The importance of the cell wall to the viability of the bacterium is underscored by the breadth of antibiotic structures that act by blocking key enzymes that are tasked with cell-wall creation, preservation, and regulation. The interplay between cell-wall integrity, and the summoning forth of resistance mechanisms to deactivate cell-wall-targeting antibiotics, involves exquisite orchestration among cell-wall synthesis and remodeling and the detection of and response to the antibiotics through modulation of gene regulation by specific effectors. Given the profound importance of antibiotics to the practice of medicine, the assertion that understanding this interplay is among the most fundamentally important questions in bacterial physiology is credible. The enigmatic regulation of the expression of the AmpC β-lactamase, a clinically significant and highly regulated resistance response of certain Gram-negative bacteria to the β-lactam antibiotics, is the exemplar of this challenge. This review gives a current perspective to this compelling, and still not fully solved, 35-year enigma.

中文翻译：

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革兰氏阴性菌的细胞壁回收及其与抗生素耐药性的关系

抗生素结构的广泛性强调了细胞壁对细菌生存力的重要性，这些抗生素结构通过阻断负责细胞壁形成、保存和调节的关键酶来发挥作用。细胞壁完整性与耐药机制的产生之间的相互作用，使细胞壁靶向抗生素失活，涉及细胞壁合成和重塑之间的精细协调，以及通过特定基因调节基因调控来检测和响应抗生素。效应器。鉴于抗生素对医学实践的深远重要性，理解这种相互作用是细菌生理学中最根本的重要问题之一的断言是可信的。AmpC β-内酰胺酶表达的神秘调节是这一挑战的典型例子，AmpC β-内酰胺酶是某些革兰氏阴性细菌对 β-内酰胺抗生素的一种具有临床意义且高度调节的耐药反应。这篇评论对这个令人信服但仍未完全解决的 35 年之谜提供了当前的视角。