Four new dihydrobenzofuran neolignans 1a/1b and 2a/2b were isolated from the fruit of Rubus ideaus. 1a/1b and 2a/2b as two pairs of enantiomers were separated on a chiral chromatographic column. Their structures were determined using a suite of techniques including 1D and 2D NMR, HRESIMS, together with theoretical electronic circular dichroism (ECD) calculation. All compounds were evaluated for their inhibition of self-induced Aβ_1–42 aggregation. Compounds 1b and 2a exhibited optimal Aβ_1–42 aggregation inhibition capability, with an inhibition potency of 81.6% and 83.4% at 20 μM, respectively. Additionally, molecular docking was performed to identify the possible factor responsible for the enantioselectivity in the anti-Aβ_1–42 aggregation activity.

从悬钩子的果实中分离出4个新的二氢苯并呋喃新木脂1a / 1b和2a / 2b。1a / 1b和2a / 2b作为两对对映异构体在手性色谱柱上分离。使用一系列技术（包括1D和2D NMR，HRESIMS）以及理论电子圆二色性（ECD）计算，确定了它们的结构。所有化合物对抑制自诱导A的评价β _1-42聚集。化合物1B和图2a展出最佳甲β _1-42聚集抑制能力，具有81.6％的抑制效力和83.4％，在20 μ男，分别。另外，进行分子对接确定负责在抗-A的对映可能的因子β _1-42聚集活性。