Changing faces: Owing to the amphiphilic nature of enzymatically assembled DNAzyme–surfactants, they can first enable cellular uptake and can then, after enzyme‐triggered disassembly, traverse lipid bilayers and gain access to the mRNA within the cell's cytosol. Cleavage of the mRNA target by the DNAzyme–surfactant results in sequence‐specific gene knockdown without the need for external transfection agents.

中文翻译：

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酶促连接的DNA表面活性剂：揭示疏水修饰的DNA用于细胞内基因调控

变化的面孔：由于酶组装的DNAzyme-表面活性剂具有两亲性，它们首先可以使细胞吸收，然后在酶触发分解后可以遍历脂质双层并进入细胞质中的mRNA。DNAzyme-表面活性剂对mRNA靶标的切割可导致序列特异性基因敲低，而无需外部转染剂。