Abstract In the current study, the biocompatibility and mechanical characteristics of glass-infiltrated zirconia were improved via a simple composite coating made of Zn-doped hydroxyapatite (ZnHA) ceramic and a silicate-based glass. During thermal treatment, significant reaction and crystallisation occurred and some of the ZnHA was transformed into β-tricalcium phosphate, calcium oxide phosphate, and calcium zirconium oxide. Moreover, the glass crystallised into a sodium calcium aluminium silicate phase. The mechanical properties were investigated and the results indicated that the amount of glass in the composite and in the glass-infiltrated zirconia layer strongly affected the flexural strength and adhesion of the coating layer. The composite coatings on the glass-infiltrated zirconia displayed better mechanical properties than the pure ZnHA coating due to the newly formed crystalline phases. Murine pre-osteoblastic (MC3T3-E1) cells adhered to and spread well on the composite coating surfaces. The cell viability results revealed that the glass/ZnHA composites demonstrated a superior bioactivity of osteoblast cells compared to uncoated zirconia. These results show that the glass/ZnHA composites on the glass-infiltrated zirconia structure are suitable for use as hard tissue implant coatings due to their morphological and mechanical stability and enhanced bioactivity to pre-osteoblastic cells.

中文翻译：

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通过玻璃熔合在玻璃渗透氧化锆上的玻璃/锌-羟基磷灰石复合涂层中调整界面相互作用

摘要 在目前的研究中，通过由掺锌羟基磷灰石 (ZnHA) 陶瓷和硅酸盐玻璃制成的简单复合涂层，提高了玻璃渗透氧化锆的生物相容性和机械特性。在热处理过程中，发生了显着的反应和结晶，部分 ZnHA 转化为 β-磷酸三钙、磷酸氧化钙和氧化锆钙。此外，玻璃结晶成钠钙铝硅酸盐相。研究了机械性能，结果表明复合材料和玻璃渗透氧化锆层中玻璃的含量对涂层的弯曲强度和附着力有很大影响。由于新形成的结晶相，玻璃渗透氧化锆上的复合涂层显示出比纯 ZnHA 涂层更好的机械性能。鼠前成骨细胞 (MC3T3-E1) 细胞粘附在复合涂层表面并在其上很好地扩散。细胞活力结果表明，与未涂覆的氧化锆相比，玻璃/ZnHA 复合材料显示出优异的成骨细胞生物活性。这些结果表明，玻璃浸润氧化锆结构上的玻璃/ZnHA 复合材料由于其形态和机械稳定性以及对成骨前细胞的生物活性增强而适合用作硬组织植入物涂层。细胞活力结果表明，与未涂覆的氧化锆相比，玻璃/ZnHA 复合材料显示出优异的成骨细胞生物活性。这些结果表明，玻璃浸润氧化锆结构上的玻璃/ZnHA 复合材料由于其形态和机械稳定性以及对成骨前细胞的生物活性增强而适合用作硬组织植入物涂层。细胞活力结果表明，与未涂覆的氧化锆相比，玻璃/ZnHA 复合材料显示出优异的成骨细胞生物活性。这些结果表明，玻璃浸润氧化锆结构上的玻璃/ZnHA 复合材料由于其形态和机械稳定性以及对成骨前细胞的生物活性增强而适合用作硬组织植入物涂层。