Oxidative stress and excessive lipid accumulation in liver tissues are considered as important factors in development of non-alcoholic fatty liver disease (NAFLD), which is the most common chronic liver disease worldwide and strongly associated with insulin resistance, obesity and dyslipidemia. In this study, the effect of PMFs-enriched extract of Daoxianyeju (Citrus daoxianensis S.W. He) (EDX) on NAFLD were examined using high fat diet-induced obesity (DIO) C57BL/6 mice. Daily supplementation of 0.2% and 0.5% EDX with high fat diet (w/w) over ten weeks markedly improved glucose tolerance and insulin resistance as well as lipid profiles, alleviated hepatic steatosis, inflammatory and oxidative stress. The benefit of EDX on improving pathology of NAFLD induced by high fat diet may associate with the activation of nuclear factor erythroid-2 related factor 2 (Nrf2) pathways in liver tissues. Our study showed that citrus PMFs may use as a dietary therapy for NAFLD and related metabolic disorders.

氧化应激和肝脏组织中过多的脂质蓄积被认为是非酒精性脂肪性肝病（NAFLD）发展的重要因素，非酒精性脂肪性肝病是全世界最常见的慢性肝病，与胰岛素抵抗，肥胖和血脂异常密切相关。在这项研究中，富含PMFs的刀仙叶菊（Citrus daoxianensis）提取物的作用使用高脂饮食诱导的肥胖症（DIO）C57BL / 6小鼠检查了NAFLD上的SW He）（EDX）。在十周内每天补充0.2％和0.5％EDX和高脂饮食（w / w）可以显着改善葡萄糖耐量和胰岛素抵抗以及血脂状况，减轻肝脂肪变性，炎症和氧化应激。EDX对改善高脂饮食引起的NAFLD病理学的益处可能与肝组织中核因子erythroid-2相关因子2（Nrf2）途径的激活有关。我们的研究表明，柑橘类PMF可用作NAFLD和相关代谢紊乱的饮食疗法。