P(O)–X (X = S, N, O, P) bond-containing compounds have extensive application in medicinal chemistry, agrochemistry, and material chemistry. These useful organophosphorus compounds also have many applications in organic synthesis. In light of the importance of titled compounds, there is continuing interest in the development of synthetic methods for P(O)–X bonds construction. In the last 4 years, the direct coupling reaction of P(O)–H compounds with thiols, alcohols, and amines/amides has received much attention because of the atom-economic character. This review aims to give an overview of new developments in cross-dehydrogenative coupling reactions between P(O)–H and X–H (X = S, N, O, P) bonds, with special emphasis on the mechanistic aspects of the reactions.

含P（O）–X（X = S，N，O，P）的含键化合物在药物化学，农业化学和材料化学中具有广泛的应用。这些有用的有机磷化合物在有机合成中也有许多应用。鉴于标题化合物的重要性，人们一直对开发P（O）-X键结构的合成方法感兴趣。在过去的四年中，由于原子经济特性，P（O）–H化合物与硫醇，醇和胺/酰胺的直接偶联反应受到了广泛关注。这篇综述旨在概述P（O）–H和X–H（X = S，N，O，P）键之间的交叉脱氢偶联反应的新进展，特别着重于反应的机理方面。 。