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Dual‐Crosslinked Amorphous Polysaccharide Hydrogels Based on Chitosan/Alginate for Wound Healing Applications
Macromolecular Rapid Communications ( IF 4.6 ) Pub Date : 2018-05-31 , DOI: 10.1002/marc.201800069
Yang Hu 1 , Zhenyan Zhang 1 , Yang Li 1 , Xiaokang Ding 1 , Dawei Li 2 , Chuanan Shen 2 , Fu-Jian Xu 1
Affiliation  

Development of advanced wound dressing materials with rapid healing rates is in urgent demand for wound cares. A suitable microenvironment will promote cell proliferation and migration, which benefits to early wound healing and prevents inflammations and scars. In this work, N‐carboxymethyl chitosan‐ and alginate‐based hydrogels are prepared via both electrostatic interaction and divalent chelation with epidermal growth factor (EGF) payload to promote the cell proliferation and wound healing. The dual‐crosslinked hydrogels are investigated in terms of rheology, water retention ability, and the release rate of EGF. Moreover, such amorphous hydrogel can promote cell proliferation and accelerate wound healing. The present study demonstrates that dual‐crosslinked polysaccharide hydrogels are promising in wound care management.

中文翻译:

基于壳聚糖/藻酸盐的双交联无定形多糖水凝胶在伤口愈合中的应用

对伤口护理的迫切需求是开发具有快速治愈率的高级伤口敷料。合适的微环境将促进细胞增殖和迁移,这有利于伤口的早期愈合并防止炎症和疤痕。在这项工作中,N基于羧甲基壳聚糖和藻酸盐的水凝胶是通过静电相互作用和与表皮生长因子(EGF)有效载荷的二价螯合制备的,以促进细胞增殖和伤口愈合。对双交联水凝胶进行了流变学,保水能力和EGF释放速率方面的研究。而且,这种无定形水凝胶可以促进细胞增殖并加速伤口愈合。本研究表明,双交联多糖水凝胶在伤口护理管理中很有前途。
更新日期:2018-05-31
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