Rationale: Nasopharyngeal carcinoma (NPC) is the most frequent head and neck tumor in South China. The presence of cancer stem cells (CSCs) in NPC contributes to tumor maintenance and therapeutic resistance, while the ability of CSCs to escape from the apoptosis pathway may render them the resistant property to the therapies. Inhibitor of apoptosis proteins family proteins (IAPs), which are overexpressed in nasopharyngeal carcinoma stem cells, may play an important role in maintaining nasopharyngeal cancer stem cell properties. Here, we develop a novel CSC-targeting strategy to treat NPC through inhibiting IAPs.

中文翻译：

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XIAP限制了Sox2的自噬降解，是鼻咽癌干细胞的治疗靶标。

理由：鼻咽癌（NPC）是华南地区最常见的头颈部肿瘤。NPC中癌症干细胞（CSC）的存在有助于肿瘤的维持和治疗抗性，而CSC从凋亡途径中逃逸的能力可能使其具有抗药性。在鼻咽癌干细胞中过表达的凋亡蛋白家族蛋白（IAP）抑制剂可能在维持鼻咽癌干细胞特性中起重要作用。在这里，我们开发了一种新型的CSC靶向策略，可通过抑制IAP来治疗NPC。