Purpose: Glioblastoma is the most common and aggressive type of primary brain malignancy and is associated with a poor prognosis. Previously, we found that phosphatase of regenerating liver-3 (PRL-3) was significantly up-regulated in glioblastoma as determined by a microarray analysis. However, the function of PRL-3 in glioblastoma remains unknown. We aimed to investigate the clinical relationship between PRL-3 and glioblastoma, and uncover the mechanisms of PRL-3 in the process of glioblastoma.

中文翻译：

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PRL-3是潜在的胶质母细胞瘤预后标志物，并通过ERK和JNK途径增强MMP7来促进胶质母细胞瘤进展

目的：胶质母细胞瘤是原发性脑恶性肿瘤中最常见和最具侵略性的类型，其预后不良。以前，我们发现胶质母细胞瘤中再生肝3（PRL-3）的磷酸酶显着上调，这是通过微阵列分析确定的。但是，PRL-3在胶质母细胞瘤中的功能仍然未知。目的探讨PRL-3与胶质母细胞瘤的临床关系，揭示PRL-3在胶质母细胞瘤过程中的作用机制。