Aims:

To compare the antibacterial activity of alexidine (ALX) alone or as a final irrigant in combination with sodium hypochlorite (NaOCl), with the most common canal irrigants, NaOCl and chlorhexidine (CHX).

Materials and methods:

Ninety-four root fragments from extracted human teeth were infected with Enterococcus faecalis for 24 h and then distributed into 4 groups of 20 fragments each. The NaOCl, CHX and ALX groups were immersed in 1 ml of 2.5% NaOCl, 2% CHX, and 1% ALX for 10 min, respectively. The samples of the NaOCl+ALX group were immersed in 1 ml of 2.5% NaOCl for 10 min followed by 1% ALX for 10 min. Bacteriological samples were taken, cultured, and the colony-forming units were counted.

Results:

There was no significant differences among the experimental groups (P>0.05) except for the comparisons CHX versus ALX and NaOCl+ALX versus ALX (P=0.004). ALX alone was the worst irrigant. CHX and NaOCl+ALX eradicated all bacteria. All experimental groups were significantly more effective than the control group immersed in saline (P<0.05).

Conclusions:

The antibacterial effect of ALX alone was inferior to 2% CHX and 2.5% NaOCl. However, the combination of NaOCl with ALX as a final irrigant eradicated the biofilms.

中文翻译：

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单独使用阿来昔定或作为最终冲洗剂与次氯酸钠和洗必泰的抗菌活性比较

目标：

比较阿来昔定 (ALX) 单独或作为最终冲洗剂与次氯酸钠 (NaOCl) 组合的抗菌活性，以及​​最常见的根管冲洗剂 NaOCl 和洗必泰 (CHX)。

材料和方法：

取自人类牙齿的 94 个牙根碎片用粪肠球菌感染24 h，然后分成 4 组，每组 20 个碎片。NaOCl、CHX 和 ALX 组分别浸入 1 ml 2.5% NaOCl、2% CHX 和 1% ALX 中 10 分钟。NaOCl+ALX 组的样品在 1 ml 2.5% NaOCl 中浸泡 10 分钟，然后在 1% ALX 中浸泡 10 分钟。取细菌样本，培养，计数菌落形成单位。

结果：

除 CHX 与 ALX 和 NaOCl+ALX 与 ALX 的比较（P = 0.004）外，各实验组之间无显着差异（P > 0.05）。仅 ALX 是最糟糕的冲洗剂。CHX 和 NaOCl+ALX 根除所有细菌。所有实验组均显着优于生理盐水浸泡的对照组（P <0.05）。

结论：

单独使用 ALX 的抗菌效果不如 2% CHX 和 2.5% NaOCl。然而，NaOCl 与 ALX 作为最终冲洗剂的组合消除了生物膜。