Furan is a common food contaminant and environmental pollutant. Spirulina platensis (SP) is a blue–green algae extensively used as therapeutic and health supplements. This study aimed to explore the probable beneficial role of SP against the influence of furan on reproductive system of male rats. Adult male rats were divided into control, vehicle control, SP (300 mg/kg bwt/ day, 7 days), furan (16 mg/kg bwt/ day,30 day), SP/furan, furan/SP and furan+SP groups. Hematology, sperm count, sperm morphology, serum testosterone (TES), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and estradiol (E2) levels, reduced glutathione (GSH), malondialdehyde (MDA), testicular enzymes, and pro inflammatory cytokines were estimated. In addition, histopathology of testis and seminal vesicles and apoptosis were evaluated. Anaemia, leukocytosis, and reduced gonadosomatic index were observed in the furan treated group. TES, LH, FSH, E2, and GSH were significantly decreased following furan treatment. MDA, testicular enzymes, and pro inflammatory cytokines were significantly incremented in testis of furan treated rats. Furan induced apoptic changes in testis. SP significantly counteracted furan reprotoxic impacts, particularly at co-exposure. Conclusively, these findings verified that SP could be candidate therapy against furan reprotoxic impacts.

呋喃是一种常见的食品污染物和环境污染物。螺旋藻（SP）是一种蓝绿色藻类，广泛用作治疗和健康补品。本研究旨在探讨SP对呋喃对雄性大鼠生殖系统影响的可能的有益作用。将成年雄性大鼠分为对照，媒介物对照，SP（300mg / kg bwt /天，7天），呋喃（16mg / kg bwt /天，30天），SP /呋喃，呋喃/ SP和呋喃+ SP。组。血液学，精子数量，精子形态，血清睾丸激素（TES），促黄体生成激素（LH），促卵泡激素（FSH）和雌二醇（E2）水平，降低的谷胱甘肽（GSH），丙二醛（MDA），睾丸酶和脯氨酸估计炎性细胞因子。另外，评估了睾丸和精囊的组织病理学和细胞凋亡。在呋喃治疗组中观察到贫血，白细胞增多和性腺机能指数降低。TES，LH，FSH，E2，呋喃处理后，GSH和GSH显着降低。呋喃处理的大鼠睾丸中的MDA，睾丸酶和促炎性细胞因子显着增加。呋喃诱导睾丸的凋亡变化。SP显着抵消了呋喃的生殖毒性影响，尤其是在共同暴露时。最终，这些发现证实了SP可以作为抗呋喃生殖毒性影响的候选疗法。