Large-scale Artemisinin–Piperaquine Mass Drug Administration With or Without Primaquine Dramatically Reduces Malaria in a Highly Endemic Region of Africa,Clinical Infectious Diseases

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Large-scale Artemisinin–Piperaquine Mass Drug Administration With or Without Primaquine Dramatically Reduces Malaria in a Highly Endemic Region of Africa
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2018-04-24 , DOI: 10.1093/cid/ciy364
Changsheng Deng ₁ , Bo Huang ₁ , Qi Wang _{1,

2} , Wanting Wu ₂ , Shaoqin Zheng ₂ , Hongying Zhang ₂ , Di Li ₂ , Danghong Feng ₂ , Guoming Li ₂ , Linlu Xue ₂ , Tao Yang ₂ , Fei Tuo ₂ , Fouad Mohadji ₃ , Xin-Zhuan Su ₄ , Qin Xu ₁ , Zhibing Wu ₅ , Li Lin ₅ , Jiuyao Zhou ₆ , Hong Yan ₂ , Affane Bacar ₇ , Kamal Said Abdallah ₇ , Rachadi A Kéké ₇ , Ahamada Msa Mliva ₃ , Moussa Mohamed ₃ , Xinhua Wang ₈ , Shiguang Huang ₉ , Fatihou Oithik ₃ , Xiao-Bo Li ₂ , Fangli Lu _{10,

11} , Michael P Fay ₁₂ , Xiao-Hong Liu ₁₃ , Thomas E Wellems ₄ , Jianping Song _{1,

2}

Affiliation

Institute of Tropical Medicine, People's Republic of China.
Science and Technology Park, Guangzhou University of Chinese Medicine, Guangdong, People's Republic of China.
Ministry of Health Comoros, Moroni, Union of Comoros, Bethesda, Maryland.
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
First Affiliated Hospital, People's Republic of China.
Traditional Chinese Medicine College, Guangzhou University of Chinese Medicine, Guangdong, People's Republic of China.
National Malaria Control Programme, Moroni, Union of Comoros, People's Republic of China.
Guangzhou Medical University, People's Republic of China.
School of Stomatology, Jinan University, People's Republic of China.
Department of Parasitology, Zhongshan School of Medicine, People's Republic of China.
Key Laboratory of Tropical Disease Control in Ministry of Education, Sun Yat-sen University, Guangdong, People's Republic of China.
Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangdong, People's Republic of China.

Mass drug administration (MDA), with or without low-dose primaquine (PMQ_LD), is being considered for malaria elimination programs. The potential of PMQ_LD to block malaria transmission by mosquitoes must be balanced against liabilities of its use.

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