Plasmonic metal nanoparticles have been explored as a new class of chemical read-outs for assaying of a variety of chemical and biological species because of their unique physico-chemical and size dependent properties. Metal nanoparticles-based optical technologies are based on either new class of organic molecular assembly or with aggregation-induced optical changes features, which can also improve the sensitivity of drug assays in pharmaceutical analysis. This review describes the advantages of surface chemistry of plasmonic metal nanoparticles (e.g., silver, copper, gold, and platinum) for tuning of their colorimetric sensing applications in various drugs assays in pharmaceutical and biological samples. It provides insights of various plasmonic metal nanoparticles-based sensing strategies for the selective, sensitive and simultaneous colorimetric assay of drugs in pharmaceutical samples. Finally, we listed some research challenges to accelerate the development of plasmonic metal nanoparticles-based colorimetric sensors that are directly applicable for assaying drugs in pharmaceutical samples.

等离子体金属纳米颗粒由于其独特的理化性质和尺寸依赖性，已被开发为一种用于分析多种化学和生物物种的新型化学读出物。基于金属纳米粒子的光学技术基于新型的有机分子组装或具有聚集诱导的光学变化特征，这也可以提高药物分析在药物分析中的敏感性。这篇综述描述了等离子体金属纳米颗粒（例如，银，铜，金和铂）的表面化学在调节比色传感在制药和生物样品的各种药物分析中的应用方面的优势。它提供了各种基于等离激元金属纳米颗粒的传感策略的见解，以进行选择性的，药物样品中药物的同时灵敏和比色测定。最后，我们列出了一些研究挑战，以加速基于等离激元金属纳米颗粒的比色传感器的开发，这些传感器可直接用于测定药物样品中的药物。