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Modified Magnesium Hydroxide Nanoparticles Inhibit the Inflammatory Response to Biodegradable Poly(lactide-co-glycolide) Implants
ACS Nano ( IF 17.1 ) Pub Date : 2018-05-29 00:00:00 , DOI: 10.1021/acsnano.8b02365
Eugene Lih 1 , Chang Hun Kum 1, 2 , Wooram Park 3 , So Young Chun 4 , Youngjin Cho 5 , Yoon Ki Joung 1, 6 , Kwang-Sook Park 1 , Young Joon Hong 7 , Dong June Ahn 2 , Byung-Soo Kim 8 , Tae Gyun Kwon 9 , Myung Ho Jeong 7 , Jeffrey A. Hubbell 10 , Dong Keun Han 3
Affiliation  

Biodegradable polymers have been extensively used in biomedical applications, ranging from regenerative medicine to medical devices. However, the acidic byproducts resulting from degradation can generate vigorous inflammatory reactions, often leading to clinical failure. We present an approach to prevent acid-induced inflammatory responses associated with biodegradable polymers, here poly(lactide-co-glycolide), by using oligo(lactide)-grafted magnesium hydroxide (Mg(OH)2) nanoparticles, which neutralize the acidic environment. In particular, we demonstrated that incorporating the modified Mg(OH)2 nanoparticles within degradable coatings on drug-eluting arterial stents efficiently attenuates the inflammatory response and in-stent intimal thickening by more than 97 and 60%, respectively, in the porcine coronary artery, compared with that of drug-eluting stent control. We also observed that decreased inflammation allows better reconstruction of mouse renal glomeruli in a kidney tissue regeneration model. Such modified Mg(OH)2 nanoparticles may be useful to extend the applicability and improve clinical success of biodegradable devices used in various biomedical fields.

中文翻译:

改性氢氧化镁纳米粒子抑制对可生物降解的聚(丙交酯-共-乙交酯)植入物的炎症反应

可生物降解的聚合物已广泛用于从再生医学到医疗器械的生物医学应用中。但是,降解产生的酸性副产物会产生剧烈的炎症反应,通常会导致临床失败。我们提出了一种方法,通过使用中和酸性环境的低聚(丙交酯)接枝的氢氧化镁(Mg(OH)2)纳米颗粒,防止与可生物降解的聚合物(此处为聚(丙交酯-共-乙交酯))相关的酸诱导的炎症反应。。特别是,我们证明了掺入改性的Mg(OH)2与药物洗脱支架对照相比,药物洗脱动脉支架上可降解涂层中的纳米颗粒可分别使猪冠状动脉的炎症反应和支架内膜内膜增厚分别减轻97%和60%以上。我们还观察到,炎症减少可以使肾脏组织再生模型中的小鼠肾小球更好地重建。此类改性的Mg(OH)2纳米粒子可用于扩展适用性并提高在各种生物医学领域中使用的可生物降解设备的临床成功率。
更新日期:2018-05-29
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