A mitochondria-targeting hetero-binuclear Ir(iii)–Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells†,Chemical Communications

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A mitochondria-targeting hetero-binuclear Ir(iii)–Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-05-25 00:00:00 , DOI: 10.1039/c8cc02795a
Cheng Ouyang _{1,

2,

3,

4,

5} , Lei Chen _{6,

7,

8,

9,

10} , Thomas W. Rees _{1,

2,

3,

4,

5} , Yu Chen _{1,

2,

3,

4,

5} , Jiankang Liu _{6,

7,

8,

9,

10} , Liangnian Ji _{1,

2,

3,

4,

5} , Jiangang Long _{6,

7,

8,

9,

10} , Hui Chao _{1,

2,

3,

4,

5}

Affiliation

A hetero-binuclear Ir(III)–Pt(II) complex was developed as an antitumor agent. In vitro cytotoxicity results indicated that this complex was effective against cisplatin-resistant tumor cells. Mechanism experiments showed that it can overcome cisplatin resistance by increasing cellular uptake, targeting mitochondria, and inducing cell necrosis.

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