Aryl pyrazoles are well recognized class of heterocyclic compounds found in several commercially available drugs. Owing to their significance in medicinal chemistry, in this current account we have synthesized a series of suitably substituted aryl pyrazole by employing Suzuki cross-coupling reaction. All compounds were evaluated for inhibition of mushroom tyrosinase enzyme both in vitro and in silico. Compound 3f (IC₅₀ = 1.568 ± 0.01 µM) showed relatively better potential compared to reference kojic acid (IC₅₀ = 16.051 ± 1.27 µM). A comparative docking studies showed that compound 3f have maximum binding affinity against mushroom tyrosinase (PDBID: 2Y9X) with binding energy value (−6.90 kcal/mol) as compared to Kojic acid. The 4-methoxy group in compound 3f shows 100% interaction with Cu. Compound 3f displayed hydrogen binding interaction with His61 and His94 at distance of 1.71 and 1.74 Å which might be responsible for higher activity compared to Kojic acid.

芳基吡唑是在几种市售药物中发现的公认的一类杂环化合物。由于它们在药物化学中的重要性，在目前的情况下，我们已经通过使用铃木交叉偶联反应合成了一系列适当取代的芳基吡唑。评价了所有化合物在体外和计算机上对蘑菇酪氨酸酶的抑制作用。 与参比曲酸（IC ₅₀  = 16.051±1.27 µM）相比，化合物3f（IC ₅₀ = 1.568±0.01 µM）表现出相对更好的电势。对比对接研究表明，化合物3f与曲酸相比，对蘑菇酪氨酸酶（PDBID：2Y9X）具有最大结合亲和力，结合能值为（-6.90 kcal / mol）。化合物3f中的4-甲氧基显示出与Cu的100％相互作用。化合物3f在1.71和1.74的距离处与His61和His94表现出氢键相互作用，这可能与曲酸相比具有更高的活性。