Herein, the ternary composites, ultrasmall metal nanoparticles encapsulated in the anionic metal-organic frameworks/electrochemically reduced graphene oxide ([email protected], 4-NDC-MOF/ERGO, M = Ag, Cu) are constructed by a cationic exchange strategy and an electrochemical reduction process for the electrochemical determination of H₂O₂. Both [email protected], 4-NDC-MOF/ERGO and [email protected], 4-NDC-MOF/ERGO display excellent electrocatalytic activity toward H₂O₂, but the former is superior to the latter. Such a difference in electrocatalytic activity can be explained by the characterization measurements, and the results manifest [email protected], 4-NDC-MOF/ERGO (M = Ag, Cu) electrocatalysts have subequal MNPs sizes and electrochemical surface areas, but different electron transfer rate constants. The [email protected], 4-NDC-MOF/ERGO sensor shows a linear detection range from 4 to 11,000 μM with the detection limit of 0.18 μM. Moreover, [email protected], 4-NDC-MOF/ERGO (M = Ag, Cu) exhibit excellent anti-interference performance and can be used for the detection of H₂O₂ released from living cells. The proposed sensor takes full advantage of the catalytic property of MNPs, the size selectivity of Y-1, 4-NDC-MOF, and the fast electron transport effect of ERGO. Thus, the [email protected], 4-NDC-MOF/ERGO/GCE (M = Ag, Cu) can be utilized to detect oxidase activities by monitoring H₂O₂ produced in the presence of substrate and oxidase, and it is expected that composites with the molecular sieving effect and catalytic activity can be widely applied for catalysis, biomedicine, and biosensing fields.

在此，通过阳离子交换策略构建三元复合物，包裹在阴离子金属-有机骨架/电化学还原的氧化石墨烯（[受电子邮件保护]，4-NDC-MOF / ERGO，M = Ag，Cu）中的超小金属纳米颗粒，并用于电化学测定H ₂ O ₂的电化学还原过程。4-NDC-MOF / ERGO [受电子邮件保护]和4-NDC-MOF / ERGO [受电子邮件保护]对H ₂ O _2均具有出色的电催化活性，但前者要优于后者。这种电催化活性的差异可以通过表征测量来解释，结果表明，[N电子邮件保护] 4-NDC-MOF / ERGO（M = Ag，Cu）电催化剂的MNP尺寸和电化学表面积均相等，但电子不同传输速率常数。[电子邮件保护] 4-NDC-MOF / ERGO传感器的线性检测范围为4至11,000μM，检测极限为0.18μM。此外，[受电子邮件保护]，4-NDC-MOF / ERGO（M = Ag，Cu）具有出色的抗干扰性能，可用于检测H ₂ O ₂从活细胞中释放出来。所提出的传感器充分利用了MNPs的催化性能，Y-1的尺寸选择性，4-NDC-MOF以及ERGO的快速电子传输效应。因此，[受电子邮件保护的] 4-NDC-MOF / ERGO / GCE（M = Ag，Cu）可用于通过监测在底物和氧化酶存在下产生的H ₂ O ₂来检测氧化酶活性，并且有望具有分子筛作用和催化活性的复合材料可广泛应用于催化，生物医学和生物传感领域。