Background: Circulating tumor cells (CTCs) are a burgeoning topic in cancer biomarker discovery research with minimal invasive blood draws. CTCs can be used as potential biomarkers for disease prognosis, early cancer diagnosis and pharmacodynamics. However, the extremely low abundance of CTCs limits their clinical utility because of technical challenges such as the isolation and subsequent detailed molecular and functional characterization of rare CTCs from patient blood samples.

中文翻译：

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明胶纳米颗粒包覆的硅珠用于高纯度非均质循环肿瘤细胞的密度选择性捕获和释放

背景：循环肿瘤细胞（CTC）是癌症生物标志物发现研究中新兴的话题，其具有最小的侵入性血液抽取。CTC可用作疾病预后，早期癌症诊断和药效学的潜在生物标志物。但是，由于技术难题，例如从患者血液样本中分离稀有CTC以及随后进行详细的分子和功能表征等技术挑战，CTC的极低含量限制了其临床应用。