5
Affiliation
Imaging of hepatocellular nitric oxide (NO) in vivo is of great importance for understanding its roles in liver diseases, but such an imaging approach is still lacking. Herein, a hepatocyte-targeting fluorescent NO sensor has been fabricated. This sensor exhibits good water solubility, excellent selectivity, and high sensitivity (∼1.62 nM). The cells and in vivo imaging experiments reveal that Gal-RhB facilitates the visualization of hepatocellular NO in both HepG2 cells and zebrafish. These results demonstrate that Gal-RhB may be a promising tool for studying the function of NO in NO-associated liver diseases.
中文翻译:
使用靶向肝细胞的荧光传感器对肝细胞一氧化氮进行体内成像†
体内肝细胞一氧化氮(NO)的成像对于了解其在肝脏疾病中的作用非常重要,但是仍然缺乏这种成像方法。在此,已经制造了靶向肝细胞的荧光NO传感器。该传感器具有良好的水溶性,出色的选择性和高灵敏度(〜1.62 nM)。细胞和体内成像实验表明,Gal-RhB促进了HepG2细胞和斑马鱼中肝细胞NO的可视化。这些结果表明,Gal-RhB可能是研究NO相关肝病中NO功能的有前途的工具。
更新日期:2018-06-05
中文翻译:
使用靶向肝细胞的荧光传感器对肝细胞一氧化氮进行体内成像†
体内肝细胞一氧化氮(NO)的成像对于了解其在肝脏疾病中的作用非常重要,但是仍然缺乏这种成像方法。在此,已经制造了靶向肝细胞的荧光NO传感器。该传感器具有良好的水溶性,出色的选择性和高灵敏度(〜1.62 nM)。细胞和体内成像实验表明,Gal-RhB促进了HepG2细胞和斑马鱼中肝细胞NO的可视化。这些结果表明,Gal-RhB可能是研究NO相关肝病中NO功能的有前途的工具。