当前位置: X-MOL 学术J. Colloid Interface Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Bridging the gap: Optimized fabrication of robust titania nanostructures on complex implant geometries towards clinical translation
Journal of Colloid and Interface Science ( IF 9.9 ) Pub Date : 2018-06-04 , DOI: 10.1016/j.jcis.2018.06.004
Tao Li , Karan Gulati , Na Wang , Zhenting Zhang , Sašo Ivanovski

Electrochemically anodized titanium surfaces with titania nanostructures (TNS; nanopores, nanotubes, etc.) have been widely applied as therapeutic bone/dental implant modifications. Despite the numerous advancements in the field of electrochemical anodization (EA), in terms of translation into the current implant market, research gaps in this domain include the lack of fabrication optimization, performed on a substrate of conventional implant surface/geometry, and inadequate mechanical stability. In the current study, we investigate the role of substrate pre-treatment on achieving desired nanotopographies for the purpose of reproducing optimized nanostructures on the complex geometry of commercial implant surfaces, as well as in-depth mechanical stability testing of these nano-engineered coatings. The results confirmed that: (a) substrate polishing/smoothening may be insignificant with respect to fabrication of well-ordered and high quality TNS on micro-rough implants with preserved underlying micro-roughness; (b) optimized outcomes can be successfully translated onto complex geometries characteristic of the current implant market, including dental implant abutments and screws (also applicable to a wider implant market including orthopaedics); (c) mechanical stability testing revealed improved modulus and hardness values as compared to conventional nanotubes/pores. We believe that such optimization advances the existing knowledge of titanium anodization and anodized implants towards integration into the current implant market and successful clinical translation.



中文翻译:

缩小差距:在复杂的植入物几何结构上优化制造坚固的二氧化钛纳米结构,以实现临床翻译

具有二氧化钛纳米结构(TNS;纳米孔,纳米管等)的电化学阳极氧化钛表面已被广泛用作治疗性骨/牙齿植入物修饰。尽管在电化学阳极氧化(EA)领域取得了许多进步,但在转变为当前植入物市场方面,该领域的研究空白包括缺乏制造优化,在常规植入物表面/几何形状的基板上进行的加工以及机械性能不足。稳定。在当前的研究中,我们调查了基材预处理在实现所需纳米形貌方面的作用,目的是在商用植入物表面的复杂几何形状上重现优化的纳米结构,并对这些纳米工程涂层进行深入的机械稳定性测试。结果证实:(a)对于在保留了底层微观粗糙度的微观粗糙植入物上制造有序且高质量的TNS而言,基材的抛光/平滑处理可能并不重要;(b)优化的结果可以成功地转化为当前植入物市场的复杂几何特征,包括牙种植体基台和螺钉(也适用于包括骨科在内的更广泛的植入物市场);(c)机械稳定性测试表明,与常规的纳米管/孔相比,模量和硬度值有所提高。我们相信,这种优化将使钛阳极氧化和阳极氧化植入物的现有知识进一步发展,并融入当前的植入物市场并成功进行临床翻译。

更新日期:2018-06-04
down
wechat
bug