Two different green biocatalytic methods were investigated for the transformation of 5-hydroxymethylfurfural (HMF) to valuable disubstituted furan derivatives. 2,5-bis(hydroxymethyl) furan (BHMF) was obtained by biocatalytic reduction using lyophilized plant tissues. 5-(hydroxymethyl)furfurylamine (HMFA) was synthesized by amination transfer reaction catalysed by immobilized transaminase enzymes. By choosing suitable reaction conditions both products were obtained with high yields in water as reaction medium, at room temperature or 50 °C within a reaction time of 48 and 24 h. The studied protocols represent environmentally benign and promising green catalytic processes, generating less waste than other synthetic approaches.

研究了两种不同的绿色生物催化方法，将5-羟甲基糠醛（HMF）转化为有价值的二取代呋喃衍生物。通过使用冻干的植物组织的生物催化还原获得2，5-双（羟甲基）呋喃（BHMF）。通过固定化转氨酶催化的胺转移反应合成了5-（羟甲基）糠胺（HMFA）。通过选择合适的反应条件，在室温或50°C下，反应时间为48和24小时，在水中作为反应介质，可以高收率获得两种产物。所研究的方案代表了对环境有益的和有前途的绿色催化过程，与其他合成方法相比，产生的废物更少。