Adenoma miss rates in colonoscopy are unacceptably high, especially for sessile serrated adenomas / polyps (SSA/Ps) and in high-risk populations, such as patients with Lynch syndrome. Detection rates may be improved by fluorescence molecular endoscopy (FME), which allows morphological visualization of lesions with high-definition white-light imaging as well as fluorescence-guided identification of lesions with a specific molecular marker. In a clinical proof-of-principal study, we investigated FME for colorectal adenoma detection, using a fluorescently labelled antibody (bevacizumab-800CW) against vascular endothelial growth factor A (VEGFA), which is highly upregulated in colorectal adenomas.

中文翻译：

---

大范围荧光分子内窥镜检查可能识别结直肠腺瘤的红旗病

结肠镜检查中的腺瘤漏诊率很高，令人难以接受，特别是对于无柄锯齿状腺瘤/息肉（SSA / Ps）和高危人群，例如Lynch综合征患者。荧光分子内窥镜检查（FME）可以提高检出率，荧光分子内窥镜检查（FME）可通过高清白光成像对病变进行形态学可视化，并通过荧光引导的特定分子标记识别病变。在一项主要的临床证据研究中，我们使用了针对大肠腺瘤中高度上调的血管内皮生长因子A（VEGFA）的荧光标记抗体（bevacizumab-800CW），对FME用于大肠腺瘤的检测进行了研究。