Abstract Phyllantus niruri Linn or stonebreaker plant has recently received increasing interest for use as a pharmaceutical drug form. However, modernization by means of quality control and standardization of medicinal herbal plants applications as pharmaceutical drug forms is critical for international acceptance. Therefore, using a spouted bed, the coating process of stonebreaker granules was modeled to understand the critical parameters influencing coating efficiency, particle growth and agglomeration index. A 23 factorial experimental design using atomization pressure, feed flow rate and inlet temperature was implemented. Results revealed coating efficiencies ranging from 40% to 93%, mean particle growths of 9.7% and agglomeration indexes, which is an undesirable result, close to 0%. Initially models revealed that low temperatures/low coating flow rate or high temperatures/high coating flow rate provided more efficient coating. Further analysis proved that is relative humidity, a scalable variable, the most critical parameter on process efficiency.

中文翻译：

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珍珠草颗粒喷床包衣工艺

摘要 Phyllantus niruri Linn 或碎石植物最近作为药物形式越来越受到关注。然而，通过质量控制和标准化药用植物作为药物形式的应用进行现代化对于国际认可至关重要。因此，使用喷射床，对碎石颗粒的包衣过程进行建模，以了解影响包衣效率、颗粒生长和团聚指数的关键参数。实施了使用雾化压力、进料流速和入口温度的 23 因子实验设计。结果表明，涂​​层效率为 40% 至 93%，平均颗粒增长为 9.7%，附聚指数接近 0%，这是不希望的结果。最初的模型显示低温/低涂层流速或高温/高涂层流速提供更有效的涂层。进一步的分析证明，相对湿度是一个可扩展的变量，是工艺效率的最关键参数。