Synthetic and materials chemistry initiatives have enabled the translation of the macromolecular functions of biology into synthetic frameworks. These explorations into alternative chemistries of life attempt to capture the versatile functionality and adaptability of biopolymers in new orthogonal scaffolds. Information storage and transfer, however, so beautifully represented in the central dogma of biology, require multiple components functioning synergistically. Over a single decade, the emerging field of systems chemistry has begun to catalyze the construction of mutualistic biopolymer networks, and this review begins with the foundational small-molecule-based dynamic chemical networks and peptide amyloid-based dynamic physical networks on which this effort builds. The approach both contextualizes the versatile approaches that have been developed to enrich chemical information in synthetic networks and highlights the properties of amyloids as potential alternative genetic elements. The successful integration of both chemical and physical networks through β-sheet assisted replication processes further informs the synergistic potential of these networks. Inspired by the cooperative synergies of nucleic acids and proteins in biology, synthetic nucleic-acid–peptide chimeras are now being explored to extend their informational content. With our growing range of synthetic capabilities, structural analyses, and simulation technologies, this foundation is radically extending the structural space that might cross the Darwinian threshold for the origins of life as well as creating an array of alternative systems capable of achieving the progressive growth of novel informational materials.

中文翻译：

---

在系统化学中实现生物聚合物协同作用

合成化学和材料化学倡议已使生物学的大分子功能转化为合成框架。这些对生命替代化学方法的探索试图捕获新型正交支架中生物聚合物的通用功能和适应性。但是，信息的存储和传输在生物学的核心教条中如此精美地表现出来，它需要多个组件协同工作。在过去的十年中，系统化学的新兴领域已开始催化相互关系的生物聚合物网络的构建，而本综述首先从基于小分子的动态化学网络和基于肽淀粉样蛋白的动态物理网络开始，以此为基础。该方法既结合了为丰富合成网络中的化学信息而开发的通用方法，又突显了淀粉样蛋白作为潜在替代遗传元件的特性。通过β-折叠辅助复制过程成功整合了化学和物理网络，进一步揭示了这些网络的协同潜力。受生物学中核酸和蛋白质的协同增效作用的启发，目前正在探索合成的核酸-肽嵌合体，以扩展其信息含量。随着我们不断扩展的综合功能，结构分析和仿真技术，