Zinc (Zn) deficiency is a clinical consequence of brain injury that can result in neuropathological outcomes that are exacerbated with age. Here, we present laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) imaging data showing modulation of brain Zn levels by the disaccharide trehalose in aged mice following a controlled cortical impact model of traumatic brain injury. In this proof-of-concept study, trehalose induced an increase in brain zinc levels, providing important preliminary data for larger studies using this simple carbohydrate as a modulator of this essential micronutrient in traumatic brain injury. Our results may have further implications for the treatment of a variety of neurodegenerative diseases and other disorders of the nervous system.

中文翻译：

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在控制性脑损伤的小鼠脑外伤模型中，海藻糖可升高脑锌水平

锌缺乏是脑损伤的临床后果，可导致神经病理学结果随着年龄的增长而加剧。在这里，我们介绍了激光消融电感耦合等离子体质谱（LA-ICP-MS）成像数据，显示了在大脑皮层外伤模型受到控制后，老年小鼠中的二糖海藻糖对脑锌水平的调节作用。在这项概念验证研究中，海藻糖诱导了脑锌水平的增加，为使用这种简单碳水化合物作为创伤性脑损伤中这种必需的微量营养素的调节剂的大规模研究提供了重要的初步数据。我们的结果可能对多种神经退行性疾病和神经系统其他疾病的治疗具有进一步的意义。