Abstract It is appealing to develop a facile way to prepare a binary CT contrast agent with good biocompatibility and CT contrast efficiency for potential clinical applications. In this work, a novel binary CT contrast agent based on the biocompatible nano-hydroxyapatite (nHAp, the main inorganic component of human bone and teeth) was prepared facilely and rapidly through doping two kinds of CT contrast ions (Ba2+ and Ho3+) into the nHAp host via microwave-assisted synthesis. The Ba/Ho co-doped nHAp with pure nHAp phase composition and good mono-dispersion was obtained simply with microwave heating for 30 min. The as prepared CT contrast agent is very promising as a novel binary CT contrast agent for CT imaging.

中文翻译：

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微波辅助合成单分散 Ba/Ho 共掺杂纳米羟基磷灰石作为二元 CT 成像造影剂的潜在应用

摘要 开发一种简便的方法来制备具有良好生物相容性和 CT 对比效率的二元 CT 对比剂具有潜在的临床应用价值。在这项工作中，通过将两种 CT 对比离子（Ba2+ 和 Ho3+）掺杂到生物相容性纳米羟基磷灰石（nHAp，人​​体骨骼和牙齿的主要无机成分）中，制备了一种基于生物相容性纳米羟基磷灰石（nHAp）的新型二元 CT 造影剂。通过微波辅助合成的 nHAp 宿主。简单地通过微波加热 30 分钟即可获得具有纯 nHAp 相组成和良好单分散性的 Ba/Ho 共掺杂 nHAp。所制备的CT对比剂作为一种新型的CT成像二元CT对比剂是非常有前途的。