The US National Cancer Institute’s (NCI) Natural Product Repository is one of the world’s largest, most diverse collections of natural products containing over 230,000 unique extracts derived from plant, marine, and microbial organisms that have been collected from biodiverse regions throughout the world. Importantly, this national resource is available to the research community for the screening of extracts and the isolation of bioactive natural products. However, despite the success of natural products in drug discovery, compatibility issues that make extracts challenging for liquid handling systems, extended timelines that complicate natural product-based drug discovery efforts and the presence of pan-assay interfering compounds have reduced enthusiasm for the high-throughput screening (HTS) of crude natural product extract libraries in targeted assay systems. To address these limitations, the NCI Program for Natural Product Discovery (NPNPD), a newly launched, national program to advance natural product discovery technologies and facilitate the discovery of structurally defined, validated lead molecules ready for translation will create a prefractionated library from over 125,000 natural product extracts with the aim of producing a publicly-accessible, HTS-amenable library of >1,000,000 fractions. This library, representing perhaps the largest accumulation of natural-product based fractions in the world, will be made available free of charge in 384-well plates for screening against all disease states in an effort to reinvigorate natural product-based drug discovery.

中文翻译：

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NCI天然产物发现计划：用于高通量筛选的天然产物级分的公共可访问库

美国国家癌症研究所（NCI）天然产物库是世界上最大，最多样化的天然产物集合之一，其中包含超过23万种独特的植物，海洋和微生物的提取物，这些提取物是从世界各地的生物多样性地区收集的。重要的是，该国家资源可供研究界用于提取物的筛选和生物活性天然产物的分离。然而，尽管天然产物在药物研发中取得了成功，但相容性问题使提取物对液体处理系统具有挑战性，延长了基于天然产物的药物开发工作的时间，并增加了泛测定干扰化合物的存在，降低了针对目标测定系统中天然产物提取物文库的高通量筛选（HTS）的热情。为了解决这些局限性，NCI天然产物发现计划（NPNPD）是一项新近启动的国家计划，旨在促进天然产物发现技术的发展，并促进发现已准备翻译的结构明确，经过验证的铅分子，这将创建一个超过125,000个预分类库天然产物提取物，目的是产生可公开访问的，符合HTS要求的> 1,000,000馏分的文库。该库可能代表了世界上最大的基于天然产物的馏分积累，